Bacterial extracellular vesicles and their novel therapeutic applications in health and cancer
Bacterial cells communicate with host cells and other bacteria through the release of membrane vesicles known as bacterial extracellular vesicles (BEV). BEV are established mediators of intracellular signaling, stress tolerance, horizontal gene transfer, immune stimulation and pathogenicity. Both Gr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.962216/full |
| _version_ | 1828335898731741184 |
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| author | Niloufar Hosseini-Giv Alyza Basas Chloe Hicks Emad El-Omar Fatima El-Assaad Elham Hosseini-Beheshti Elham Hosseini-Beheshti |
| author_facet | Niloufar Hosseini-Giv Alyza Basas Chloe Hicks Emad El-Omar Fatima El-Assaad Elham Hosseini-Beheshti Elham Hosseini-Beheshti |
| author_sort | Niloufar Hosseini-Giv |
| collection | DOAJ |
| description | Bacterial cells communicate with host cells and other bacteria through the release of membrane vesicles known as bacterial extracellular vesicles (BEV). BEV are established mediators of intracellular signaling, stress tolerance, horizontal gene transfer, immune stimulation and pathogenicity. Both Gram-positive and Gram-negative bacteria produce extracellular vesicles through different mechanisms based on cell structure. BEV contain and transfer different types of cargo such as nucleic acids, proteins and lipids, which are used to interact with and affect host cells such as cytotoxicity and immunomodulation. The role of these membranous microvesicles in host communication, intra- and inter-species cell interaction and signaling, and contribution to various diseases have been well demonstrated. Due to their structure, these vesicles can be easily engineered to be utilized for clinical application, as shown with its role in vaccine therapy, and could be used as a diagnostic and cancer drug delivery tool in the future. However, like other novel therapeutic approaches, further investigation and standardization is imperative for BEV to become a routine vector or a conventional treatment method. |
| first_indexed | 2024-04-13T21:52:58Z |
| format | Article |
| id | doaj.art-acee48a0df1340beb68306e2f9cc1115 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-13T21:52:58Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-acee48a0df1340beb68306e2f9cc11152022-12-22T02:28:22ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-11-011210.3389/fcimb.2022.962216962216Bacterial extracellular vesicles and their novel therapeutic applications in health and cancerNiloufar Hosseini-Giv0Alyza Basas1Chloe Hicks2Emad El-Omar3Fatima El-Assaad4Elham Hosseini-Beheshti5Elham Hosseini-Beheshti6Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, IranUNSW Microbiome Research Centre, St George and Sutherland Clinical Campuses, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, AustraliaUNSW Microbiome Research Centre, St George and Sutherland Clinical Campuses, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, AustraliaUNSW Microbiome Research Centre, St George and Sutherland Clinical Campuses, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, AustraliaUNSW Microbiome Research Centre, St George and Sutherland Clinical Campuses, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, AustraliaSchool of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, AustraliaThe Sydney Nano Institute, The University of Sydney, Sydney, NSW, AustraliaBacterial cells communicate with host cells and other bacteria through the release of membrane vesicles known as bacterial extracellular vesicles (BEV). BEV are established mediators of intracellular signaling, stress tolerance, horizontal gene transfer, immune stimulation and pathogenicity. Both Gram-positive and Gram-negative bacteria produce extracellular vesicles through different mechanisms based on cell structure. BEV contain and transfer different types of cargo such as nucleic acids, proteins and lipids, which are used to interact with and affect host cells such as cytotoxicity and immunomodulation. The role of these membranous microvesicles in host communication, intra- and inter-species cell interaction and signaling, and contribution to various diseases have been well demonstrated. Due to their structure, these vesicles can be easily engineered to be utilized for clinical application, as shown with its role in vaccine therapy, and could be used as a diagnostic and cancer drug delivery tool in the future. However, like other novel therapeutic approaches, further investigation and standardization is imperative for BEV to become a routine vector or a conventional treatment method.https://www.frontiersin.org/articles/10.3389/fcimb.2022.962216/fullbacterial extracellular vesiclesmicrovesiclesouter membrane vesiclescell cargohost interactionsinfection |
| spellingShingle | Niloufar Hosseini-Giv Alyza Basas Chloe Hicks Emad El-Omar Fatima El-Assaad Elham Hosseini-Beheshti Elham Hosseini-Beheshti Bacterial extracellular vesicles and their novel therapeutic applications in health and cancer Frontiers in Cellular and Infection Microbiology bacterial extracellular vesicles microvesicles outer membrane vesicles cell cargo host interactions infection |
| title | Bacterial extracellular vesicles and their novel therapeutic applications in health and cancer |
| title_full | Bacterial extracellular vesicles and their novel therapeutic applications in health and cancer |
| title_fullStr | Bacterial extracellular vesicles and their novel therapeutic applications in health and cancer |
| title_full_unstemmed | Bacterial extracellular vesicles and their novel therapeutic applications in health and cancer |
| title_short | Bacterial extracellular vesicles and their novel therapeutic applications in health and cancer |
| title_sort | bacterial extracellular vesicles and their novel therapeutic applications in health and cancer |
| topic | bacterial extracellular vesicles microvesicles outer membrane vesicles cell cargo host interactions infection |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.962216/full |
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