A multi-enzyme cascade for efficient production of d-p-hydroxyphenylglycine from l-tyrosine

A multi-enzyme cascade for efficient production of d-p-hydroxyphenylglycine from l-tyrosine

Abstract In this study, a four-enzyme cascade pathway was developed and reconstructed in vivo for the production of d-p-hydroxyphenylglycine (D-HPG), a valuable intermediate used to produce β-lactam antibiotics and in fine-chemical synthesis, from l-tyrosine. In this pathway, catalytic conversion of...

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Bibliographic Details
Main Authors: Xu Tan, Sheng Zhang, Wei Song, Jia Liu, Cong Gao, Xiulai Chen, Liming Liu, Jing Wu
Format: Article
Language:English
Published: SpringerOpen 2021-05-01
Series:Bioresources and Bioprocessing
Subjects:
d-p-hydroxyphenylglycine
meso-diaminopimelate dehydrogenase
Hydride transfer distance
l-tyrosine
Protein engineering
Online Access:https://doi.org/10.1186/s40643-021-00394-2

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