The Effect of Thyroid Stimulating Hormone Level Within the Reference Range on In-Hospital and Short-Term Prognosis in Acute Coronary Syndrome Patients
<i>Background and objectives:</i> Despite being within the normal reference range, changes in thyroid stimulating hormone (TSH) levels have negative effects on the cardiovascular system. The majority of patients admitted to hospital with acute coronary syndrome (ACS) are euthyroid. The a...
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| Format: | Article |
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MDPI AG
2019-05-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1010-660X/55/5/175 |
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| author | Muhammet Gürdoğan Servet Altay Selçuk Korkmaz Çağlar Kaya Utku Zeybey Mustafa Ebik Melik Demir |
| author_facet | Muhammet Gürdoğan Servet Altay Selçuk Korkmaz Çağlar Kaya Utku Zeybey Mustafa Ebik Melik Demir |
| author_sort | Muhammet Gürdoğan |
| collection | DOAJ |
| description | <i>Background and objectives:</i> Despite being within the normal reference range, changes in thyroid stimulating hormone (TSH) levels have negative effects on the cardiovascular system. The majority of patients admitted to hospital with acute coronary syndrome (ACS) are euthyroid. The aim of this study was to investigate the effect of TSH level on the prognosis of in-hospital and follow-up periods of euthyroid ACS patients. <i>Materials and Methods:</i> A total of 629 patients with acute coronary syndrome without thyroid dysfunction were included in the study. TSH levels of patients were 0.3–5.33 uIU/mL. Patients were divided into three TSH tertiles: TSH level between (1) 0.3 uIU/mL and <0.90 uIU/mL (<i>n</i> = 209), (2) 0.90 uIU/mL and <1.60 uIU/mL (<i>n</i> = 210), and (3) 1.60 uIU/mL and 5.33 uIU/mL (<i>n</i> = 210). Demographic, clinical laboratory, and angiographic characteristics were compared between groups in terms of in-hospital and follow-up prognosis. <i>Results:</i> Mean age was 63.42 ± 12.5, and 73.9% were male. There was significant difference between tertiles in terms of TSH level at admission (<i>p</i> < 0.001), the severity of coronary artery disease (<i>p</i> = 0.024), in-hospital mortality (<i>p</i> < 0.001), in-hospital major hemorrhage (<i>p</i> = 0.005), total adverse clinical event (<i>p</i> = 0.03), follow-up mortality (<i>p</i> = 0.022), and total mortality (<i>p</i> < 0.001). In multivariate logistic regression analysis, the high–normal TSH tertile was found to be cumulative mortality increasing factor (OR = 6.307, 95%; CI: 1.769–22.480; <i>p</i> = 0.005) during the 6-month follow-up period after hospitalization and discharge. <i>Conclusions:</i> High–normal TSH tertile during hospital admission in euthyroid ACS patients is an independent predictor of total mortality during the 6-month follow-up period after hospitalization and discharge. |
| first_indexed | 2024-03-12T11:07:46Z |
| format | Article |
| id | doaj.art-ace224552ddc40f3b268361a4b203453 |
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| language | English |
| last_indexed | 2024-03-12T11:07:46Z |
| publishDate | 2019-05-01 |
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| spelling | doaj.art-ace224552ddc40f3b268361a4b2034532023-09-02T03:31:06ZengMDPI AGMedicina1010-660X2019-05-0155517510.3390/medicina55050175medicina55050175The Effect of Thyroid Stimulating Hormone Level Within the Reference Range on In-Hospital and Short-Term Prognosis in Acute Coronary Syndrome PatientsMuhammet Gürdoğan0Servet Altay1Selçuk Korkmaz2Çağlar Kaya3Utku Zeybey4Mustafa Ebik5Melik Demir6Department of Cardiology, School of Medicine, Trakya University, 22030 Edirne, TurkeyDepartment of Cardiology, School of Medicine, Trakya University, 22030 Edirne, TurkeyDepartment of Biostatistics and Medical Informatics, School of Medicine, Trakya University, 22030 