Onychomycosis: Old and New
Onychomycosis is a common chronic fungal infection of the nail that causes discoloration and/or thickening of the nail plate. Oral agents are generally preferred, except in the case of mild toenail infection limited to the distal nail plate. Terbinafine and itraconazole are the only approved oral th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Journal of Fungi |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2309-608X/9/5/559 |
| _version_ | 1797599537433411584 |
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| author | Narges Maskan Bermudez Giselle Rodríguez-Tamez Sofia Perez Antonella Tosti |
| author_facet | Narges Maskan Bermudez Giselle Rodríguez-Tamez Sofia Perez Antonella Tosti |
| author_sort | Narges Maskan Bermudez |
| collection | DOAJ |
| description | Onychomycosis is a common chronic fungal infection of the nail that causes discoloration and/or thickening of the nail plate. Oral agents are generally preferred, except in the case of mild toenail infection limited to the distal nail plate. Terbinafine and itraconazole are the only approved oral therapies, and fluconazole is commonly utilized off-label. Cure rates with these therapies are limited, and resistance to terbinafine is starting to develop worldwide. In this review, we aim to review current oral treatment options for onychomycosis, as well as novel oral drugs that may have promising results in the treatment of onychomycosis. |
| first_indexed | 2024-03-11T03:35:45Z |
| format | Article |
| id | doaj.art-acd7d914c3cc4be1ac547cdb1f8bdba8 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-11T03:35:45Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-acd7d914c3cc4be1ac547cdb1f8bdba82023-11-18T02:02:18ZengMDPI AGJournal of Fungi2309-608X2023-05-019555910.3390/jof9050559Onychomycosis: Old and NewNarges Maskan Bermudez0Giselle Rodríguez-Tamez1Sofia Perez2Antonella Tosti3Dr. Philip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33125, USADermatology Department, University Hospital “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey 64460, MexicoDr. Philip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33125, USADr. Philip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33125, USAOnychomycosis is a common chronic fungal infection of the nail that causes discoloration and/or thickening of the nail plate. Oral agents are generally preferred, except in the case of mild toenail infection limited to the distal nail plate. Terbinafine and itraconazole are the only approved oral therapies, and fluconazole is commonly utilized off-label. Cure rates with these therapies are limited, and resistance to terbinafine is starting to develop worldwide. In this review, we aim to review current oral treatment options for onychomycosis, as well as novel oral drugs that may have promising results in the treatment of onychomycosis.https://www.mdpi.com/2309-608X/9/5/559onychomycosisdermatophytedermoscopyfungal culturefungal nail infectionnondermatophyte |
| spellingShingle | Narges Maskan Bermudez Giselle Rodríguez-Tamez Sofia Perez Antonella Tosti Onychomycosis: Old and New Journal of Fungi onychomycosis dermatophyte dermoscopy fungal culture fungal nail infection nondermatophyte |
| title | Onychomycosis: Old and New |
| title_full | Onychomycosis: Old and New |
| title_fullStr | Onychomycosis: Old and New |
| title_full_unstemmed | Onychomycosis: Old and New |
| title_short | Onychomycosis: Old and New |
| title_sort | onychomycosis old and new |
| topic | onychomycosis dermatophyte dermoscopy fungal culture fungal nail infection nondermatophyte |
| url | https://www.mdpi.com/2309-608X/9/5/559 |
| work_keys_str_mv | AT nargesmaskanbermudez onychomycosisoldandnew AT gisellerodrigueztamez onychomycosisoldandnew AT sofiaperez onychomycosisoldandnew AT antonellatosti onychomycosisoldandnew |