FEV Maintains Homing and Expansion by Activating ITGA4 Transcription in Primary and Relapsed AML

FEV Maintains Homing and Expansion by Activating ITGA4 Transcription in Primary and Relapsed AML

Acute myeloid leukemia (AML) is an aggressive hematological malignancy that recurs in approximately 50% of cases. Elevated homing and uncontrolled expansion are characteristics of AML cells. Here, we identified that Fifth Ewing Variant (FEV) regulates the homing and expansion of AML cells. We found...

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Bibliographic Details
Main Authors: Jubin Zhang, Lijuan Qi, Tanzhen Wang, Jingnan An, Biqi Zhou, Yanglan Fang, Yujie Liu, Meng Shan, Dengli Hong, Depei Wu, Yang Xu, Tianhui Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Oncology
Subjects:
FEV
AML (acute myeloid leukemia)
ITGA4
homing
expansion
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.890346/full

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