Base excess and pH as predictors of outcomes in secondary peritonitis in a resource limited setting - A prospective study
Background: Estimation of the serum pH and base excess as determinants of the adequacy of resuscitation may predict the patient outcome in peritonitis. Materials, Patients and Methods: This was a prospective study conducted in University College Hospital, Ibadan, on patients from 18 years and above...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Journal of Clinical Sciences |
| Subjects: | |
| Online Access: | http://www.jcsjournal.org/article.asp?issn=2468-6859;year=2020;volume=17;issue=4;spage=145;epage=149;aulast=Afuwape |
| _version_ | 1818265095497580544 |
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| author | O Oludolapo Afuwape Omobolaji Ayandipo Samuel Aroso |
| author_facet | O Oludolapo Afuwape Omobolaji Ayandipo Samuel Aroso |
| author_sort | O Oludolapo Afuwape |
| collection | DOAJ |
| description | Background: Estimation of the serum pH and base excess as determinants of the adequacy of resuscitation may predict the patient outcome in peritonitis. Materials, Patients and Methods: This was a prospective study conducted in University College Hospital, Ibadan, on patients from 18 years and above with diagnosis of secondary peritonitis who had exploratory laparotomy over a 4-month period (January to April 2017). The patients' biodata, pulse rate, blood pressure, and clinical diagnosis were documented. At presentation, the patients were resuscitated with intravenous normal saline and broad-spectrum antibiotics. Each patient had measurements of acid-base status, and pH analyzed at presentation and in the immediate postoperative period (within 1 h) using the I-STAT point of care device. They were followed up for 48 h after the surgery. The changes in base excess and serum pH in survivors and nonsurvivors were described at 48 h after surgery. This was statistically compared using SPSS version 20 (Chicago, IL, USA). Results: A total of 45 patients were recruited comprising 37 males and 8 female patients. The mean age was 40.86 ± 15.45 years. The mean admission base excess was −4.76 ± 5.41. The mean admission pH was 7.41 ± 0.07. There were 28 (62%) survivors and 17 (38%) mortalities. The pH on admission and base excess values and after surgery demonstrated statistical significance in survivors and nonsurvivors. Conclusion: Changes in base excess and serum pH values are plausible outcome markers in patients with peritonitis resuscitated with early goal-directed therapy. |
| first_indexed | 2024-12-12T19:45:21Z |
| format | Article |
| id | doaj.art-acebada1c6664150948e53bac1057c9a |
| institution | Directory Open Access Journal |
| issn | 2468-6859 2408-7408 |
| language | English |
| last_indexed | 2024-12-12T19:45:21Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Clinical Sciences |
| spelling | doaj.art-acebada1c6664150948e53bac1057c9a2022-12-22T00:14:06ZengWolters Kluwer Medknow PublicationsJournal of Clinical Sciences2468-68592408-74082020-01-0117414514910.4103/jcls.jcls_18_20Base excess and pH as predictors of outcomes in secondary peritonitis in a resource limited setting - A prospective studyO Oludolapo AfuwapeOmobolaji AyandipoSamuel ArosoBackground: Estimation of the serum pH and base excess as determinants of the adequacy of resuscitation may predict the patient outcome in peritonitis. Materials, Patients and Methods: This was a prospective study conducted in University College Hospital, Ibadan, on patients from 18 years and above with diagnosis of secondary peritonitis who had exploratory laparotomy over a 4-month period (January to April 2017). The patients' biodata, pulse rate, blood pressure, and clinical diagnosis were documented. At presentation, the patients were resuscitated with intravenous normal saline and broad-spectrum antibiotics. Each patient had measurements of acid-base status, and pH analyzed at presentation and in the immediate postoperative period (within 1 h) using the I-STAT point of care device. They were followed up for 48 h after the surgery. The changes in base excess and serum pH in survivors and nonsurvivors were described at 48 h after surgery. This was statistically compared using SPSS version 20 (Chicago, IL, USA). Results: A total of 45 patients were recruited comprising 37 males and 8 female patients. The mean age was 40.86 ± 15.45 years. The mean admission base excess was −4.76 ± 5.41. The mean admission pH was 7.41 ± 0.07. There were 28 (62%) survivors and 17 (38%) mortalities. The pH on admission and base excess values and after surgery demonstrated statistical significance in survivors and nonsurvivors. Conclusion: Changes in base excess and serum pH values are plausible outcome markers in patients with peritonitis resuscitated with early goal-directed therapy.http://www.jcsjournal.org/article.asp?issn=2468-6859;year=2020;volume=17;issue=4;spage=145;epage=149;aulast=Afuwapeacidosisoutcomeperitonitis |
| spellingShingle | O Oludolapo Afuwape Omobolaji Ayandipo Samuel Aroso Base excess and pH as predictors of outcomes in secondary peritonitis in a resource limited setting - A prospective study Journal of Clinical Sciences acidosis outcome peritonitis |
| title | Base excess and pH as predictors of outcomes in secondary peritonitis in a resource limited setting - A prospective study |
| title_full | Base excess and pH as predictors of outcomes in secondary peritonitis in a resource limited setting - A prospective study |
| title_fullStr | Base excess and pH as predictors of outcomes in secondary peritonitis in a resource limited setting - A prospective study |
| title_full_unstemmed | Base excess and pH as predictors of outcomes in secondary peritonitis in a resource limited setting - A prospective study |
| title_short | Base excess and pH as predictors of outcomes in secondary peritonitis in a resource limited setting - A prospective study |
| title_sort | base excess and ph as predictors of outcomes in secondary peritonitis in a resource limited setting a prospective study |
| topic | acidosis outcome peritonitis |
| url | http://www.jcsjournal.org/article.asp?issn=2468-6859;year=2020;volume=17;issue=4;spage=145;epage=149;aulast=Afuwape |
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