Total Chemical Synthesis of Modified Histones

In the post-genome era, epigenetics has received increasing attentions in recent years. The post-translational modifications (PTMs) of four core histones play central roles in epigenetic regulation of eukaryotic genome by either directly altering the biophysical properties of nucleosomes or by recru...

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Bibliographic Details
Main Authors: Yun-Kun Qi, Hua-Song Ai, Yi-Ming Li, Baihui Yan
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Chemistry
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fchem.2018.00019/full