Implication of Vestibular Hair Cell Loss of Planar Polarity for the Canal and Otolith-Dependent Vestibulo-Ocular Reflexes in Celsr1–/– Mice

Implication of Vestibular Hair Cell Loss of Planar Polarity for the Canal and Otolith-Dependent Vestibulo-Ocular Reflexes in Celsr1–/– Mice

Introduction: Vestibular sensory hair cells are precisely orientated according to planar cell polarity (PCP) and are key to enable mechanic-electrical transduction and normal vestibular function. PCP is found on different scales in the vestibular organs, ranging from correct hair bundle orientation,...

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Bibliographic Details
Main Authors: François Simon, Fadel Tissir, Vincent Michel, Ghizlene Lahlou, Michael Deans, Mathieu Beraneck
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Neuroscience
Subjects:
vestibulo ocular reflex
planar cell polarity (PCP)
vestibular system
CELSR1
mouse model
hair cell
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.750596/full

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