The association between angiotensin-converting enzyme insertion/deletion gene variant and risk of focal segmental glomerulosclerosis: a systematic review and meta-analysis
Background and objective : The association of the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism with the risk of focal segmental glomerulosclerosis (FSGS) is still controversial. A meta-analysis was performed to evaluate the association between ACE I/D gene polymorph...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publications
2011-12-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320311410584 |
| _version_ | 1797285413400870912 |
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| author | Tian-Biao Zhou Yuan-Han Qin Li-Na Su Feng-Ying Lei Wei-Fang Huang Yan-Jun Zhao Yu-Sheng Pang Kun-Peng Yang |
| author_facet | Tian-Biao Zhou Yuan-Han Qin Li-Na Su Feng-Ying Lei Wei-Fang Huang Yan-Jun Zhao Yu-Sheng Pang Kun-Peng Yang |
| author_sort | Tian-Biao Zhou |
| collection | DOAJ |
| description | Background and objective : The association of the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism with the risk of focal segmental glomerulosclerosis (FSGS) is still controversial. A meta-analysis was performed to evaluate the association between ACE I/D gene polymorphism and FSGS susceptibility. Method : We performed a predefined literature search and selection of eligible relevant studies to collect data from electronic databases. Results : In total, 12 articles were identified for the analysis of the association between ACE I/D gene polymorphism and FSGS risk. One report included an investigation in Arab and Jewish populations separately. Thus, there were seven reports in Asians, two in Caucasians, one in Africans, two in Arabs and one in Jews. In Asians, there was a markedly positive association between the D allele or DD genotype and FSGS susceptibility ( p = 0.008; p = 0.002), and the II genotype may play a protective role against FSGS onset ( p = 0.002). However, a link between ACE I/D gene polymorphism and FSGS risk was not found in Caucasians, Africans, Arabs or Jews (Caucasians: D: p = 0.11, DD: p = 0.19, II: p = 0.70; Africans: D: p = 0.40, DD: p = 0.49, II: p = 0.61; Arabs: D: p = 0.34, DD: p = 0.10, II: p = 0.42; Jews: D: p = 0.90, DD: p = 0.97, II: p = 0.83). Conclusion : The D allele or DD homozygosity may become a significant genetic molecular marker for the onset of FSGS in Asians, but not for Caucasians, Africans, Arabs or Jews. |
| first_indexed | 2024-03-07T18:02:51Z |
| format | Article |
| id | doaj.art-acf9d961ccac44bbbd88b9d271e6f6c9 |
| institution | Directory Open Access Journal |
| issn | 1470-3203 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T18:02:51Z |
| publishDate | 2011-12-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-acf9d961ccac44bbbd88b9d271e6f6c92024-03-02T10:24:03ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762011-12-011210.1177/1470320311410584The association between angiotensin-converting enzyme insertion/deletion gene variant and risk of focal segmental glomerulosclerosis: a systematic review and meta-analysisTian-Biao Zhou0Yuan-Han Qin1Li-Na Su2Feng-Ying Lei3Wei-Fang Huang4Yan-Jun Zhao5Yu-Sheng Pang6Kun-Peng Yang7Department of Pediatrics, The First Affiliated Hospital of GuangXi Medical University, NanNing, ChinaDepartment of Pediatrics, The First Affiliated Hospital of GuangXi Medical University, NanNing, ChinaDepartment of Pediatrics, The First Affiliated Hospital of GuangXi Medical University, NanNing, ChinaDepartment of Pediatrics, The First Affiliated Hospital of GuangXi Medical University, NanNing, ChinaDepartment of Pediatrics, The First Affiliated Hospital of GuangXi Medical University, NanNing, ChinaDepartment of Pediatrics, The First Affiliated Hospital of GuangXi Medical University, NanNing, ChinaDepartment of Pediatrics, The First Affiliated Hospital of GuangXi Medical University, NanNing, ChinaDepartment of internal medicine, Township Health Centers of ShilLing in LongQuan district, ChengDu, ChinaBackground and objective : The association of the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism with the risk of focal segmental glomerulosclerosis (FSGS) is still controversial. A meta-analysis was performed to evaluate the association between ACE I/D gene polymorphism and FSGS susceptibility. Method : We performed a predefined literature search and selection of eligible relevant studies to collect data from electronic databases. Results : In total, 12 articles were identified for the analysis of the association between ACE I/D gene polymorphism and FSGS risk. One report included an investigation in Arab and Jewish populations separately. Thus, there were seven reports in Asians, two in Caucasians, one in Africans, two in Arabs and one in Jews. In Asians, there was a markedly positive association between the D allele or DD genotype and FSGS susceptibility ( p = 0.008; p = 0.002), and the II genotype may play a protective role against FSGS onset ( p = 0.002). However, a link between ACE I/D gene polymorphism and FSGS risk was not found in Caucasians, Africans, Arabs or Jews (Caucasians: D: p = 0.11, DD: p = 0.19, II: p = 0.70; Africans: D: p = 0.40, DD: p = 0.49, II: p = 0.61; Arabs: D: p = 0.34, DD: p = 0.10, II: p = 0.42; Jews: D: p = 0.90, DD: p = 0.97, II: p = 0.83). Conclusion : The D allele or DD homozygosity may become a significant genetic molecular marker for the onset of FSGS in Asians, but not for Caucasians, Africans, Arabs or Jews.https://doi.org/10.1177/1470320311410584 |
| spellingShingle | Tian-Biao Zhou Yuan-Han Qin Li-Na Su Feng-Ying Lei Wei-Fang Huang Yan-Jun Zhao Yu-Sheng Pang Kun-Peng Yang The association between angiotensin-converting enzyme insertion/deletion gene variant and risk of focal segmental glomerulosclerosis: a systematic review and meta-analysis Journal of the Renin-Angiotensin-Aldosterone System |
| title | The association between angiotensin-converting enzyme insertion/deletion gene variant and risk of focal segmental glomerulosclerosis: a systematic review and meta-analysis |
| title_full | The association between angiotensin-converting enzyme insertion/deletion gene variant and risk of focal segmental glomerulosclerosis: a systematic review and meta-analysis |
| title_fullStr | The association between angiotensin-converting enzyme insertion/deletion gene variant and risk of focal segmental glomerulosclerosis: a systematic review and meta-analysis |
| title_full_unstemmed | The association between angiotensin-converting enzyme insertion/deletion gene variant and risk of focal segmental glomerulosclerosis: a systematic review and meta-analysis |
| title_short | The association between angiotensin-converting enzyme insertion/deletion gene variant and risk of focal segmental glomerulosclerosis: a systematic review and meta-analysis |
| title_sort | association between angiotensin converting enzyme insertion deletion gene variant and risk of focal segmental glomerulosclerosis a systematic review and meta analysis |
| url | https://doi.org/10.1177/1470320311410584 |
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