Neurological manifestations and neuroimaging findings in patients with SARS-CoV2—a systematic review
Abstract Background The COVID-19 pandemic has drastically affected everyone in a hit or miss manner. Since it began, evidence of the neuro-invasive potential of the virus has been intensifying significantly. Several pathways have been hypothesized to elucidate the neurotropic nature of SARS-CoV2. It...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-06-01
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| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41983-021-00322-3 |
| _version_ | 1818864951593271296 |
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| author | Nikita Mohan Muhammad Ali Fayyaz Christopher del Rio Navpreet Kaur Rajinder Singh Khurana Sampada Sandip Vaidya Esteban Salazar John Joyce Amrat Ayaz Ali |
| author_facet | Nikita Mohan Muhammad Ali Fayyaz Christopher del Rio Navpreet Kaur Rajinder Singh Khurana Sampada Sandip Vaidya Esteban Salazar John Joyce Amrat Ayaz Ali |
| author_sort | Nikita Mohan |
| collection | DOAJ |
| description | Abstract Background The COVID-19 pandemic has drastically affected everyone in a hit or miss manner. Since it began, evidence of the neuro-invasive potential of the virus has been intensifying significantly. Several pathways have been hypothesized to elucidate the neurotropic nature of SARS-CoV2. It is the need of the hour to collect vital information. Objective To evaluate and correlate the neuro-radiological and neurological manifestations in patients diagnosed with SARS-CoV2. To identify neuro-invasive pathways of COVID infection. Methods Relevant studies were identified through four databases—the Cochrane Library, PubMed, Science Direct, and Web of Science. These were searched using relevant keywords—“COVID-19,” “SARS-CoV2,” “neurological manifestations,” “neuroimaging,” “CT,” and “MRI.” Relevant articles were screened according to a pre-defined inclusion and exclusion criteria from December 2019 to August 2020. Results Our review included a total of 63 full text publications with 584 patients, composed mainly of observational studies, case reports, and case series. The most common neurological manifestations associated with COVID-19 were altered mental status, stroke, and paralysis. About 17.85% patients who underwent neuroimaging were found to be having ischemic changes suggestive of a stroke. This was followed by hemorrhagic changes as the second most common finding. The most commonly involved vessel was the Middle Cerebral Artery. Besides stroke, we found that SARS-CoV2 could be the cause for new-onset seizures, Guillain-Barre Syndrome, encephalitis, and many other severe neurological diseases. Conclusion The information that we have obtained so far will prove dynamic to healthcare providers working against the COVID-19 pandemic. It is necessary to be aware of these atypical neurological findings for the early diagnosis and treatment of COVID-19 infected patients. However, to completely understand the connection between SARS-CoV2 and the nervous system, further research is necessary. |
| first_indexed | 2024-12-19T10:39:49Z |
| format | Article |
| id | doaj.art-ace51d256c114d92a070d328a33026f5 |
| institution | Directory Open Access Journal |
| issn | 1687-8329 |
| language | English |
| last_indexed | 2024-12-19T10:39:49Z |
| publishDate | 2021-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj.art-ace51d256c114d92a070d328a33026f52022-12-21T20:25:29ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292021-06-0157111910.1186/s41983-021-00322-3Neurological manifestations and neuroimaging findings in patients with SARS-CoV2—a systematic reviewNikita Mohan0Muhammad Ali Fayyaz1Christopher del Rio2Navpreet Kaur Rajinder Singh Khurana3Sampada Sandip Vaidya4Esteban Salazar5John Joyce6Amrat Ayaz Ali7Jawaharlal Nehru Medical CollegeQuaid e Azam Medical CollegeTecnologico de Monterrey, Escuela de Medicina y Ciencias de la SaludIndira Gandhi Government Medical College & Mayo HospitalKazan State Medical UniversityTecnologico de Monterrey, Escuela de Medicina y Ciencias de la SaludM.S Ramaiah Medical CollegeLiaquat University of Medical and Health SciencesAbstract Background The COVID-19 pandemic has drastically affected everyone in a hit or miss manner. Since it began, evidence of the neuro-invasive potential of the virus has been intensifying significantly. Several pathways have been hypothesized to elucidate the neurotropic nature of SARS-CoV2. It is the need of the hour to collect vital information. Objective To evaluate and correlate the neuro-radiological and neurological manifestations in patients diagnosed with SARS-CoV2. To identify neuro-invasive pathways of COVID infection. Methods Relevant studies were identified through four databases—the Cochrane Library, PubMed, Science Direct, and Web of Science. These were searched using relevant keywords—“COVID-19,” “SARS-CoV2,” “neurological manifestations,” “neuroimaging,” “CT,” and “MRI.” Relevant articles were screened according to a pre-defined inclusion and exclusion criteria from December 2019 to August 2020. Results Our review included a total of 63 full text publications with 584 patients, composed mainly of observational studies, case reports, and case series. The most common neurological manifestations associated with COVID-19 were altered mental status, stroke, and paralysis. About 17.85% patients who underwent neuroimaging were found to be having ischemic changes suggestive of a stroke. This was followed by hemorrhagic changes as the second most common finding. The most commonly involved vessel was the Middle Cerebral Artery. Besides stroke, we found that SARS-CoV2 could be the cause for new-onset seizures, Guillain-Barre Syndrome, encephalitis, and many other severe neurological diseases. Conclusion The information that we have obtained so far will prove dynamic to healthcare providers working against the COVID-19 pandemic. It is necessary to be aware of these atypical neurological findings for the early diagnosis and treatment of COVID-19 infected patients. However, to completely understand the connection between SARS-CoV2 and the nervous system, further research is necessary.https://doi.org/10.1186/s41983-021-00322-3SARS-CoV 2StrokeNeuro-invasiveCOVID-19Neuroimaging |
| spellingShingle | Nikita Mohan Muhammad Ali Fayyaz Christopher del Rio Navpreet Kaur Rajinder Singh Khurana Sampada Sandip Vaidya Esteban Salazar John Joyce Amrat Ayaz Ali Neurological manifestations and neuroimaging findings in patients with SARS-CoV2—a systematic review The Egyptian Journal of Neurology, Psychiatry and Neurosurgery SARS-CoV 2 Stroke Neuro-invasive COVID-19 Neuroimaging |
| title | Neurological manifestations and neuroimaging findings in patients with SARS-CoV2—a systematic review |
| title_full | Neurological manifestations and neuroimaging findings in patients with SARS-CoV2—a systematic review |
| title_fullStr | Neurological manifestations and neuroimaging findings in patients with SARS-CoV2—a systematic review |
| title_full_unstemmed | Neurological manifestations and neuroimaging findings in patients with SARS-CoV2—a systematic review |
| title_short | Neurological manifestations and neuroimaging findings in patients with SARS-CoV2—a systematic review |
| title_sort | neurological manifestations and neuroimaging findings in patients with sars cov2 a systematic review |
| topic | SARS-CoV 2 Stroke Neuro-invasive COVID-19 Neuroimaging |
| url | https://doi.org/10.1186/s41983-021-00322-3 |
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