Dark Sweet Cherry (<i>Prunus avium</i>) Anthocyanins Suppressed ERK1/2-Akt/mTOR Cell Signaling and Oxidative Stress: Implications for TNBC Growth and Invasion

Dark Sweet Cherry (<i>Prunus avium</i>) Anthocyanins Suppressed ERK1/2-Akt/mTOR Cell Signaling and Oxidative Stress: Implications for TNBC Growth and Invasion

This study aimed to assess dark sweet cherry (DSC) total polyphenols (WE) and anthocyanins (ACN) against metastatic breast cancer (BC). The WE and ACN anticancer activity and underlying mechanisms were assessed in vitro using 4T1 BC cells. A pilot study using a BALB/C mouse syngeneic model bearing 4...

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Bibliographic Details
Main Authors: Ana Carolina Silveira Rabelo, Susanne U. Mertens-Talcott, Boon P. Chew, Giuliana Noratto
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Molecules
Subjects:
4T1-CRL-2539
anthocyanins
dark sweet cherries
polyphenols
metastasis
angiogenesis
Online Access:https://www.mdpi.com/1420-3049/27/21/7245

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