Dynamic transcriptome landscape in the song nucleus HVC between juvenile and adult zebra finches
Abstract Male juvenile zebra finches learn to sing by imitating songs of adult males early in life. The development of the song control circuit and song learning and maturation are highly intertwined processes, involving gene expression, neurogenesis, circuit formation, synaptic modification, and se...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-03-01
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| Series: | Advanced Genetics |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ggn2.10035 |
| _version_ | 1811340037940314112 |
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| author | Zhimin Shi Zeyu Zhang Lana Schaffer Zhi Huang Lijuan Fu Steven Head Terry Gaasterland Xiu‐Jie Wang XiaoChing Li |
| author_facet | Zhimin Shi Zeyu Zhang Lana Schaffer Zhi Huang Lijuan Fu Steven Head Terry Gaasterland Xiu‐Jie Wang XiaoChing Li |
| author_sort | Zhimin Shi |
| collection | DOAJ |
| description | Abstract Male juvenile zebra finches learn to sing by imitating songs of adult males early in life. The development of the song control circuit and song learning and maturation are highly intertwined processes, involving gene expression, neurogenesis, circuit formation, synaptic modification, and sensory‐motor learning. To better understand the genetic and genomic mechanisms underlying these events, we used RNA‐Seq to examine genome‐wide transcriptomes in the song control nucleus HVC of male juvenile (45 d) and adult (100 d) zebra finches. We report that gene groups related to axon guidance, RNA processing, lipid metabolism, and mitochondrial functions show enriched expression in juvenile HVC compared to the rest of the brain. As juveniles mature into adulthood, massive gene expression changes occur. Expression of genes related to amino acid metabolism, cell cycle, and mitochondrial function is reduced, accompanied by increased and enriched expression of genes with synaptic functions, including genes related to G‐protein signaling, neurotransmitter receptors, transport of small molecules, and potassium channels. Unexpectedly, a group of genes with immune system functions is also developmentally regulated, suggesting potential roles in the development and functions of HVC. These data will serve as a rich resource for investigations into the development and function of a neural circuit that controls vocal behavior. |
| first_indexed | 2024-04-13T18:35:26Z |
| format | Article |
| id | doaj.art-ace08d74b5d64b67b75cf90000ef42d6 |
| institution | Directory Open Access Journal |
| issn | 2641-6573 |
| language | English |
| last_indexed | 2024-04-13T18:35:26Z |
| publishDate | 2021-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Genetics |
| spelling | doaj.art-ace08d74b5d64b67b75cf90000ef42d62022-12-22T02:34:54ZengWileyAdvanced Genetics2641-65732021-03-0121n/an/a10.1002/ggn2.10035Dynamic transcriptome landscape in the song nucleus HVC between juvenile and adult zebra finchesZhimin Shi0Zeyu Zhang1Lana Schaffer2Zhi Huang3Lijuan Fu4Steven Head5Terry Gaasterland6Xiu‐Jie Wang7XiaoChing Li8Neuroscience Center of Excellence Louisiana State University School of Medicine New Orleans Louisiana USAKey Laboratory of Genetic Network Biology Institute of Genetics and Developmental Biology, Chinese Academy of Sciences Beijing ChinaScripps Research Institute La Jolla California USANeuroscience Center of Excellence Louisiana State University School of Medicine New Orleans Louisiana USANeuroscience Center of Excellence Louisiana State University School of Medicine New Orleans Louisiana USAScripps Research Institute La Jolla California USAScripps Research Institute La Jolla California USAKey Laboratory of Genetic Network Biology Institute of Genetics and Developmental Biology, Chinese Academy of Sciences Beijing ChinaNeuroscience Center of Excellence Louisiana State University School of Medicine New Orleans Louisiana USAAbstract Male juvenile zebra finches learn to sing by imitating songs of adult males early in life. The development of the song control circuit and song learning and maturation are highly intertwined processes, involving gene expression, neurogenesis, circuit formation, synaptic modification, and sensory‐motor learning. To better understand the genetic and genomic mechanisms underlying these events, we used RNA‐Seq to examine genome‐wide transcriptomes in the song control nucleus HVC of male juvenile (45 d) and adult (100 d) zebra finches. We report that gene groups related to axon guidance, RNA processing, lipid metabolism, and mitochondrial functions show enriched expression in juvenile HVC compared to the rest of the brain. As juveniles mature into adulthood, massive gene expression changes occur. Expression of genes related to amino acid metabolism, cell cycle, and mitochondrial function is reduced, accompanied by increased and enriched expression of genes with synaptic functions, including genes related to G‐protein signaling, neurotransmitter receptors, transport of small molecules, and potassium channels. Unexpectedly, a group of genes with immune system functions is also developmentally regulated, suggesting potential roles in the development and functions of HVC. These data will serve as a rich resource for investigations into the development and function of a neural circuit that controls vocal behavior.https://doi.org/10.1002/ggn2.10035circuit developmentgene expressionHVCRNA‐Seqvocal communicationzebra finch |
| spellingShingle | Zhimin Shi Zeyu Zhang Lana Schaffer Zhi Huang Lijuan Fu Steven Head Terry Gaasterland Xiu‐Jie Wang XiaoChing Li Dynamic transcriptome landscape in the song nucleus HVC between juvenile and adult zebra finches Advanced Genetics circuit development gene expression HVC RNA‐Seq vocal communication zebra finch |
| title | Dynamic transcriptome landscape in the song nucleus HVC between juvenile and adult zebra finches |
| title_full | Dynamic transcriptome landscape in the song nucleus HVC between juvenile and adult zebra finches |
| title_fullStr | Dynamic transcriptome landscape in the song nucleus HVC between juvenile and adult zebra finches |
| title_full_unstemmed | Dynamic transcriptome landscape in the song nucleus HVC between juvenile and adult zebra finches |
| title_short | Dynamic transcriptome landscape in the song nucleus HVC between juvenile and adult zebra finches |
| title_sort | dynamic transcriptome landscape in the song nucleus hvc between juvenile and adult zebra finches |
| topic | circuit development gene expression HVC RNA‐Seq vocal communication zebra finch |
| url | https://doi.org/10.1002/ggn2.10035 |
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