XPC–PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair
Cells employ global genome nucleotide excision repair to repair a broad spectrum of genomic DNA lesions. Here, the authors reveal how chromatin is primed for repair, providing insight into mechanisms of chromatin plasticity during DNA repair.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-31820-4 |
| _version_ | 1811215854233190400 |
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| author | Charlotte Blessing Katja Apelt Diana van den Heuvel Claudia Gonzalez-Leal Magdalena B. Rother Melanie van der Woude Román González-Prieto Adi Yifrach Avital Parnas Rashmi G. Shah Tia Tyrsett Kuo Daphne E. C. Boer Jin Cai Angela Kragten Hyun-Suk Kim Orlando D. Schärer Alfred C. O. Vertegaal Girish M. Shah Sheera Adar Hannes Lans Haico van Attikum Andreas G. Ladurner Martijn S. Luijsterburg |
| author_facet | Charlotte Blessing Katja Apelt Diana van den Heuvel Claudia Gonzalez-Leal Magdalena B. Rother Melanie van der Woude Román González-Prieto Adi Yifrach Avital Parnas Rashmi G. Shah Tia Tyrsett Kuo Daphne E. C. Boer Jin Cai Angela Kragten Hyun-Suk Kim Orlando D. Schärer Alfred C. O. Vertegaal Girish M. Shah Sheera Adar Hannes Lans Haico van Attikum Andreas G. Ladurner Martijn S. Luijsterburg |
| author_sort | Charlotte Blessing |
| collection | DOAJ |
| description | Cells employ global genome nucleotide excision repair to repair a broad spectrum of genomic DNA lesions. Here, the authors reveal how chromatin is primed for repair, providing insight into mechanisms of chromatin plasticity during DNA repair. |
| first_indexed | 2024-04-12T06:30:28Z |
| format | Article |
| id | doaj.art-ace7be3e1e274f3a94341103b43f7ce6 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T06:30:28Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ace7be3e1e274f3a94341103b43f7ce62022-12-22T03:44:02ZengNature PortfolioNature Communications2041-17232022-08-0113111810.1038/s41467-022-31820-4XPC–PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repairCharlotte Blessing0Katja Apelt1Diana van den Heuvel2Claudia Gonzalez-Leal3Magdalena B. Rother4Melanie van der Woude5Román González-Prieto6Adi Yifrach7Avital Parnas8Rashmi G. Shah9Tia Tyrsett Kuo10Daphne E. C. Boer11Jin Cai12Angela Kragten13Hyun-Suk Kim14Orlando D. Schärer15Alfred C. O. Vertegaal16Girish M. Shah17Sheera Adar18Hannes Lans19Haico van Attikum20Andreas G. Ladurner21Martijn S. Luijsterburg22Biomedical Center (BMC), Physiological Chemistry, Faculty of Medicine, LMU MunichDepartment of Human Genetics, Leiden University Medical Center (LUMC)Department of Human Genetics, Leiden University Medical Center (LUMC)Biomedical Center (BMC), Physiological Chemistry, Faculty of Medicine, LMU MunichDepartment of Human Genetics, Leiden University Medical Center (LUMC)Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical CenterDepartment of Cell and Chemical Biology, Leiden University Medical Center (LUMC)Department of Microbiology and Molecular Genetics, The Institute for Medical Research Israel-Canada, The Faculty of Medicine, The Hebrew University of JerusalemDepartment of Microbiology and Molecular Genetics, The Institute for Medical Research Israel-Canada, The Faculty of Medicine, The Hebrew University of JerusalemLaboratory for Skin Cancer Research, CHU-Q: Laval University Hospital Research Centre of Quebec (CHUL site)Biomedical Center (BMC), Physiological Chemistry, Faculty of Medicine, LMU MunichDepartment of Human Genetics, Leiden University Medical Center (LUMC)Biomedical Center (BMC), Physiological Chemistry, Faculty of Medicine, LMU MunichDepartment of Human Genetics, Leiden University Medical Center (LUMC)Center for Genomic Integrity, Institute for Basic ScienceCenter for Genomic Integrity, Institute for Basic ScienceDepartment of Cell and Chemical Biology, Leiden University Medical Center (LUMC)Laboratory for Skin Cancer Research, CHU-Q: Laval University Hospital Research Centre of Quebec (CHUL site)Department of Microbiology and Molecular Genetics, The Institute for Medical Research Israel-Canada, The Faculty of Medicine, The Hebrew University of JerusalemDepartment of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical CenterDepartment of Human Genetics, Leiden University Medical Center (LUMC)Biomedical Center (BMC), Physiological Chemistry, Faculty of Medicine, LMU MunichDepartment of Human Genetics, Leiden University Medical Center (LUMC)Cells employ global genome nucleotide excision repair to repair a broad spectrum of genomic DNA lesions. Here, the authors reveal how chromatin is primed for repair, providing insight into mechanisms of chromatin plasticity during DNA repair.https://doi.org/10.1038/s41467-022-31820-4 |
| spellingShingle | Charlotte Blessing Katja Apelt Diana van den Heuvel Claudia Gonzalez-Leal Magdalena B. Rother Melanie van der Woude Román González-Prieto Adi Yifrach Avital Parnas Rashmi G. Shah Tia Tyrsett Kuo Daphne E. C. Boer Jin Cai Angela Kragten Hyun-Suk Kim Orlando D. Schärer Alfred C. O. Vertegaal Girish M. Shah Sheera Adar Hannes Lans Haico van Attikum Andreas G. Ladurner Martijn S. Luijsterburg XPC–PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair Nature Communications |
| title | XPC–PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair |
| title_full | XPC–PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair |
| title_fullStr | XPC–PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair |
| title_full_unstemmed | XPC–PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair |
| title_short | XPC–PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair |
| title_sort | xpc parp complexes engage the chromatin remodeler alc1 to catalyze global genome dna damage repair |
| url | https://doi.org/10.1038/s41467-022-31820-4 |
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