Increased risk of hospitalization and death in Mexican children and adolescents with COVID-19 and comorbidities
Background: Although COVID-19 (coronavirus disease 2019) in children is usually mild, they need hospitalization and intensive care in exceptional cases. Adverse outcomes have been observed mainly among children with comorbidities, justifying their vaccination. This study aimed to assess the risk of...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Permanyer
2023-04-01
|
| Series: | Boletín Médico del Hospital Infantil de México |
| Subjects: | |
| Online Access: | https://www.bmhim.com/frame_esp.php?id=361 |
| _version_ | 1797831347477151744 |
|---|---|
| author | Pablo Méndez-Hernández Diego R. Hernández-Galdamez Miguel A. González-Block Daniela K. Romo-Dueñas Rosa M. Cahuantzi-Tamayo Omar Texis-Morales Juan J. Medina-Urzúa Rosalba Cerón-Meza Irma A. Hernández-Vicente Marivel Lumbreras-Guzmán |
| author_facet | Pablo Méndez-Hernández Diego R. Hernández-Galdamez Miguel A. González-Block Daniela K. Romo-Dueñas Rosa M. Cahuantzi-Tamayo Omar Texis-Morales Juan J. Medina-Urzúa Rosalba Cerón-Meza Irma A. Hernández-Vicente Marivel Lumbreras-Guzmán |
| author_sort | Pablo Méndez-Hernández |
| collection | DOAJ |
| description | Background: Although COVID-19 (coronavirus disease 2019) in children is usually mild, they need hospitalization and intensive care in exceptional cases. Adverse outcomes have been observed mainly among children with comorbidities, justifying their vaccination. This study aimed to assess the risk of hospitalization and death in Mexican children and adolescents with COVID-19 and comorbidities. Methods: A cross-sectional study was performed on 366,542 confirmed COVID-19 cases under 18 years, reported by the Mexican Ministry of Health up to July 9, 2022. Logistic regression models were performed. Results: The mean age was 10.98 years, 50.6% were male, and 7.3% reported at least one comorbidity. The percentage of hospitalization and death in COVID-19 patients with and without comorbidities was 3.52%, and 0.20%, respectively; children with comorbidities presented a higher percentage of hospitalization (14.0%) and death (1.9%). The probability of hospitalization was 5.6 times greater in pediatric patients with COVID-19 and comorbidities, and the comorbidities that showed the greatest risk were immunosuppression (odds ratio (OR) 22.06), chronic kidney disease (CKD) (11.36), and cardiovascular diseases (5.66). The probability of death in patients with comorbidities was 11.01 times higher than in those without diseases, and the highest risk was observed in those with CKD (OR 12.57), cardiovascular diseases (6.87), and diabetes (5.83). Conclusions: Pediatric patients with comorbidities presented a higher risk of severe COVID-19. It is suggested that vaccination should be promoted with greater emphasis on pediatric patients with comorbidities.
|
| first_indexed | 2024-04-09T13:50:32Z |
| format | Article |
| id | doaj.art-acea9bb75a914a5ea28bbc28f9d6eb74 |
| institution | Directory Open Access Journal |
| issn | 0539-6115 |
| language | English |
| last_indexed | 2024-04-09T13:50:32Z |
| publishDate | 2023-04-01 |
| publisher | Permanyer |
| record_format | Article |
| series | Boletín Médico del Hospital Infantil de México |
| spelling | doaj.art-acea9bb75a914a5ea28bbc28f9d6eb742023-05-08T18:21:00ZengPermanyerBoletín Médico del Hospital Infantil de México0539-61152023-04-0180210.24875/BMHIM.22000124Increased risk of hospitalization and death in Mexican children and adolescents with COVID-19 and comorbiditiesPablo Méndez-Hernández0Diego R. Hernández-Galdamez1Miguel A. González-Block2Daniela K. Romo-Dueñas3Rosa M. Cahuantzi-Tamayo4Omar Texis-Morales5Juan J. Medina-Urzúa6Rosalba Cerón-Meza7Irma A. Hernández-Vicente8Marivel Lumbreras-Guzmán9Facultad de Ciencias de la Salud, Universidad Autónoma de Tlaxcala, Tlaxcala, Mexico; Departamento de Calidad y Educación en Salud Secretaría de Salud de Tlaxcala, Tlaxcala, MexicoINCAP Research Center for the Prevention of Chronic Diseases, Instituto de Nutrición de Centro América y Panamá, Guatemala City, GuatemalaUniversidad Anáhuac, Mexico City, Mexico; Instituto Nacional de Salud Pública, Cuernavaca, Morelos, Mexico; Evisys Consulting, Mexico City, MexicoUniversidad del Valle de Guatemala, Centro de Estudios en Salud, Guatemala City, GuatemalaDepartamento de Calidad y Educación en Salud Secretaría de Salud de Tlaxcala, Tlaxcala, MexicoDepartamento de Calidad y Educación en Salud Secretaría de Salud de Tlaxcala, Tlaxcala, MexicoInstituto Nacional de Salud Pública, Cuernavaca, Morelos, MexicoFacultad de Agrobiología, Universidad Autónoma de Tlaxcala, Tlaxcala, MexicoINCAP Research Center for the Prevention of Chronic Diseases, Instituto de