Long non-coding RNAs as a source of new peptides
Deep transcriptome sequencing has revealed the existence of many transcripts that lack long or conserved open reading frames (ORFs) and which have been termed long non-coding RNAs (lncRNAs). The vast majority of lncRNAs are lineage-specific and do not yet have a known function. In this study, we tes...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2014-09-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/03523 |
| _version_ | 1811201201521295360 |
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| author | Jorge Ruiz-Orera Xavier Messeguer Juan Antonio Subirana M Mar Alba |
| author_facet | Jorge Ruiz-Orera Xavier Messeguer Juan Antonio Subirana M Mar Alba |
| author_sort | Jorge Ruiz-Orera |
| collection | DOAJ |
| description | Deep transcriptome sequencing has revealed the existence of many transcripts that lack long or conserved open reading frames (ORFs) and which have been termed long non-coding RNAs (lncRNAs). The vast majority of lncRNAs are lineage-specific and do not yet have a known function. In this study, we test the hypothesis that they may act as a repository for the synthesis of new peptides. We find that a large fraction of the lncRNAs expressed in cells from six different species is associated with ribosomes. The patterns of ribosome protection are consistent with the translation of short peptides. lncRNAs show similar coding potential and sequence constraints than evolutionary young protein coding sequences, indicating that they play an important role in de novo protein evolution. |
| first_indexed | 2024-04-12T02:18:17Z |
| format | Article |
| id | doaj.art-acdeda95f94c47448ab186f9ab12129f |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:18:17Z |
| publishDate | 2014-09-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-acdeda95f94c47448ab186f9ab12129f2022-12-22T03:52:12ZengeLife Sciences Publications LtdeLife2050-084X2014-09-01310.7554/eLife.03523Long non-coding RNAs as a source of new peptidesJorge Ruiz-Orera0Xavier Messeguer1Juan Antonio Subirana2M Mar Alba3Evolutionary Genomics Group, Research Programme on Biomedical Informatics, Hospital del Mar Research Institute, Universitat Pompeu Fabra, Barcelona, SpainLlenguatges i Sistemes Informàtics, Universitat Politècnica de Catalunya, Barcelona, SpainEvolutionary Genomics Group, Research Programme on Biomedical Informatics, Hospital del Mar Research Institute, Universitat Pompeu Fabra, Barcelona, Spain; Real Academia de Ciències i Arts de Barcelona, Barcelona, SpainEvolutionary Genomics Group, Research Programme on Biomedical Informatics, Hospital del Mar Research Institute, Universitat Pompeu Fabra, Barcelona, Spain; Catalan Institution for Research and Advanced Studies, Barcelona, SpainDeep transcriptome sequencing has revealed the existence of many transcripts that lack long or conserved open reading frames (ORFs) and which have been termed long non-coding RNAs (lncRNAs). The vast majority of lncRNAs are lineage-specific and do not yet have a known function. In this study, we test the hypothesis that they may act as a repository for the synthesis of new peptides. We find that a large fraction of the lncRNAs expressed in cells from six different species is associated with ribosomes. The patterns of ribosome protection are consistent with the translation of short peptides. lncRNAs show similar coding potential and sequence constraints than evolutionary young protein coding sequences, indicating that they play an important role in de novo protein evolution.https://elifesciences.org/articles/03523lncRNAribosome profilingeukaryotede novo gene evolution |
| spellingShingle | Jorge Ruiz-Orera Xavier Messeguer Juan Antonio Subirana M Mar Alba Long non-coding RNAs as a source of new peptides eLife lncRNA ribosome profiling eukaryote de novo gene evolution |
| title | Long non-coding RNAs as a source of new peptides |
| title_full | Long non-coding RNAs as a source of new peptides |
| title_fullStr | Long non-coding RNAs as a source of new peptides |
| title_full_unstemmed | Long non-coding RNAs as a source of new peptides |
| title_short | Long non-coding RNAs as a source of new peptides |
| title_sort | long non coding rnas as a source of new peptides |
| topic | lncRNA ribosome profiling eukaryote de novo gene evolution |
| url | https://elifesciences.org/articles/03523 |
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