Polyethylene glycol-coated ultrasmall superparamagnetic iron oxide nanoparticles-coupled sialyl Lewis X nanotheranostic platform for nasopharyngeal carcinoma imaging and photothermal therapy
Abstract Background Nasopharyngeal carcinoma (NPC) is a type of head and neck malignant tumor with a high incidence in specific regional distribution, and its traditional therapies face some challenges. It has become an urgent need to seek new therapeutic strategies without or with low toxicity and...
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| Format: | Article |
| Language: | English |
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BMC
2021-06-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-021-00918-0 |
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| author | Qinmin Liu Lijuan Liu Chunwei Mo Xiao Zhou Dongming Chen Yu He Hailu He Wei Kang Yongfeng Zhao Guanqiao Jin |
| author_facet | Qinmin Liu Lijuan Liu Chunwei Mo Xiao Zhou Dongming Chen Yu He Hailu He Wei Kang Yongfeng Zhao Guanqiao Jin |
| author_sort | Qinmin Liu |
| collection | DOAJ |
| description | Abstract Background Nasopharyngeal carcinoma (NPC) is a type of head and neck malignant tumor with a high incidence in specific regional distribution, and its traditional therapies face some challenges. It has become an urgent need to seek new therapeutic strategies without or with low toxicity and side effects. At present, more and more researchers has been attracting attention by nanotheranostic platform. Therefore, our team synthesized the polyethylene glycol-coated ultrasmall superparamagnetic iron oxide nanoparticles-coupled sialyl Lewis X (USPIO-PEG-sLex) nanotheranostic platform with high temperature pyrolysis. Results The USPIO-PEG-sLex nanoparticles had excellent photothermal conversion property, and the temperature of USPIO-PEG-sLex nanoparticles solution increased with its concentration and power density of near-infrared (NIR) on 808 nm wavelengths. Five USPIO-PEG-sLex nanoparticles with different concentrations of 0 mg/ml, 0.025 mg/ml, 0.05 mg/ml, 0.1 mg/ml and 0.2 mg/ml were prepared. The biological toxicity results showed that the viability of NPC 5-8F cells is related to the concentration of USPIO-PEG-sLex nanoparticles and the culture time (P < 0.001). The results of photothermal therapy (PTT) in vitro indicated that the viability of 5-8F cells decreased significantly with the concentration of USPIO-PEG-sLex nanoparticles increases (P < 0.001), and the viability of NPC 5-8F cells were 91.04% ± 5.20%, 77.83% ± 3.01%, 73.48% ± 5.55%, 59.50% ± 10.98%, 17.11% ± 3.14%, respectively. The USPIO-PEG-sLex nanoparticles could target the tumor area, and reduce the T2* value of tumor tissue. The T2* values of tumor pre- and post-injection were 30.870 ± 5.604 and 18.335 ± 4.351, respectively (P < 0.001). In addition, USPIO-PEG-sLex nanoparticles as a photothermal agent for PTT could effectively inhibit tumor progression. The ratio of volume change between tail vein injection group, control group, nanoparticles without laser irradiation group and blank group after 5 treatments were 3.04 ± 0.57, 5.80 ± 1.06, 8.09 ± 1.96, 7.89 ± 2.20, respectively (P < 0.001). Conclusions Our synthesized USPIO-PEG-sLex nanotheranostic platform, and it may be become a new strategy for the treatment of NPC. Graphic Abstract |
| first_indexed | 2024-04-12T05:35:53Z |
| format | Article |
| id | doaj.art-acf95fca330344c792c817e2f37e6ede |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-12T05:35:53Z |
| publishDate | 2021-06-01 |
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| series | Journal of Nanobiotechnology |
| spelling | doaj.art-acf95fca330344c792c817e2f37e6ede2022-12-22T03:45:51ZengBMCJournal of Nanobiotechnology1477-31552021-06-0119111410.1186/s12951-021-00918-0Polyethylene glycol-coated ultrasmall superparamagnetic iron oxide nanoparticles-coupled sialyl Lewis X nanotheranostic platform for nasopharyngeal carcinoma imaging and photothermal therapyQinmin Liu0Lijuan Liu1Chunwei Mo2Xiao Zhou3Dongming Chen4Yu He5Hailu He6Wei Kang7Yongfeng Zhao8Guanqiao Jin9Department of Radiology, Guangxi Medical University Cancer HospitalDepartment of Radiology, Guangxi Medical University Cancer HospitalDepartment of Radiology, Guangxi Medical University Cancer HospitalDepartment of Radiology, Guangxi Medical University Cancer HospitalDepartment of Radiology, Guangxi Medical University Cancer HospitalDepartment of Radiology, Guangxi Medical University Cancer HospitalDepartment of Radiology, Guangxi Medical University