Rapid changes of mRNA expressions of cardiac ion channels affected by Torsadogenic drugs influence susceptibility of rat hearts to arrhythmias induced by Beta‐Adrenergic stimulation

Rapid changes of mRNA expressions of cardiac ion channels affected by Torsadogenic drugs influence susceptibility of rat hearts to arrhythmias induced by Beta‐Adrenergic stimulation

Abstract Drug‐induced long QT syndrome (LQTS) and Torsades de Pointes (TdP) are serious concerns in drug development. Although rats are a useful scientific tool, their hearts, unlike larger species, usually do not respond to torsadogenic drugs. Consequently, their resistance to drug‐induced arrhythm...

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Bibliographic Details
Main Authors: Katarina Hadova, Jana Kmecova, Katarina Ochodnicka‐Mackovicova, Eva Kralova, Gabriel Doka, Lenka Bies Pivackova, Peter Vavrinec, Tatiana Stankovicova, Peter Krenek, Jan Klimas
Format: Article
Language:English
Published: Wiley 2023-10-01
Series:Pharmacology Research & Perspectives
Subjects:
clarithromycin
furosemide
LQTS
Torsades de pointes
Online Access:https://doi.org/10.1002/prp2.1134

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