Intratracheal exposure to polyhexamethylene guanidine phosphate disrupts coordinate regulation of FXR-SHP-mediated cholesterol and bile acid homeostasis in mouse liver

Intratracheal exposure to polyhexamethylene guanidine phosphate disrupts coordinate regulation of FXR-SHP-mediated cholesterol and bile acid homeostasis in mouse liver

A public health crisis in the form of a significant incidence of fatal pulmonary disease caused by repeated use of humidifier disinfectants containing polyhexamethylene guanidine phosphate (PHMG) recently arose in Korea. Although the mechanisms of pulmonary fibrosis following respiratory exposure to...

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Bibliographic Details
Main Authors: You-Jin Choi, Hyo-Seon Yang, Yunfan Zhang, Wonseok Lee, Sung Ho Yun, Yoon Ah Nam, Gakyung Lee, Byung Hwa Jung, Tong-Shin Chang, Kyuhong Lee, Byung-Hoon Lee
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Polyhexamethylene guanidine phosphate (PHMG)
Distant-organ effect
Cholesterol synthesis
Bile acid homeostasis
Farnesoid X receptor (FXR)
Small heterodimer partner (SHP)
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651322010533

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http://www.sciencedirect.com/science/article/pii/S0147651322010533

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