Edirne, TurkeyDepartment of Cardiology, School of Medicine, Trakya University, 22030 Edirne, TurkeyDepartment of Cardiology, School of Medicine, Trakya University, 22030 Edirne, TurkeyDepartment of Cardiology, School of Medicine, Trakya University, 22030 Edirne, TurkeyDepartment of Cardiology, School of Medicine, Trakya University, 22030 Edirne, Turkey<i>Background and objectives:</i> Despite being within the normal reference range, changes in thyroid stimulating hormone (TSH) levels have negative effects on the cardiovascular system. The majority of patients admitted to hospital with acute coronary syndrome (ACS) are euthyroid. The aim of this study was to investigate the effect of TSH level on the prognosis of in-hospital and follow-up periods of euthyroid ACS patients. <i>Materials and Methods:</i> A total of 629 patients with acute coronary syndrome without thyroid dysfunction were included in the study. TSH levels of patients were 0.3–5.33 uIU/mL. Patients were divided into three TSH tertiles: TSH level between (1) 0.3 uIU/mL and <0.90 uIU/mL (<i>n</i> = 209), (2) 0.90 uIU/mL and <1.60 uIU/mL (<i>n</i> = 210), and (3) 1.60 uIU/mL and 5.33 uIU/mL (<i>n</i> = 210). Demographic, clinical laboratory, and angiographic characteristics were compared between groups in terms of in-hospital and follow-up prognosis. <i>Results:</i> Mean age was 63.42 ± 12.5, and 73.9% were male. There was significant difference between tertiles in terms of TSH level at admission (<i>p</i> < 0.001), the severity of coronary artery disease (<i>p</i> = 0.024), in-hospital mortality (<i>p</i> < 0.001), in-hospital major hemorrhage (<i>p</i> = 0.005), total adverse clinical event (<i>p</i> = 0.03), follow-up mortality (<i>p</i> = 0.022), and total mortality (<i>p</i> < 0.001). In multivariate logistic regression analysis, the high–normal TSH tertile was found to be cumulative mortality increasing factor (OR = 6.307, 95%; CI: 1.769–22.480; <i>p</i> = 0.005) during the 6-month follow-up period after hospitalization and discharge. <i>Conclusions:</i> High–normal TSH tertile during hospital admission in euthyroid ACS patients is an independent predictor of total mortality during the 6-month follow-up period after hospitalization and discharge.https://www.mdpi.com/1010-660X/55/5/175acute coronary syndromethyroid-stimulating hormonemortalityprognosis |
| spellingShingle | Muhammet Gürdoğan Servet Altay Selçuk Korkmaz Çağlar Kaya Utku Zeybey Mustafa Ebik Melik Demir The Effect of Thyroid Stimulating Hormone Level Within the Reference Range on In-Hospital and Short-Term Prognosis in Acute Coronary Syndrome Patients Medicina acute coronary syndrome thyroid-stimulating hormone mortality prognosis |
| title | The Effect of Thyroid Stimulating Hormone Level Within the Reference Range on In-Hospital and Short-Term Prognosis in Acute Coronary Syndrome Patients |
| title_full | The Effect of Thyroid Stimulating Hormone Level Within the Reference Range on In-Hospital and Short-Term Prognosis in Acute Coronary Syndrome Patients |
| title_fullStr | The Effect of Thyroid Stimulating Hormone Level Within the Reference Range on In-Hospital and Short-Term Prognosis in Acute Coronary Syndrome Patients |
| title_full_unstemmed | The Effect of Thyroid Stimulating Hormone Level Within the Reference Range on In-Hospital and Short-Term Prognosis in Acute Coronary Syndrome Patients |
| title_short | The Effect of Thyroid Stimulating Hormone Level Within the Reference Range on In-Hospital and Short-Term Prognosis in Acute Coronary Syndrome Patients |
| title_sort | effect of thyroid stimulating hormone level within the reference range on in hospital and short term prognosis in acute coronary syndrome patients |
| topic | acute coronary syndrome thyroid-stimulating hormone mortality prognosis |
| url | https://www.mdpi.com/1010-660X/55/5/175 |
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