Prognosis of patients with laryngeal contact granuloma: Development and validation of RCGSG score
Abstract Objective This study aimed to develop an objective and simple score for predicting the prognosis of patients with laryngeal contact granuloma (LCG) treated with local glucocorticoid injection combined with oral proton pump inhibitor (GI + PPI). Methods Cox regression analysis was used to an...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-12-01
|
| Series: | Laryngoscope Investigative Otolaryngology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/lio2.969 |
| _version_ | 1811196214712991744 |
|---|---|
| author | Yufei Pan Jinrang Li Xiaoyu Wang Jinhong Zhang Chun Zhang Zhi Liu |
| author_facet | Yufei Pan Jinrang Li Xiaoyu Wang Jinhong Zhang Chun Zhang Zhi Liu |
| author_sort | Yufei Pan |
| collection | DOAJ |
| description | Abstract Objective This study aimed to develop an objective and simple score for predicting the prognosis of patients with laryngeal contact granuloma (LCG) treated with local glucocorticoid injection combined with oral proton pump inhibitor (GI + PPI). Methods Cox regression analysis was used to analyze the effect of baseline variables on the prognosis of 507 patients with LCG treated with GI + PPI. An easy‐to‐apply RCGSG (Reflus, Cough, Gender, and Surgery in GI + PPI therapy) score was developed based on the independent risk factors selected by univariate and multivariate Cox regression analyses. The score was internally validated by receiver‐operating characteristic curve, calibration curve, and decision curve analysis. Results After univariate and multivariate analyses, male gender (hazard ratio [HR] 0.546, p < .001), laryngopharyngeal reflux (HR 0.702, p = .001), chronic cough (HR 0.709, p = .001), and history of surgical resection (HR 0.433, p < .001) were found to be the independent risk factors affecting the prognosis of LCG. According to the score, the median cure time was 3 months (95% confidence interval [CI] 2.81–3.19) in the low‐risk group, 4 months (95% CI 3.74–4.26) in the moderate‐risk group, and 5 months (95% CI 4.76–5.24) in the high‐risk group. The bootstrap method was used to plot calibration curves for internal validation. Conclusion The RCGSG score, developed based on laryngopharyngeal reflux, chronic cough, gender, and surgical resection history, has been internally verified to be a good predictor of the prognosis of patients with LCG receiving GI + PPI treatment. Level of evidence Level 4. |
| first_indexed | 2024-04-12T00:54:59Z |
| format | Article |
| id | doaj.art-aceaf6db3c61406f95a321bac653df66 |
| institution | Directory Open Access Journal |
| issn | 2378-8038 |
| language | English |
| last_indexed | 2024-04-12T00:54:59Z |
| publishDate | 2022-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Laryngoscope Investigative Otolaryngology |
| spelling | doaj.art-aceaf6db3c61406f95a321bac653df662022-12-22T03:54:38ZengWileyLaryngoscope Investigative Otolaryngology2378-80382022-12-01761973197810.1002/lio2.969Prognosis of patients with laryngeal contact granuloma: Development and validation of RCGSG scoreYufei Pan0Jinrang Li1Xiaoyu Wang2Jinhong Zhang3Chun Zhang4Zhi Liu5Department of Otolaryngology – Head and Neck Surgery The Sixth Medical Center of PLA General Hospital of Beijing Beijing ChinaDepartment of Otolaryngology – Head and Neck Surgery The Sixth Medical Center of PLA General Hospital of Beijing Beijing ChinaDepartment of Otolaryngology – Head and Neck Surgery The Sixth Medical Center of PLA General Hospital of Beijing Beijing ChinaDepartment of Otolaryngology – Head and Neck Surgery The Sixth Medical Center of PLA General Hospital of Beijing Beijing ChinaDepartment of Otolaryngology – Head and Neck Surgery The Sixth Medical Center of PLA General Hospital of Beijing Beijing ChinaDepartment of Otolaryngology – Head and Neck Surgery The Sixth Medical Center of PLA General Hospital of Beijing Beijing ChinaAbstract Objective This study aimed to develop an objective and simple score for predicting the prognosis of patients with laryngeal contact granuloma (LCG) treated with local glucocorticoid injection combined with oral proton pump inhibitor (GI + PPI). Methods Cox regression analysis was used to analyze the effect of baseline variables on the prognosis of 507 patients with LCG treated with GI + PPI. An easy‐to‐apply RCGSG (Reflus, Cough, Gender, and Surgery in GI + PPI therapy) score was developed based on the independent risk factors selected by univariate and multivariate Cox regression analyses. The score was internally validated by receiver‐operating characteristic curve, calibration curve, and decision curve analysis. Results After univariate and multivariate analyses, male gender (hazard ratio [HR] 0.546, p < .001), laryngopharyngeal reflux (HR 0.702, p = .001), chronic cough (HR 0.709, p = .001), and history of surgical resection (HR 0.433, p < .001) were found to be the independent risk factors affecting the prognosis of LCG. According to the score, the median cure time was 3 months (95% confidence interval [CI] 2.81–3.19) in the low‐risk group, 4 months (95% CI 3.74–4.26) in the moderate‐risk group, and 5 months (95% CI 4.76–5.24) in the high‐risk group. The bootstrap method was used to plot calibration curves for internal validation. Conclusion The RCGSG score, developed based on laryngopharyngeal reflux, chronic cough, gender, and surgical resection history, has been internally verified to be a good predictor of the prognosis of patients with LCG receiving GI + PPI treatment. Level of evidence Level 4.https://doi.org/10.1002/lio2.969laryngeal contact granulomalocal glucocorticoid injectionmodelprognosis |
| spellingShingle | Yufei Pan Jinrang Li Xiaoyu Wang Jinhong Zhang Chun Zhang Zhi Liu Prognosis of patients with laryngeal contact granuloma: Development and validation of RCGSG score Laryngoscope Investigative Otolaryngology laryngeal contact granuloma local glucocorticoid injection model prognosis |
| title | Prognosis of patients with laryngeal contact granuloma: Development and validation of RCGSG score |
| title_full | Prognosis of patients with laryngeal contact granuloma: Development and validation of RCGSG score |
| title_fullStr | Prognosis of patients with laryngeal contact granuloma: Development and validation of RCGSG score |
| title_full_unstemmed | Prognosis of patients with laryngeal contact granuloma: Development and validation of RCGSG score |
| title_short | Prognosis of patients with laryngeal contact granuloma: Development and validation of RCGSG score |
| title_sort | prognosis of patients with laryngeal contact granuloma development and validation of rcgsg score |
| topic | laryngeal contact granuloma local glucocorticoid injection model prognosis |
| url | https://doi.org/10.1002/lio2.969 |
| work_keys_str_mv | AT yufeipan prognosisofpatientswithlaryngealcontactgranulomadevelopmentandvalidationofrcgsgscore AT jinrangli prognosisofpatientswithlaryngealcontactgranulomadevelopmentandvalidationofrcgsgscore AT xiaoyuwang prognosisofpatientswithlaryngealcontactgranulomadevelopmentandvalidationofrcgsgscore AT jinhongzhang prognosisofpatientswithlaryngealcontactgranulomadevelopmentandvalidationofrcgsgscore AT chunzhang prognosisofpatientswithlaryngealcontactgranulomadevelopmentandvalidationofrcgsgscore AT zhiliu prognosisofpatientswithlaryngealcontactgranulomadevelopmentandvalidationofrcgsgscore |