Complex Role of Microbiome in Pancreatic Tumorigenesis: Potential Therapeutic Implications
Pancreatic cancer (PC) is the fourth leading cause of cancer-related mortality with limited diagnostic and therapeutic options. Although immunotherapy has shown promise in the treatment of several cancers, its role in pancreatic cancer is rather limited. Several studies have focused on determining t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/12/1900 |
| _version_ | 1797489006568538112 |
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| author | Suneetha Amara Li V. Yang Venkataswarup Tiriveedhi Mahvish Muzaffar |
| author_facet | Suneetha Amara Li V. Yang Venkataswarup Tiriveedhi Mahvish Muzaffar |
| author_sort | Suneetha Amara |
| collection | DOAJ |
| description | Pancreatic cancer (PC) is the fourth leading cause of cancer-related mortality with limited diagnostic and therapeutic options. Although immunotherapy has shown promise in the treatment of several cancers, its role in pancreatic cancer is rather limited. Several studies have focused on determining the role of the tumor microenvironment with cancer-cell-intrinsic events and tumor-infiltrating immune cellular properties. However, in the past decade, there has been emerging research aimed at delineating the role of the host microbiome, including the metabolites from microbes and host responses, on pancreatic tumorigenesis. Importantly, there is emerging evidence suggesting the beneficial role of a gut microbiome transplant to improve immunotherapeutic outcomes in cancer patients. In this review, we summarize the recent understanding of the role of the microbiome in pancreatic cancer progression, along with its clinical diagnostic and therapeutic implications. |
| first_indexed | 2024-03-10T00:10:22Z |
| format | Article |
| id | doaj.art-acdbba9d04a048a2ae582a5edaec0398 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T00:10:22Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-acdbba9d04a048a2ae582a5edaec03982023-11-23T16:01:10ZengMDPI AGCells2073-44092022-06-011112190010.3390/cells11121900Complex Role of Microbiome in Pancreatic Tumorigenesis: Potential Therapeutic ImplicationsSuneetha Amara0Li V. Yang1Venkataswarup Tiriveedhi2Mahvish Muzaffar3Division of Hematology/Oncology, Department of Internal Medicine, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USADivision of Hematology/Oncology, Department of Internal Medicine, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USADepartment of Biological Sciences, Tennessee State University, Nashville, TN 37209, USADivision of Hematology/Oncology, Department of Internal Medicine, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USAPancreatic cancer (PC) is the fourth leading cause of cancer-related mortality with limited diagnostic and therapeutic options. Although immunotherapy has shown promise in the treatment of several cancers, its role in pancreatic cancer is rather limited. Several studies have focused on determining the role of the tumor microenvironment with cancer-cell-intrinsic events and tumor-infiltrating immune cellular properties. However, in the past decade, there has been emerging research aimed at delineating the role of the host microbiome, including the metabolites from microbes and host responses, on pancreatic tumorigenesis. Importantly, there is emerging evidence suggesting the beneficial role of a gut microbiome transplant to improve immunotherapeutic outcomes in cancer patients. In this review, we summarize the recent understanding of the role of the microbiome in pancreatic cancer progression, along with its clinical diagnostic and therapeutic implications.https://www.mdpi.com/2073-4409/11/12/1900pancreatic cancerimmunotherapymicrobiomemetabolitesinflammation |
| spellingShingle | Suneetha Amara Li V. Yang Venkataswarup Tiriveedhi Mahvish Muzaffar Complex Role of Microbiome in Pancreatic Tumorigenesis: Potential Therapeutic Implications Cells pancreatic cancer immunotherapy microbiome metabolites inflammation |
| title | Complex Role of Microbiome in Pancreatic Tumorigenesis: Potential Therapeutic Implications |
| title_full | Complex Role of Microbiome in Pancreatic Tumorigenesis: Potential Therapeutic Implications |
| title_fullStr | Complex Role of Microbiome in Pancreatic Tumorigenesis: Potential Therapeutic Implications |
| title_full_unstemmed | Complex Role of Microbiome in Pancreatic Tumorigenesis: Potential Therapeutic Implications |
| title_short | Complex Role of Microbiome in Pancreatic Tumorigenesis: Potential Therapeutic Implications |
| title_sort | complex role of microbiome in pancreatic tumorigenesis potential therapeutic implications |
| topic | pancreatic cancer immunotherapy microbiome metabolites inflammation |
| url | https://www.mdpi.com/2073-4409/11/12/1900 |
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