Evidence that the loss of colonic anti-microbial peptides may promote dysbiotic Gram-negative inflammaging-associated bacteria in aging mice

Evidence that the loss of colonic anti-microbial peptides may promote dysbiotic Gram-negative inflammaging-associated bacteria in aging mice

Introduction: Aging studies in humans and mice have played a key role in understanding the intestinal microbiome and an increased abundance of “inflammaging” Gram-negative (Gn) bacteria. The mechanisms underlying this inflammatory profile in the aging microbiome are unknown. We tested the hypothesis...

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Bibliographic Details
Main Authors: Christopher B. Forsyth, Maliha Shaikh, Phillip A. Engen, Fabian Preuss, Ankur Naqib, Breanna A. Palmen, Stefan J. Green, Lijuan Zhang, Zlata R. Bogin, Kristi Lawrence, Deepak Sharma, Garth R. Swanson, Faraz Bishehsari, Robin M. Voigt, Ali Keshavarzian
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Aging
Subjects:
aging
tight junction
microbiota
gene expression
anti-microbial peptides
dysbiosis
Online Access:https://www.frontiersin.org/articles/10.3389/fragi.2024.1352299/full

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