Preparation and characterization of multifunctional magnetic mesoporous calcium silicate materials
We have prepared multifunctional magnetic mesoporous Fe–CaSiO3 materials using triblock copolymer (P123) as a structure-directing agent. The effects of Fe substitution on the mesoporous structure, in vitro bioactivity, magnetic heating ability and drug delivery property of mesoporous CaSiO3 material...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2013-01-01
|
| Series: | Science and Technology of Advanced Materials |
| Online Access: | http://dx.doi.org/10.1088/1468-6996/14/5/055009 |
| _version_ | 1811281370536738816 |
|---|---|
| author | Jianhua Zhang, Yufang Zhu, Jie Li, Min Zhu, Cuilian Tao and Nobutaka Hanagata |
| author_facet | Jianhua Zhang, Yufang Zhu, Jie Li, Min Zhu, Cuilian Tao and Nobutaka Hanagata |
| author_sort | Jianhua Zhang, Yufang Zhu, Jie Li, Min Zhu, Cuilian Tao and Nobutaka Hanagata |
| collection | DOAJ |
| description | We have prepared multifunctional magnetic mesoporous Fe–CaSiO3 materials using triblock copolymer (P123) as a structure-directing agent. The effects of Fe substitution on the mesoporous structure, in vitro bioactivity, magnetic heating ability and drug delivery property of mesoporous CaSiO3 materials were investigated. Mesoporous Fe–CaSiO3 materials had similar mesoporous channels (5–6 nm) with different Fe substitution. When 5 and 10% Fe were substituted for Ca in mesoporous CaSiO3 materials, mesoporous Fe–CaSiO3 materials still showed good apatite-formation ability and had no cytotoxic effect on osteoblast-like MC3T3-E1 cells evaluated by the elution cell culture assay. On the other hand, mesoporous Fe–CaSiO3 materials could generate heat to raise the temperature of the surrounding environment in an alternating magnetic field due to their superparamagnetic property. When we use gentamicin (GS) as a model drug, mesoporous Fe–CaSiO3 materials release GS in a sustained manner. Therefore, magnetic mesoporous Fe–CaSiO3 materials would be a promising multifunctional platform with bone regeneration, local drug delivery and magnetic hyperthermia. |
| first_indexed | 2024-04-13T01:31:14Z |
| format | Article |
| id | doaj.art-ace94ffecb544fe2af23420b6d72f3cb |
| institution | Directory Open Access Journal |
| issn | 1468-6996 1878-5514 |
| language | English |
| last_indexed | 2024-04-13T01:31:14Z |
| publishDate | 2013-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Science and Technology of Advanced Materials |
| spelling | doaj.art-ace94ffecb544fe2af23420b6d72f3cb2022-12-22T03:08:30ZengTaylor & Francis GroupScience and Technology of Advanced Materials1468-69961878-55142013-01-0114505500910.1088/1468-6996/14/5/055009Preparation and characterization of multifunctional magnetic mesoporous calcium silicate materialsJianhua Zhang, Yufang Zhu, Jie Li, Min Zhu, Cuilian Tao and Nobutaka HanagataWe have prepared multifunctional magnetic mesoporous Fe–CaSiO3 materials using triblock copolymer (P123) as a structure-directing agent. The effects of Fe substitution on the mesoporous structure, in vitro bioactivity, magnetic heating ability and drug delivery property of mesoporous CaSiO3 materials were investigated. Mesoporous Fe–CaSiO3 materials had similar mesoporous channels (5–6 nm) with different Fe substitution. When 5 and 10% Fe were substituted for Ca in mesoporous CaSiO3 materials, mesoporous Fe–CaSiO3 materials still showed good apatite-formation ability and had no cytotoxic effect on osteoblast-like MC3T3-E1 cells evaluated by the elution cell culture assay. On the other hand, mesoporous Fe–CaSiO3 materials could generate heat to raise the temperature of the surrounding environment in an alternating magnetic field due to their superparamagnetic property. When we use gentamicin (GS) as a model drug, mesoporous Fe–CaSiO3 materials release GS in a sustained manner. Therefore, magnetic mesoporous Fe–CaSiO3 materials would be a promising multifunctional platform with bone regeneration, local drug delivery and magnetic hyperthermia.http://dx.doi.org/10.1088/1468-6996/14/5/055009 |
| spellingShingle | Jianhua Zhang, Yufang Zhu, Jie Li, Min Zhu, Cuilian Tao and Nobutaka Hanagata Preparation and characterization of multifunctional magnetic mesoporous calcium silicate materials Science and Technology of Advanced Materials |
| title | Preparation and characterization of multifunctional magnetic mesoporous calcium silicate materials |
| title_full | Preparation and characterization of multifunctional magnetic mesoporous calcium silicate materials |
| title_fullStr | Preparation and characterization of multifunctional magnetic mesoporous calcium silicate materials |
| title_full_unstemmed | Preparation and characterization of multifunctional magnetic mesoporous calcium silicate materials |
| title_short | Preparation and characterization of multifunctional magnetic mesoporous calcium silicate materials |
| title_sort | preparation and characterization of multifunctional magnetic mesoporous calcium silicate materials |
| url | http://dx.doi.org/10.1088/1468-6996/14/5/055009 |
| work_keys_str_mv | AT jianhuazhangyufangzhujieliminzhucuiliantaoandnobutakahanagata preparationandcharacterizationofmultifunctionalmagneticmesoporouscalciumsilicatematerials |