ImmunoPET Directed to the Brain: A New Tool for Preclinical and Clinical Neuroscience
Immuno-positron emission tomography (immunoPET) is a non-invasive in vivo imaging method based on tracking and quantifying radiolabeled monoclonal antibodies (mAbs) and other related molecules, such as antibody fragments, nanobodies, or affibodies. However, the success of immunoPET in neuroimaging i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/1/164 |
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| author | Ángel García de Lucas Urpo Lamminmäki Francisco R. López-Picón |
| author_facet | Ángel García de Lucas Urpo Lamminmäki Francisco R. López-Picón |
| author_sort | Ángel García de Lucas |
| collection | DOAJ |
| description | Immuno-positron emission tomography (immunoPET) is a non-invasive in vivo imaging method based on tracking and quantifying radiolabeled monoclonal antibodies (mAbs) and other related molecules, such as antibody fragments, nanobodies, or affibodies. However, the success of immunoPET in neuroimaging is limited because intact antibodies cannot penetrate the blood–brain barrier (BBB). In neuro-oncology, immunoPET has been successfully applied to brain tumors because of the compromised BBB. Different strategies, such as changes in antibody properties, use of physiological mechanisms in the BBB, or induced changes to BBB permeability, have been developed to deliver antibodies to the brain. These approaches have recently started to be applied in preclinical central nervous system PET studies. Therefore, immunoPET could be a new approach for developing more specific PET probes directed to different brain targets. |
| first_indexed | 2024-03-09T13:26:32Z |
| format | Article |
| id | doaj.art-ace97b2095bc43f4a3770f07ebb258dd |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T13:26:32Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-ace97b2095bc43f4a3770f07ebb258dd2023-11-30T21:23:40ZengMDPI AGBiomolecules2218-273X2023-01-0113116410.3390/biom13010164ImmunoPET Directed to the Brain: A New Tool for Preclinical and Clinical NeuroscienceÁngel García de Lucas0Urpo Lamminmäki1Francisco R. López-Picón2PET Preclinical Imaging Laboratory, Turku PET Centre, University of Turku, 20520 Turku, FinlandDepartment of Life Technologies, University of Turku, 20520 Turku, FinlandPET Preclinical Imaging Laboratory, Turku PET Centre, University of Turku, 20520 Turku, FinlandImmuno-positron emission tomography (immunoPET) is a non-invasive in vivo imaging method based on tracking and quantifying radiolabeled monoclonal antibodies (mAbs) and other related molecules, such as antibody fragments, nanobodies, or affibodies. However, the success of immunoPET in neuroimaging is limited because intact antibodies cannot penetrate the blood–brain barrier (BBB). In neuro-oncology, immunoPET has been successfully applied to brain tumors because of the compromised BBB. Different strategies, such as changes in antibody properties, use of physiological mechanisms in the BBB, or induced changes to BBB permeability, have been developed to deliver antibodies to the brain. These approaches have recently started to be applied in preclinical central nervous system PET studies. Therefore, immunoPET could be a new approach for developing more specific PET probes directed to different brain targets.https://www.mdpi.com/2218-273X/13/1/164positron emission tomographyneuroimagingimmunoPETbrainblood–brain barrierantibody engineering |
| spellingShingle | Ángel García de Lucas Urpo Lamminmäki Francisco R. López-Picón ImmunoPET Directed to the Brain: A New Tool for Preclinical and Clinical Neuroscience Biomolecules positron emission tomography neuroimaging immunoPET brain blood–brain barrier antibody engineering |
| title | ImmunoPET Directed to the Brain: A New Tool for Preclinical and Clinical Neuroscience |
| title_full | ImmunoPET Directed to the Brain: A New Tool for Preclinical and Clinical Neuroscience |
| title_fullStr | ImmunoPET Directed to the Brain: A New Tool for Preclinical and Clinical Neuroscience |
| title_full_unstemmed | ImmunoPET Directed to the Brain: A New Tool for Preclinical and Clinical Neuroscience |
| title_short | ImmunoPET Directed to the Brain: A New Tool for Preclinical and Clinical Neuroscience |
| title_sort | immunopet directed to the brain a new tool for preclinical and clinical neuroscience |
| topic | positron emission tomography neuroimaging immunoPET brain blood–brain barrier antibody engineering |
| url | https://www.mdpi.com/2218-273X/13/1/164 |
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