Evaluation of performance for malaria diagnosis in health facilities by five provincial reference laboratories of China
IntroductionThe provincial malaria diagnosis reference laboratories review and assess malaria cases diagnosed in health facilities for supporting the malaria elimination efforts and preventing re-transmission of imported malaria. The study aimed to evaluate the detection capability of malaria diagno...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-09-01
|
| Series: | Frontiers in Public Health |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1243642/full |
| _version_ | 1797671416057823232 |
|---|---|
| author | Xuan Zhang Jingjing Jiang Yuan Sui Hui Yan Jing Xia Ying Liu Lingcong Sun Xiaoxiao Wang Jutta Marfurt Jutta Marfurt Shenning Lu Shizhu Li Wei Ruan Duoquan Wang |
| author_facet | Xuan Zhang Jingjing Jiang Yuan Sui Hui Yan Jing Xia Ying Liu Lingcong Sun Xiaoxiao Wang Jutta Marfurt Jutta Marfurt Shenning Lu Shizhu Li Wei Ruan Duoquan Wang |
| author_sort | Xuan Zhang |
| collection | DOAJ |
| description | IntroductionThe provincial malaria diagnosis reference laboratories review and assess malaria cases diagnosed in health facilities for supporting the malaria elimination efforts and preventing re-transmission of imported malaria. The study aimed to evaluate the detection capability of malaria diagnosis in China from 2014 to 2021.MethodsData on malaria cases reported in the provincial-level administrative divisions (PLADs) of Anhui, Henan, Hubei, Guangxi, and Zhejiang from 2014 to 2021 were collected and analyzed.ResultsIn total, 5,770 malaria cases were reported from 2014 to 2021, and 99.05% (5,715/5,770) were submitted to the provincial malaria diagnosis reference laboratories. The median time between malaria cases being reported and the samples being received by reference laboratories was 6 days (Interquartile range, IQR:3–12 days) from 2017 to 2021. Diagnosis of 5,680 samples in the laboratory were confirmed by provincial reference laboratories, including 3,970 cases of Plasmodium falciparum, 414 of P. vivax, 1,055 of P. ovale, 158 of P. malariae, 1 of P. knowlesi, and 82 of mixed infections. Plasmodium species of 5,141 confirmed cases were consistent with the initial diagnosis, with a species accuracy rate of 90.53% (5,141/5,679). The accuracy of P. falciparum diagnosis in health facilities was higher than that of non-falciparum species. The inconsistency between microscopy and nested polymerase chain reaction (nPCR) results of confirmatory diagnosis was mainly in malaria-positive versus malaria-negative cases, as well as in mixed versus single infection cases.ConclusionThe provincial malaria diagnosis reference laboratories have played an important role in ensuring the accuracy and reliability of Plasmodium diagnosis in health facilities. However, the results of this study imply that capacity training for the identification of Plasmodium species in health facilities is warranted. |
| first_indexed | 2024-03-11T21:15:12Z |
| format | Article |
| id | doaj.art-acedfbb9f2834687842a2bb55023c05a |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-03-11T21:15:12Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-acedfbb9f2834687842a2bb55023c05a2023-09-29T04:48:59ZengFrontiers Media S.A.Frontiers in Public Health2296-25652023-09-011110.3389/fpubh.2023.12436421243642Evaluation of performance for malaria diagnosis in health facilities by five provincial reference laboratories of ChinaXuan Zhang0Jingjing Jiang1Yuan Sui2Hui Yan3Jing Xia4Ying Liu5Lingcong Sun6Xiaoxiao Wang7Jutta Marfurt8Jutta Marfurt9Shenning Lu10Shizhu Li11Wei Ruan12Duoquan Wang13Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, ChinaAnhui Provincial Center for Disease Control and Prevention, Hefei, ChinaBrown School, Washington University, St. Louis, MO, United StatesGuangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning, ChinaHubei Provincial Center for Disease Control and Prevention, Wuhan, ChinaHenan Provincial Center for Disease Control and Prevention, Zhengzhou, ChinaHubei Provincial Center for Disease Control and Prevention, Wuhan, ChinaZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, ChinaGlobal and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT, AustraliaCollege of Medicine and Public Health, Flinders University, Darwin, NT, AustraliaNational Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Center for Tropical Diseases, National Center for International Research on Tropical Diseases, Shanghai, ChinaNational Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Center for Tropical Diseases, National Center for International Research on Tropical Diseases, Shanghai, ChinaZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, ChinaNational Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Center for Tropical Diseases, National Center for International Research on Tropical Diseases, Shanghai, ChinaIntroductionThe provincial malaria diagnosis reference laboratories review and assess