Fas/FasL promoter gene polymorphism in patients with rheumatoid arthritis
<em>Objectives</em>. Fas/FasL is significantly involved in the pathogenesis of rheumatoid arthritis (RA). Fas/FasL gene polymorphism may be associated with susceptibility to rheumatoid arthritis and disease severity. <em>Aim</em>. To investigate the Fas 670 G/A and FasL 843 C...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2012-12-01
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| Series: | Reumatismo |
| Subjects: | |
| Online Access: | http://www.reumatismo.org/index.php/reuma/article/view/624 |
| _version_ | 1828489644896944128 |
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| author | A. Berdeli Ş. Kobak |
| author_facet | A. Berdeli Ş. Kobak |
| author_sort | A. Berdeli |
| collection | DOAJ |
| description | <em>Objectives</em>. Fas/FasL is significantly involved in the pathogenesis of rheumatoid arthritis (RA). Fas/FasL gene polymorphism may be associated with susceptibility to rheumatoid arthritis and disease severity. <em>Aim</em>. To investigate the Fas 670 G/A and FasL 843 C/T genotype and allele frequency in patients with RA, and determine its potential association with susceptibility to the disease and the clinical parameters. <em>Methods</em>. One hundred and one patients with RA and 105 healthy control subjects were enrolled in the study. Fas 670 A/G and FasL 843C/T genotype polymorphism was investigated by PCR-RFLP. Chi-square test was used for determining the genotype distribution and the allele incidence. <em>Results</em>. There was no statistically significant difference between the patients with RA and the healthy subjects with respect to Fas-670 A/G and FasL-843C/T genotype distribution and allele frequency (P>0.05). While there was no statistically significant difference in disease severity and various clinical parameters, a correlation was detected between Fas-670 polymorphism and anti-CCP antibody and anemia (P<0.01 and P<0.03, respectively). <em>Conclusions</em>. Fas-670A/G and FasL-843C/T promoter gene polymorphisms are not considered to represent a major genetic risk factor for RA susceptibility and disease severity. However, based on these results, Fas-670 promoter polymorphism may modulate anti-CCP antibody synthesis and response in patients with rheumatoid arthritis. |
| first_indexed | 2024-12-11T10:29:36Z |
| format | Article |
| id | doaj.art-acd5e5a40a1c4c9ab6ff0c0c07fdea93 |
| institution | Directory Open Access Journal |
| issn | 0048-7449 2240-2683 |
| language | English |
| last_indexed | 2024-12-11T10:29:36Z |
| publishDate | 2012-12-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Reumatismo |
| spelling | doaj.art-acd5e5a40a1c4c9ab6ff0c0c07fdea932022-12-22T01:11:00ZengPAGEPress PublicationsReumatismo0048-74492240-26832012-12-0164637437910.4081/reumatismo.2012.374Fas/FasL promoter gene polymorphism in patients with rheumatoid arthritisA. BerdeliŞ. Kobak<em>Objectives</em>. Fas/FasL is significantly involved in the pathogenesis of rheumatoid arthritis (RA). Fas/FasL gene polymorphism may be associated with susceptibility to rheumatoid arthritis and disease severity. <em>Aim</em>. To investigate the Fas 670 G/A and FasL 843 C/T genotype and allele frequency in patients with RA, and determine its potential association with susceptibility to the disease and the clinical parameters. <em>Methods</em>. One hundred and one patients with RA and 105 healthy control subjects were enrolled in the study. Fas 670 A/G and FasL 843C/T genotype polymorphism was investigated by PCR-RFLP. Chi-square test was used for determining the genotype distribution and the allele incidence. <em>Results</em>. There was no statistically significant difference between the patients with RA and the healthy subjects with respect to Fas-670 A/G and FasL-843C/T genotype distribution and allele frequency (P>0.05). While there was no statistically significant difference in disease severity and various clinical parameters, a correlation was detected between Fas-670 polymorphism and anti-CCP antibody and anemia (P<0.01 and P<0.03, respectively). <em>Conclusions</em>. Fas-670A/G and FasL-843C/T promoter gene polymorphisms are not considered to represent a major genetic risk factor for RA susceptibility and disease severity. However, based on these results, Fas-670 promoter polymorphism may modulate anti-CCP antibody synthesis and response in patients with rheumatoid arthritis.http://www.reumatismo.org/index.php/reuma/article/view/624rheumatoid arthritis, Fas/FasL, gene polymorphism, association, manifestations |
| spellingShingle | A. Berdeli Ş. Kobak Fas/FasL promoter gene polymorphism in patients with rheumatoid arthritis Reumatismo rheumatoid arthritis, Fas/FasL, gene polymorphism, association, manifestations |
| title | Fas/FasL promoter gene polymorphism in patients with rheumatoid arthritis |
| title_full | Fas/FasL promoter gene polymorphism in patients with rheumatoid arthritis |
| title_fullStr | Fas/FasL promoter gene polymorphism in patients with rheumatoid arthritis |
| title_full_unstemmed | Fas/FasL promoter gene polymorphism in patients with rheumatoid arthritis |
| title_short | Fas/FasL promoter gene polymorphism in patients with rheumatoid arthritis |
| title_sort | fas fasl promoter gene polymorphism in patients with rheumatoid arthritis |
| topic | rheumatoid arthritis, Fas/FasL, gene polymorphism, association, manifestations |
| url | http://www.reumatismo.org/index.php/reuma/article/view/624 |
| work_keys_str_mv | AT aberdeli fasfaslpromotergenepolymorphisminpatientswithrheumatoidarthritis AT skobak fasfaslpromotergenepolymorphisminpatientswithrheumatoidarthritis |