Incidence and risk factors for moderate and severe bronchopulmonary dysplasia in very low birth weight infants in two Croatian perinatal regions – a retrospective cohort study
Introduction: Bronchopulmonary dysplasia (BPD) is a significant cause of mortality and morbidity in preterm infants. The incidence of BPD varies widely between centers and is found in 20% to 40% of very low birth weight (VLBW) infants. Our work aimed to examine the incidence and risk factors for mod...
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| Format: | Article |
| Language: | English |
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Hygeia Press di Corridori Marinella
2019-04-01
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| Series: | Journal of Pediatric and Neonatal Individualized Medicine |
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| Online Access: | https://www.jpnim.com/index.php/jpnim/article/view/662 |
| _version_ | 1811221967019180032 |
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| author | Darjan Kardum Boris Filipović-Grčić Andrijana Müller Sandro Dessardo |
| author_facet | Darjan Kardum Boris Filipović-Grčić Andrijana Müller Sandro Dessardo |
| author_sort | Darjan Kardum |
| collection | DOAJ |
| description | Introduction: Bronchopulmonary dysplasia (BPD) is a significant cause of mortality and morbidity in preterm infants. The incidence of BPD varies widely between centers and is found in 20% to 40% of very low birth weight (VLBW) infants. Our work aimed to examine the incidence and risk factors for moderate and severe BPD in a population of VLBW infants.
Materials and methods: Demographic data, risk factors, incidence and severity of BPD were analyzed for 178 VLBW infants treated in two Croatian perinatal regions (2 level III neonatal units, 2 level II neonatal units and 5 level I neonatal wards) in the period from January 1, 2014 to December 31, 2016.
Results: The rate of BPD was 59.6% (106/178) which is significantly higher than reported earlier. Mild BPD accounted for 65.1% (69/106) and moderate/severe BPD is found in 34.9% (37/106) infants. Among infants with ≤ 28 weeks of gestation, the rate of moderate and severe BPD was 40.5% (30/74). Ultimate risk factors for the development of moderate/severe BPD were late-onset sepsis (p = 0.03; OR [95% CI]: 4.76 [1.22-18.5]), and higher initial neonatal risk as expressed by Critical Risk Index for Babies (CRIB) score (p < 0.001; OR [95% CI]: 1.73 [1.32-2.29]).
Conclusion: The incidence of moderate and severe BPD in our study group is higher than previously reported, and the majority of affected infants are < 29 weeks of gestation. The factors that had the strongest influence on the development of moderate and severe BPD were a higher initial neonatal risk as expressed by CRIB score and late-onset sepsis. |
| first_indexed | 2024-04-12T08:09:10Z |
| format | Article |
| id | doaj.art-acf9cf35b776421da3dfbb7b158e44e4 |
| institution | Directory Open Access Journal |
| issn | 2281-0692 |
| language | English |
| last_indexed | 2024-04-12T08:09:10Z |
| publishDate | 2019-04-01 |
| publisher | Hygeia Press di Corridori Marinella |
| record_format | Article |
| series | Journal of Pediatric and Neonatal Individualized Medicine |
| spelling | doaj.art-acf9cf35b776421da3dfbb7b158e44e42022-12-22T03:41:02ZengHygeia Press di Corridori MarinellaJournal of Pediatric and Neonatal Individualized Medicine2281-06922019-04-0181e080129e08012910.7363/080129559Incidence and risk factors for moderate and severe bronchopulmonary dysplasia in very low birth weight infants in two Croatian perinatal regions – a retrospective cohort studyDarjan Kardum0Boris Filipović-Grčić1Andrijana Müller2Sandro Dessardo3Neonatal Intensive Care Unit, Department of Pediatrics, University Hospital Osijek, Osijek, Croatia; School of Medicine, University J. J. Strossmayer Osijek, Osijek, CroatiaNeonatal Intensive Care Unit, Department of Pediatrics, University Hospital Zagreb, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, CroatiaDepartment of Gynecology and Obstetrics, University Hospital Osijek, Osijek, Croatia; School of Medicine, University J. J. Strossmayer Osijek, Osijek, CroatiaNeonatal and Pediatric Intensive Care Unit, Department of Pediatrics, University Hospital Rijeka, Rijeka, Croatia; School of Medicine, University of Rijeka, Rijeka, CroatiaIntroduction: Bronchopulmonary dysplasia (BPD) is a significant cause of mortality and morbidity in preterm infants. The incidence of BPD varies widely between centers and is found in 20% to 40% of very low birth weight (VLBW) infants. Our work aimed to examine the incidence and risk factors for moderate and severe BPD in a population of VLBW infants. Materials and methods: Demographic data, risk factors, incidence and severity of BPD were analyzed for 178 VLBW infants treated in two Croatian perinatal regions (2 level III neonatal units, 2 level II neonatal units and 5 level I neonatal wards) in the period from January 1, 2014 to December 31, 2016. Results: The rate of BPD was 59.6% (106/178) which is significantly higher than reported earlier. Mild BPD accounted for 65.1% (69/106) and moderate/severe BPD is found in 34.9% (37/106) infants. Among infants with ≤ 28 weeks of gestation, the rate of moderate and severe BPD was 40.5% (30/74). Ultimate risk factors for the development of moderate/severe BPD were late-onset sepsis (p = 0.03; OR [95% CI]: 4.76 [1.22-18.5]), and higher initial neonatal risk as expressed by Critical Risk Index for Babies (CRIB) score (p < 0.001; OR [95% CI]: 1.73 [1.32-2.29]). Conclusion: The incidence of moderate and severe BPD in our study group is higher than previously reported, and the majority of affected infants are < 29 weeks of gestation. The factors that had the strongest influence on the development of moderate and severe BPD were a higher initial neonatal risk as expressed by CRIB score and late-onset sepsis.https://www.jpnim.com/index.php/jpnim/article/view/662bronchopulmonary dysplasiavery low birth weight infantsrisk factorsincidencecrib scorelate-onset sepsis |
| spellingShingle | Darjan Kardum Boris Filipović-Grčić Andrijana Müller Sandro Dessardo Incidence and risk factors for moderate and severe bronchopulmonary dysplasia in very low birth weight infants in two Croatian perinatal regions – a retrospective cohort study Journal of Pediatric and Neonatal Individualized Medicine bronchopulmonary dysplasia very low birth weight infants risk factors incidence crib score late-onset sepsis |
| title | Incidence and risk factors for moderate and severe bronchopulmonary dysplasia in very low birth weight infants in two Croatian perinatal regions – a retrospective cohort study |
| title_full | Incidence and risk factors for moderate and severe bronchopulmonary dysplasia in very low birth weight infants in two Croatian perinatal regions – a retrospective cohort study |
| title_fullStr | Incidence and risk factors for moderate and severe bronchopulmonary dysplasia in very low birth weight infants in two Croatian perinatal regions – a retrospective cohort study |
| title_full_unstemmed | Incidence and risk factors for moderate and severe bronchopulmonary dysplasia in very low birth weight infants in two Croatian perinatal regions – a retrospective cohort study |
| title_short | Incidence and risk factors for moderate and severe bronchopulmonary dysplasia in very low birth weight infants in two Croatian perinatal regions – a retrospective cohort study |
| title_sort | incidence and risk factors for moderate and severe bronchopulmonary dysplasia in very low birth weight infants in two croatian perinatal regions a retrospective cohort study |
| topic | bronchopulmonary dysplasia very low birth weight infants risk factors incidence crib score late-onset sepsis |
| url | https://www.jpnim.com/index.php/jpnim/article/view/662 |
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