Silver/chiral pyrrolidinopyridine relay catalytic cycloisomerization/(2 + 3) cycloadditions of enynamides to asymmetrically synthesize bispirocyclopentenes as PDE1B inhibitors
Abstract Significant progress has been made in asymmetric synthesis through the use of transition metal catalysts combined with Lewis bases. However, the use of a dual catalytic system involving 4-aminopyridine and transition metal has received little attention. Here we show a metal/Lewis base relay...
Main Authors: | Jing Jiang, Jin Zhou, Yang Li, Cheng Peng, Gu He, Wei Huang, Gu Zhan, Bo Han |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-06-01
|
Series: | Communications Chemistry |
Online Access: | https://doi.org/10.1038/s42004-023-00921-6 |
Similar Items
-
Palladium- and ruthenium-catalyzed cycloisomerization of enynamides and enynhydrazides: a rapid approach to diverse azacyclic frameworks.
by: Walker, P, et al.
Published: (2013) -
Chiral boryl radical catalyzed asymmetric radical cycloisomerization
by: Jin, Jiamiao, et al.
Published: (2024) -
Gold and carbene relay catalytic enantioselective cycloisomerization/cyclization reactions of ynamides and enals
by: Zhou, Liejin, et al.
Published: (2020) -
Higher-Order Cycloisomerisations of Enynamides
by: Straker, R
Published: (2016) -
Development and mechanistic investigations into metal-catalysed cycloisomerisation of enynamides
by: Mekareeya, A
Published: (2017)