Entry Inhibition of Influenza Viruses with High Mannose Binding Lectin ESA-2 from the Red Alga Eucheuma serra through the Recognition of Viral Hemagglutinin

Entry Inhibition of Influenza Viruses with High Mannose Binding Lectin ESA-2 from the Red Alga Eucheuma serra through the Recognition of Viral Hemagglutinin

Lectin sensitivity of the recent pandemic influenza A virus (H1N1-2009) was screened for 12 lectins with various carbohydrate specificity by a neutral red dye uptake assay with MDCK cells. Among them, a high mannose (HM)-binding anti-HIV lectin, ESA-2 from the red alga Eucheuma serra, showed the hig...

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Bibliographic Details
Main Authors: Yuichiro Sato, Kinjiro Morimoto, Takanori Kubo, Takemasa Sakaguchi, Akira Nishizono, Makoto Hirayama, Kanji Hori
Format: Article
Language:English
Published: MDPI AG 2015-05-01
Series:Marine Drugs
Subjects:
lectin
red algae
Eucheuma serra
high mannose glycan
anti-influenza activity
Online Access:http://www.mdpi.com/1660-3397/13/6/3454

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