Le lymphangiome circonscrit superficiel de la langue
A 40-year-old HIV-positive female presented with an erythematous macular eruption involving the malar and periorbital area, the forehead and neck of six weeks of duration (A). She had initiated antiretroviral treatment with co-formulated tenofovir/lamivudine/efavirenz QD plus isoniazid preventive th...
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| Format: | Article |
| Language: | English |
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The Pan African Medical Journal
2018-04-01
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| Series: | The Pan African Medical Journal |
| Subjects: | |
| Online Access: |
https://www.panafrican-med-journal.com/content/article/29/202/pdf/202.pdf
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| _version_ | 1818489002547740672 |
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| author | Aicha Nassiri Fatima Zahra Mernissi |
| author_facet | Aicha Nassiri Fatima Zahra Mernissi |
| author_sort | Aicha Nassiri |
| collection | DOAJ |
| description | A 40-year-old HIV-positive female presented with an erythematous macular eruption involving the malar and periorbital area, the forehead and neck of six weeks of duration (A). She had initiated antiretroviral treatment with co-formulated tenofovir/lamivudine/efavirenz QD plus isoniazid preventive therapy (IPT) 18 weeks before with CD4 counts of 496 cells/l (25%). Drug-induced subacute cutaneous lupus erythematous (DI-SCLE) secondary to isoniazid was clinically diagnosed and isoniazid was stopped. Antinuclear antibody (ANA), anti-SSA/Ro, anti-SSB/La, anti-Sm, anti-RNP and antihistone antibodies were negative. Complete blood count, eGFR and liver transaminases were normal. Three months after stopping isoniazid, the skin lesions resolved completely, supporting the diagnosis of isoniazid-induced SCLE (B). DI-SCLE with negative ANA has been described, but there are no reports in HIV-infected patients. With the current expanded provision of IPT to people living with HIV, it is important to be aware of this rare side effect of isoniazid despite the negativity of antibody assays. |
| first_indexed | 2024-12-10T16:58:12Z |
| format | Article |
| id | doaj.art-acdc7d23584b476a8a6d464e2e0738d1 |
| institution | Directory Open Access Journal |
| issn | 1937-8688 1937-8688 |
| language | English |
| last_indexed | 2024-12-10T16:58:12Z |
| publishDate | 2018-04-01 |
| publisher | The Pan African Medical Journal |
| record_format | Article |
| series | The Pan African Medical Journal |
| spelling | doaj.art-acdc7d23584b476a8a6d464e2e0738d12022-12-22T01:40:39ZengThe Pan African Medical JournalThe Pan African Medical Journal1937-86881937-86882018-04-012920210.11604/pamj.2018.29.202.1505315053Le lymphangiome circonscrit superficiel de la langueAicha Nassiri0Fatima Zahra Mernissi1 Service de Dermatologie, CHU Hassan II, Fes, Maroc Service de Dermatologie, CHU Hassan II, Fes, Maroc A 40-year-old HIV-positive female presented with an erythematous macular eruption involving the malar and periorbital area, the forehead and neck of six weeks of duration (A). She had initiated antiretroviral treatment with co-formulated tenofovir/lamivudine/efavirenz QD plus isoniazid preventive therapy (IPT) 18 weeks before with CD4 counts of 496 cells/l (25%). Drug-induced subacute cutaneous lupus erythematous (DI-SCLE) secondary to isoniazid was clinically diagnosed and isoniazid was stopped. Antinuclear antibody (ANA), anti-SSA/Ro, anti-SSB/La, anti-Sm, anti-RNP and antihistone antibodies were negative. Complete blood count, eGFR and liver transaminases were normal. Three months after stopping isoniazid, the skin lesions resolved completely, supporting the diagnosis of isoniazid-induced SCLE (B). DI-SCLE with negative ANA has been described, but there are no reports in HIV-infected patients. With the current expanded provision of IPT to people living with HIV, it is important to be aware of this rare side effect of isoniazid despite the negativity of antibody assays. https://www.panafrican-med-journal.com/content/article/29/202/pdf/202.pdf tuberculosishivisoniazid preventive therapy |
| spellingShingle | Aicha Nassiri Fatima Zahra Mernissi Le lymphangiome circonscrit superficiel de la langue The Pan African Medical Journal tuberculosis hiv isoniazid preventive therapy |
| title | Le lymphangiome circonscrit superficiel de la langue |
| title_full | Le lymphangiome circonscrit superficiel de la langue |
| title_fullStr | Le lymphangiome circonscrit superficiel de la langue |
| title_full_unstemmed | Le lymphangiome circonscrit superficiel de la langue |
| title_short | Le lymphangiome circonscrit superficiel de la langue |
| title_sort | le lymphangiome circonscrit superficiel de la langue |
| topic | tuberculosis hiv isoniazid preventive therapy |
| url |
https://www.panafrican-med-journal.com/content/article/29/202/pdf/202.pdf
|
| work_keys_str_mv | AT aichanassiri lelymphangiomecirconscritsuperficieldelalangue AT fatimazahramernissi lelymphangiomecirconscritsuperficieldelalangue |