Nutrición de Centro América y Panamá, Guatemala City, Guatemala;, Hospital General de Huamantla, Secretaría de Salud de Tlaxcala, Tlaxcala, MexicoINCAP Research Center for the Prevention of Chronic Diseases, Instituto de Nutrición de Centro América y Panamá, Guatemala City, Guatemala;, Centro de Salud Urbano de Villa Vicente Guerrero Secretaría de Salud de Tlaxcala, Tlaxcala, MexicoBackground: Although COVID-19 (coronavirus disease 2019) in children is usually mild, they need hospitalization and intensive care in exceptional cases. Adverse outcomes have been observed mainly among children with comorbidities, justifying their vaccination. This study aimed to assess the risk of hospitalization and death in Mexican children and adolescents with COVID-19 and comorbidities. Methods: A cross-sectional study was performed on 366,542 confirmed COVID-19 cases under 18 years, reported by the Mexican Ministry of Health up to July 9, 2022. Logistic regression models were performed. Results: The mean age was 10.98 years, 50.6% were male, and 7.3% reported at least one comorbidity. The percentage of hospitalization and death in COVID-19 patients with and without comorbidities was 3.52%, and 0.20%, respectively; children with comorbidities presented a higher percentage of hospitalization (14.0%) and death (1.9%). The probability of hospitalization was 5.6 times greater in pediatric patients with COVID-19 and comorbidities, and the comorbidities that showed the greatest risk were immunosuppression (odds ratio (OR) 22.06), chronic kidney disease (CKD) (11.36), and cardiovascular diseases (5.66). The probability of death in patients with comorbidities was 11.01 times higher than in those without diseases, and the highest risk was observed in those with CKD (OR 12.57), cardiovascular diseases (6.87), and diabetes (5.83). Conclusions: Pediatric patients with comorbidities presented a higher risk of severe COVID-19. It is suggested that vaccination should be promoted with greater emphasis on pediatric patients with comorbidities. https://www.bmhim.com/frame_esp.php?id=361COVID-19. SARS-CoV-2. Comorbidities. Pediatrics. Hospitalization. Death. |
| spellingShingle | Pablo Méndez-Hernández Diego R. Hernández-Galdamez Miguel A. González-Block Daniela K. Romo-Dueñas Rosa M. Cahuantzi-Tamayo Omar Texis-Morales Juan J. Medina-Urzúa Rosalba Cerón-Meza Irma A. Hernández-Vicente Marivel Lumbreras-Guzmán Increased risk of hospitalization and death in Mexican children and adolescents with COVID-19 and comorbidities Boletín Médico del Hospital Infantil de México COVID-19. SARS-CoV-2. Comorbidities. Pediatrics. Hospitalization. Death. |
| title | Increased risk of hospitalization and death in Mexican children and adolescents with COVID-19 and comorbidities |
| title_full | Increased risk of hospitalization and death in Mexican children and adolescents with COVID-19 and comorbidities |
| title_fullStr | Increased risk of hospitalization and death in Mexican children and adolescents with COVID-19 and comorbidities |
| title_full_unstemmed | Increased risk of hospitalization and death in Mexican children and adolescents with COVID-19 and comorbidities |
| title_short | Increased risk of hospitalization and death in Mexican children and adolescents with COVID-19 and comorbidities |
| title_sort | increased risk of hospitalization and death in mexican children and adolescents with covid 19 and comorbidities |
| topic | COVID-19. SARS-CoV-2. Comorbidities. Pediatrics. Hospitalization. Death. |
| url | https://www.bmhim.com/frame_esp.php?id=361 |
| work_keys_str_mv | AT pablomendezhernandez increasedriskofhospitalizationanddeathinmexicanchildrenandadolescentswithcovid19andcomorbidities AT diegorhernandezgaldamez increasedriskofhospitalizationanddeathinmexicanchildrenandadolescentswithcovid19andcomorbidities AT miguelagonzalezblock increasedriskofhospitalizationanddeathinmexicanchildrenandadolescentswithcovid19andcomorbidities AT danielakromoduenas increasedriskofhospitalizationanddeathinmexicanchildrenandadolescentswithcovid19andcomorbidities AT rosamcahuantzitamayo increasedriskofhospitalizationanddeathinmexicanchildrenandadolescentswithcovid19andcomorbidities AT omartexismorales increasedriskofhospitalizationanddeathinmexicanchildrenandadolescentswithcovid19andcomorbidities AT juanjmedinaurzua increasedriskofhospitalizationanddeathinmexicanchildrenandadolescentswithcovid19andcomorbidities AT rosalbaceronmeza increasedriskofhospitalizationanddeathinmexicanchildrenandadolescentswithcovid19andcomorbidities AT irmaahernandezvicente increasedriskofhospitalizationanddeathinmexicanchildrenandadolescentswithcovid19andcomorbidities AT marivellumbrerasguzman increasedriskofhospitalizationanddeathinmexicanchildrenandadolescentswithcovid19andcomorbidities |