An In Vitro Study on the Efficacy of Mycotoxin Sequestering Agents for Aflatoxin B1, Deoxynivalenol, and Zearalenone
The objective of this study was to determine the efficacy of mycotoxin sequestering agents for aflatoxin B1 (AFB1), deoxynivalenol (DON), and zearalenone (ZEA) using an in vitro method. The twelve toxin sequestering agents tested were seven bentonite products (bentonite A, B, C, D, E, F, and G), two...
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MDPI AG
2022-01-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/12/3/333 |
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| author | Jong Young Ahn Jongkeon Kim Da Hyeon Cheong Hyosun Hong Jin Young Jeong Beob Gyun Kim |
| author_facet | Jong Young Ahn Jongkeon Kim Da Hyeon Cheong Hyosun Hong Jin Young Jeong Beob Gyun Kim |
| author_sort | Jong Young Ahn |
| collection | DOAJ |
| description | The objective of this study was to determine the efficacy of mycotoxin sequestering agents for aflatoxin B1 (AFB1), deoxynivalenol (DON), and zearalenone (ZEA) using an in vitro method. The twelve toxin sequestering agents tested were seven bentonite products (bentonite A, B, C, D, E, F, and G), two aluminosilicate products (aluminosilicate A and B), a heulandite product, an activated charcoal product, and a yeast cell wall product. A two-step in vitro procedure was employed to mimic the conditions of temperature, pH, and digestive enzymes in the stomach and small intestine of pigs. All mycotoxin sequestering agents tested were able to bind to AFB1 with a high efficacy (>92%). The DON sequestering rate of activated charcoal (99.1%) was greater (<i>p</i> < 0.05) than that of other products. The ZEA sequestering rate of bentonite F (97.0%), aluminosilicate A (99.6%), and activated charcoal (100.0%) was the greatest (<i>p</i> < 0.05) among the tested mycotoxin sequestering agents. Overall, most mycotoxin sequestering agents had the ability to bind to AFB1, but most products, except activated charcoal, failed to sequester DON and ZEA. |
| first_indexed | 2024-03-10T00:18:11Z |
| format | Article |
| id | doaj.art-aceafb209e3f4c64a21397e4482df3bc |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T00:18:11Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-aceafb209e3f4c64a21397e4482df3bc2023-11-23T15:48:08ZengMDPI AGAnimals2076-26152022-01-0112333310.3390/ani12030333An In Vitro Study on the Efficacy of Mycotoxin Sequestering Agents for Aflatoxin B1, Deoxynivalenol, and ZearalenoneJong Young Ahn0Jongkeon Kim1Da Hyeon Cheong2Hyosun Hong3Jin Young Jeong4Beob Gyun Kim5Department of Animal Science and Technology, Konkuk University, Seoul 05029, KoreaDepartment of Animal Science and Technology, Konkuk University, Seoul 05029, KoreaDepartment of Animal Science and Technology, Konkuk University, Seoul 05029, KoreaDepartment of Animal Science and Technology, Konkuk University, Seoul 05029, KoreaAnimal Nutritional Physiology Team, National Institute of Animal Science, Rural Development Administration, Wanju 55365, KoreaDepartment of Animal Science and Technology, Konkuk University, Seoul 05029, KoreaThe objective of this study was to determine the efficacy of mycotoxin sequestering agents for aflatoxin B1 (AFB1), deoxynivalenol (DON), and zearalenone (ZEA) using an in vitro method. The twelve toxin sequestering agents tested were seven bentonite products (bentonite A, B, C, D, E, F, and G), two aluminosilicate products (aluminosilicate A and B), a heulandite product, an activated charcoal product, and a yeast cell wall product. A two-step in vitro procedure was employed to mimic the conditions of temperature, pH, and digestive enzymes in the stomach and small intestine of pigs. All mycotoxin sequestering agents tested were able to bind to AFB1 with a high efficacy (>92%). The DON sequestering rate of activated charcoal (99.1%) was greater (<i>p</i> < 0.05) than that of other products. The ZEA sequestering rate of bentonite F (97.0%), aluminosilicate A (99.6%), and activated charcoal (100.0%) was the greatest (<i>p</i> < 0.05) among the tested mycotoxin sequestering agents. Overall, most mycotoxin sequestering agents had the ability to bind to AFB1, but most products, except activated charcoal, failed to sequester DON and ZEA.https://www.mdpi.com/2076-2615/12/3/333aflatoxin B1deoxynivalenolmycotoxin sequestering agentspigszearalenone |
| spellingShingle | Jong Young Ahn Jongkeon Kim Da Hyeon Cheong Hyosun Hong Jin Young Jeong Beob Gyun Kim An In Vitro Study on the Efficacy of Mycotoxin Sequestering Agents for Aflatoxin B1, Deoxynivalenol, and Zearalenone Animals aflatoxin B1 deoxynivalenol mycotoxin sequestering agents pigs zearalenone |
| title | An In Vitro Study on the Efficacy of Mycotoxin Sequestering Agents for Aflatoxin B1, Deoxynivalenol, and Zearalenone |
| title_full | An In Vitro Study on the Efficacy of Mycotoxin Sequestering Agents for Aflatoxin B1, Deoxynivalenol, and Zearalenone |
| title_fullStr | An In Vitro Study on the Efficacy of Mycotoxin Sequestering Agents for Aflatoxin B1, Deoxynivalenol, and Zearalenone |
| title_full_unstemmed | An In Vitro Study on the Efficacy of Mycotoxin Sequestering Agents for Aflatoxin B1, Deoxynivalenol, and Zearalenone |
| title_short | An In Vitro Study on the Efficacy of Mycotoxin Sequestering Agents for Aflatoxin B1, Deoxynivalenol, and Zearalenone |
| title_sort | in vitro study on the efficacy of mycotoxin sequestering agents for aflatoxin b1 deoxynivalenol and zearalenone |
| topic | aflatoxin B1 deoxynivalenol mycotoxin sequestering agents pigs zearalenone |
| url | https://www.mdpi.com/2076-2615/12/3/333 |
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