malaria cases diagnosed in health facilities for supporting the malaria elimination efforts and preventing re-transmission of imported malaria. The study aimed to evaluate the detection capability of malaria diagnosis in China from 2014 to 2021.MethodsData on malaria cases reported in the provincial-level administrative divisions (PLADs) of Anhui, Henan, Hubei, Guangxi, and Zhejiang from 2014 to 2021 were collected and analyzed.ResultsIn total, 5,770 malaria cases were reported from 2014 to 2021, and 99.05% (5,715/5,770) were submitted to the provincial malaria diagnosis reference laboratories. The median time between malaria cases being reported and the samples being received by reference laboratories was 6 days (Interquartile range, IQR:3–12 days) from 2017 to 2021. Diagnosis of 5,680 samples in the laboratory were confirmed by provincial reference laboratories, including 3,970 cases of Plasmodium falciparum, 414 of P. vivax, 1,055 of P. ovale, 158 of P. malariae, 1 of P. knowlesi, and 82 of mixed infections. Plasmodium species of 5,141 confirmed cases were consistent with the initial diagnosis, with a species accuracy rate of 90.53% (5,141/5,679). The accuracy of P. falciparum diagnosis in health facilities was higher than that of non-falciparum species. The inconsistency between microscopy and nested polymerase chain reaction (nPCR) results of confirmatory diagnosis was mainly in malaria-positive versus malaria-negative cases, as well as in mixed versus single infection cases.ConclusionThe provincial malaria diagnosis reference laboratories have played an important role in ensuring the accuracy and reliability of Plasmodium diagnosis in health facilities. However, the results of this study imply that capacity training for the identification of Plasmodium species in health facilities is warranted.https://www.frontiersin.org/articles/10.3389/fpubh.2023.1243642/fullmalarialaboratory diagnosisaccuracyreference laboratoryChina |
| spellingShingle | Xuan Zhang Jingjing Jiang Yuan Sui Hui Yan Jing Xia Ying Liu Lingcong Sun Xiaoxiao Wang Jutta Marfurt Jutta Marfurt Shenning Lu Shizhu Li Wei Ruan Duoquan Wang Evaluation of performance for malaria diagnosis in health facilities by five provincial reference laboratories of China Frontiers in Public Health malaria laboratory diagnosis accuracy reference laboratory China |
| title | Evaluation of performance for malaria diagnosis in health facilities by five provincial reference laboratories of China |
| title_full | Evaluation of performance for malaria diagnosis in health facilities by five provincial reference laboratories of China |
| title_fullStr | Evaluation of performance for malaria diagnosis in health facilities by five provincial reference laboratories of China |
| title_full_unstemmed | Evaluation of performance for malaria diagnosis in health facilities by five provincial reference laboratories of China |
| title_short | Evaluation of performance for malaria diagnosis in health facilities by five provincial reference laboratories of China |
| title_sort | evaluation of performance for malaria diagnosis in health facilities by five provincial reference laboratories of china |
| topic | malaria laboratory diagnosis accuracy reference laboratory China |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1243642/full |
| work_keys_str_mv | AT xuanzhang evaluationofperformanceformalariadiagnosisinhealthfacilitiesbyfiveprovincialreferencelaboratoriesofchina AT jingjingjiang evaluationofperformanceformalariadiagnosisinhealthfacilitiesbyfiveprovincialreferencelaboratoriesofchina AT yuansui evaluationofperformanceformalariadiagnosisinhealthfacilitiesbyfiveprovincialreferencelaboratoriesofchina AT huiyan evaluationofperformanceformalariadiagnosisinhealthfacilitiesbyfiveprovincialreferencelaboratoriesofchina AT jingxia evaluationofperformanceformalariadiagnosisinhealthfacilitiesbyfiveprovincialreferencelaboratoriesofchina AT yingliu evaluationofperformanceformalariadiagnosisinhealthfacilitiesbyfiveprovincialreferencelaboratoriesofchina AT lingcongsun evaluationofperformanceformalariadiagnosisinhealthfacilitiesbyfiveprovincialreferencelaboratoriesofchina AT xiaoxiaowang evaluationofperformanceformalariadiagnosisinhealthfacilitiesbyfiveprovincialreferencelaboratoriesofchina AT juttamarfurt evaluationofperformanceformalariadiagnosisinhealthfacilitiesbyfiveprovincialreferencelaboratoriesofchina AT juttamarfurt evaluationofperformanceformalariadiagnosisinhealthfacilitiesbyfiveprovincialreferencelaboratoriesofchina AT shenninglu evaluationofperformanceformalariadiagnosisinhealthfacilitiesbyfiveprovincialreferencelaboratoriesofchina AT shizhuli evaluationofperformanceformalariadiagnosisinhealthfacilitiesbyfiveprovincialreferencelaboratoriesofchina AT weiruan evaluationofperformanceformalariadiagnosisinhealthfacilitiesbyfiveprovincialreferencelaboratoriesofchina AT duoquanwang evaluationofperformanceformalariadiagnosisinhealthfacilitiesbyfiveprovincialreferencelaboratoriesofchina |