The Glucose-Regulated MiR-483-3p Influences Key Signaling Pathways in Cancer
The hsa-mir-483 gene, located within the IGF2 locus, transcribes for two mature microRNAs, miR-483-5p and miR-483-3p. This gene, whose regulation is mediated by the the CTNNB1/USF1 complex, shows an independent expression from its host gene IGF2. The miR-483-3p affects the Wnt/β-catenin, th...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2018-06-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6694/10/6/181 |
| _version_ | 1797714719591628800 |
|---|---|
| author | Felice Pepe Rosa Visone Angelo Veronese |
| author_facet | Felice Pepe Rosa Visone Angelo Veronese |
| author_sort | Felice Pepe |
| collection | DOAJ |
| description | The hsa-mir-483 gene, located within the IGF2 locus, transcribes for two mature microRNAs, miR-483-5p and miR-483-3p. This gene, whose regulation is mediated by the the CTNNB1/USF1 complex, shows an independent expression from its host gene IGF2. The miR-483-3p affects the Wnt/β-catenin, the TGF-β, and the TP53 signaling pathways by targeting several genes as CTNNB1, SMAD4, IGF1, and BBC3. Accordingly, miR-483-3p is associated with various tissues specific physiological properties as insulin and melanin production, as well as with cellular physiological functions such as wounding, differentiation, proliferation, and survival. Deregulation of miR-483-3p is observed in different types of cancer, and its overexpression can inhibit the pro-apoptotic pathway induced by the TP53 target effectors. As a result, the oncogenic characteristics of miR-483-3p are linked to the effect of some of the most relevant cancer-related genes, TP53 and CTNNB1, as well as to one of the most important cancer hallmark: the aberrant glucose metabolism of tumor cells. In this review, we summarize the recent findings regarding the miR-483-3p, to elucidate its functional role in physiological and pathological contexts, focusing overall on its involvement in cancer and in the TP53 pathway. |
| first_indexed | 2024-03-12T07:56:07Z |
| format | Article |
| id | doaj.art-aced2ec19caf480fb5b6c7c78d50cb4d |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T07:56:07Z |
| publishDate | 2018-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-aced2ec19caf480fb5b6c7c78d50cb4d2023-09-02T20:13:41ZengMDPI AGCancers2072-66942018-06-0110618110.3390/cancers10060181cancers10060181The Glucose-Regulated MiR-483-3p Influences Key Signaling Pathways in CancerFelice Pepe0Rosa Visone1Angelo Veronese2Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USAAgeing Research Center and Translational Medicine-CeSI-MeT, 66100 Chieti, ItalyAgeing Research Center and Translational Medicine-CeSI-MeT, 66100 Chieti, ItalyThe hsa-mir-483 gene, located within the IGF2 locus, transcribes for two mature microRNAs, miR-483-5p and miR-483-3p. This gene, whose regulation is mediated by the the CTNNB1/USF1 complex, shows an independent expression from its host gene IGF2. The miR-483-3p affects the Wnt/β-catenin, the TGF-β, and the TP53 signaling pathways by targeting several genes as CTNNB1, SMAD4, IGF1, and BBC3. Accordingly, miR-483-3p is associated with various tissues specific physiological properties as insulin and melanin production, as well as with cellular physiological functions such as wounding, differentiation, proliferation, and survival. Deregulation of miR-483-3p is observed in different types of cancer, and its overexpression can inhibit the pro-apoptotic pathway induced by the TP53 target effectors. As a result, the oncogenic characteristics of miR-483-3p are linked to the effect of some of the most relevant cancer-related genes, TP53 and CTNNB1, as well as to one of the most important cancer hallmark: the aberrant glucose metabolism of tumor cells. In this review, we summarize the recent findings regarding the miR-483-3p, to elucidate its functional role in physiological and pathological contexts, focusing overall on its involvement in cancer and in the TP53 pathway.http://www.mdpi.com/2072-6694/10/6/181miR-483-3pmetabolismTP53CTNNB1chemoresistancecancermiR-145-5p |
| spellingShingle | Felice Pepe Rosa Visone Angelo Veronese The Glucose-Regulated MiR-483-3p Influences Key Signaling Pathways in Cancer Cancers miR-483-3p metabolism TP53 CTNNB1 chemoresistance cancer miR-145-5p |
| title | The Glucose-Regulated MiR-483-3p Influences Key Signaling Pathways in Cancer |
| title_full | The Glucose-Regulated MiR-483-3p Influences Key Signaling Pathways in Cancer |
| title_fullStr | The Glucose-Regulated MiR-483-3p Influences Key Signaling Pathways in Cancer |
| title_full_unstemmed | The Glucose-Regulated MiR-483-3p Influences Key Signaling Pathways in Cancer |
| title_short | The Glucose-Regulated MiR-483-3p Influences Key Signaling Pathways in Cancer |
| title_sort | glucose regulated mir 483 3p influences key signaling pathways in cancer |
| topic | miR-483-3p metabolism TP53 CTNNB1 chemoresistance cancer miR-145-5p |
| url | http://www.mdpi.com/2072-6694/10/6/181 |
| work_keys_str_mv | AT felicepepe theglucoseregulatedmir4833pinfluenceskeysignalingpathwaysincancer AT rosavisone theglucoseregulatedmir4833pinfluenceskeysignalingpathwaysincancer AT angeloveronese theglucoseregulatedmir4833pinfluenceskeysignalingpathwaysincancer AT felicepepe glucoseregulatedmir4833pinfluenceskeysignalingpathwaysincancer AT rosavisone glucoseregulatedmir4833pinfluenceskeysignalingpathwaysincancer AT angeloveronese glucoseregulatedmir4833pinfluenceskeysignalingpathwaysincancer |