Partially hydrolyzed guar gum increased colonic mucus layer in mice via succinate-mediated MUC2 production

Partially hydrolyzed guar gum increased colonic mucus layer in mice via succinate-mediated MUC2 production

Abstract Colonic mucus layers protect intestinal tissues against intestinal bacteria. We investigated the effects of dietary fiber and its metabolites on mucus production in the colonic mucosa. Mice were fed a partially hydrolyzed guar gum (PHGG)-containing diet and a fiber-free diet (FFD). The colo...

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Bibliographic Details
Main Authors: Mariko Kajiwara-Kubota, Kazuhiko Uchiyama, Kohei Asaeda, Reo Kobayashi, Hikaru Hashimoto, Takeshi Yasuda, Satoshi Sugino, Takeshi Sugaya, Yasuko Hirai, Katsura Mizushima, Toshifumi Doi, Ken Inoue, Osamu Dohi, Naohisa Yoshida, Takeshi Ishikawa, Tomohisa Takagi, Hideyuki Konishi, Ryo Inoue, Yoshito Itoh, Yuji Naito
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:npj Science of Food
Online Access:https://doi.org/10.1038/s41538-023-00184-4

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