Cancer HospitalDepartment of Radiology, Guangxi Medical University Cancer HospitalDepartment of Chemistry and Biochemistry, Jackson State UniversityDepartment of Radiology, Guangxi Medical University Cancer HospitalAbstract Background Nasopharyngeal carcinoma (NPC) is a type of head and neck malignant tumor with a high incidence in specific regional distribution, and its traditional therapies face some challenges. It has become an urgent need to seek new therapeutic strategies without or with low toxicity and side effects. At present, more and more researchers has been attracting attention by nanotheranostic platform. Therefore, our team synthesized the polyethylene glycol-coated ultrasmall superparamagnetic iron oxide nanoparticles-coupled sialyl Lewis X (USPIO-PEG-sLex) nanotheranostic platform with high temperature pyrolysis. Results The USPIO-PEG-sLex nanoparticles had excellent photothermal conversion property, and the temperature of USPIO-PEG-sLex nanoparticles solution increased with its concentration and power density of near-infrared (NIR) on 808 nm wavelengths. Five USPIO-PEG-sLex nanoparticles with different concentrations of 0 mg/ml, 0.025 mg/ml, 0.05 mg/ml, 0.1 mg/ml and 0.2 mg/ml were prepared. The biological toxicity results showed that the viability of NPC 5-8F cells is related to the concentration of USPIO-PEG-sLex nanoparticles and the culture time (P < 0.001). The results of photothermal therapy (PTT) in vitro indicated that the viability of 5-8F cells decreased significantly with the concentration of USPIO-PEG-sLex nanoparticles increases (P < 0.001), and the viability of NPC 5-8F cells were 91.04% ± 5.20%, 77.83% ± 3.01%, 73.48% ± 5.55%, 59.50% ± 10.98%, 17.11% ± 3.14%, respectively. The USPIO-PEG-sLex nanoparticles could target the tumor area, and reduce the T2* value of tumor tissue. The T2* values of tumor pre- and post-injection were 30.870 ± 5.604 and 18.335 ± 4.351, respectively (P < 0.001). In addition, USPIO-PEG-sLex nanoparticles as a photothermal agent for PTT could effectively inhibit tumor progression. The ratio of volume change between tail vein injection group, control group, nanoparticles without laser irradiation group and blank group after 5 treatments were 3.04 ± 0.57, 5.80 ± 1.06, 8.09 ± 1.96, 7.89 ± 2.20, respectively (P < 0.001). Conclusions Our synthesized USPIO-PEG-sLex nanotheranostic platform, and it may be become a new strategy for the treatment of NPC. Graphic Abstracthttps://doi.org/10.1186/s12951-021-00918-0Nasopharyngeal carcinomaNanotheranostic platformUSPIO-PEG-sLexMagnetic resonance imagingPhotothermal therapy |
| spellingShingle | Qinmin Liu Lijuan Liu Chunwei Mo Xiao Zhou Dongming Chen Yu He Hailu He Wei Kang Yongfeng Zhao Guanqiao Jin Polyethylene glycol-coated ultrasmall superparamagnetic iron oxide nanoparticles-coupled sialyl Lewis X nanotheranostic platform for nasopharyngeal carcinoma imaging and photothermal therapy Journal of Nanobiotechnology Nasopharyngeal carcinoma Nanotheranostic platform USPIO-PEG-sLex Magnetic resonance imaging Photothermal therapy |
| title | Polyethylene glycol-coated ultrasmall superparamagnetic iron oxide nanoparticles-coupled sialyl Lewis X nanotheranostic platform for nasopharyngeal carcinoma imaging and photothermal therapy |
| title_full | Polyethylene glycol-coated ultrasmall superparamagnetic iron oxide nanoparticles-coupled sialyl Lewis X nanotheranostic platform for nasopharyngeal carcinoma imaging and photothermal therapy |
| title_fullStr | Polyethylene glycol-coated ultrasmall superparamagnetic iron oxide nanoparticles-coupled sialyl Lewis X nanotheranostic platform for nasopharyngeal carcinoma imaging and photothermal therapy |
| title_full_unstemmed | Polyethylene glycol-coated ultrasmall superparamagnetic iron oxide nanoparticles-coupled sialyl Lewis X nanotheranostic platform for nasopharyngeal carcinoma imaging and photothermal therapy |
| title_short | Polyethylene glycol-coated ultrasmall superparamagnetic iron oxide nanoparticles-coupled sialyl Lewis X nanotheranostic platform for nasopharyngeal carcinoma imaging and photothermal therapy |
| title_sort | polyethylene glycol coated ultrasmall superparamagnetic iron oxide nanoparticles coupled sialyl lewis x nanotheranostic platform for nasopharyngeal carcinoma imaging and photothermal therapy |
| topic | Nasopharyngeal carcinoma Nanotheranostic platform USPIO-PEG-sLex Magnetic resonance imaging Photothermal therapy |
| url | https://doi.org/10.1186/s12951-021-00918-0 |
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