Serological evaluation of immune effect of inactivated COVID-19 vaccine in adult population in Deqing County， Huzhou City， Zhejiang Province
ObjectiveTo investigate the specific anti-SARS-CoV-2 antibody in adults and above after initial vaccination with inactivated COVID-19 vaccine， and determine the influencing factors.MethodsIn this study， residents aged 18 and above who had completed two doses of inactivated COVID-19 vaccine in Deqing...
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| Format: | Article |
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Shanghai Preventive Medicine Association
2022-11-01
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| Series: | Shanghai yufang yixue |
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| Online Access: | http://www.sjpm.org.cn/article/doi/10.19428/j.cnki.sjpm.2022.22105 |
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| author | MAO Chuanwu CHEN Yingfeng ZHANG Li XIE Yuyang DONG Xiaolian JIANG Lufang JIANG Qingwu |
| author_facet | MAO Chuanwu CHEN Yingfeng ZHANG Li XIE Yuyang DONG Xiaolian JIANG Lufang JIANG Qingwu |
| author_sort | MAO Chuanwu |
| collection | DOAJ |
| description | ObjectiveTo investigate the specific anti-SARS-CoV-2 antibody in adults and above after initial vaccination with inactivated COVID-19 vaccine， and determine the influencing factors.MethodsIn this study， residents aged 18 and above who had completed two doses of inactivated COVID-19 vaccine in Deqing County， Huzhou City， Zhejiang Province were included. Information such as gender， age， type of vaccine and vaccination time were collected， and serum specimens were sampled. Anti-SARS-CoV-2 receptor binding domain （RBD） antibody was quantitatively examined by enzyma-linked immunosorbent assay （ELISA） and influencing factors were determined.ResultsThe median concentration of anti-SARS-CoV-2 IgG antibody in the residents vaccinated with an inactivated booster vaccine was higher than that in those vaccinated with only two doses of COVID-19 vaccine or single dose （P<0.05）. The median concentration of IgG antibody in males was 9.73 （4.01‒23.70） RU‧mL-1， lower than 17.76 （7.07‒49.23） RU‧mL-1 in females （P<0.05）. The median concentration in the residents vaccinated with BBIBP-CorV （Sinopharm） was 6.53 （0.97‒13.69） RU‧mL-1， which was lower than that in those vaccinated with CoronaVac （Sinovac） that was 17.29 （8.54‒43.73） RU‧mL-1 （P<0.05）. The median concentration in those with BBIBP-CorV was also lower than 12 （5.45‒40.06） RU‧mL-1 in those with heterologous booster vaccine （P<0.05）. The median concentration was 9.73 （3.83‒23.63） RU‧mL-1 in the residents with an interval of more than 6 months from the second dose， which was lower than 14.66 （6.36‒35.98） RU‧mL-1 in those with an interval of 3‒6 months （P<0.05）. Moreover， immune effect was better in females （χ²=16.464， P<0.05）， 18‒45 years （χ²=7.158， P<0.05）， and those vaccinated with CornaVac （χ²=49.637， P<0.05）， while decreased in those with an interval of more than 6 months from the second dose （χ²=8.447， P<0.05）.ConclusionGender， age， and type of vaccine may affect the effect of immunization. The COVID-19 vaccination shows an acceptable immunogenicity in adults； however， it declines in 6 months after vaccination. It warrants strengthening the booster vaccination to maintain the immune response. |
| first_indexed | 2024-04-10T19:12:29Z |
| format | Article |
| id | doaj.art-acfd205a630a4bf984f1d07c09e1c1f5 |
| institution | Directory Open Access Journal |
| issn | 1004-9231 |
| language | zho |
| last_indexed | 2024-04-10T19:12:29Z |
| publishDate | 2022-11-01 |
| publisher | Shanghai Preventive Medicine Association |
| record_format | Article |
| series | Shanghai yufang yixue |
| spelling | doaj.art-acfd205a630a4bf984f1d07c09e1c1f52023-01-30T10:54:17ZzhoShanghai Preventive Medicine AssociationShanghai yufang yixue1004-92312022-11-0134111118112210.19428/j.cnki.sjpm.2022.221051004-9231（2022）11-1118-05Serological evaluation of immune effect of inactivated COVID-19 vaccine in adult population in Deqing County， Huzhou City， Zhejiang ProvinceMAO Chuanwu0CHEN Yingfeng1ZHANG Li2XIE Yuyang3DONG Xiaolian4JIANG Lufang5JIANG Qingwu6School of Public Health, Fudan University, Shanghai 200032, ChinaDeqing County Center for Disease Control and Prevention, Huzhou Zhejiang 313200, ChinaSchool of Public Health, Fudan University, Shanghai 200032, ChinaDeqing County Center for Disease Control and Prevention, Huzhou Zhejiang 313200, ChinaDeqing County Center for Disease Control and Prevention, Huzhou Zhejiang 313200, ChinaSchool of Public Health, Fudan University, Shanghai 200032, ChinaSchool of Public Health, Fudan University, Shanghai 200032, ChinaObjectiveTo investigate the specific anti-SARS-CoV-2 antibody in adults and above after initial vaccination with inactivated COVID-19 vaccine， and determine the influencing factors.MethodsIn this study， residents aged 18 and above who had completed two doses of inactivated COVID-19 vaccine in Deqing County， Huzhou City， Zhejiang Province were included. Information such as gender， age， type of vaccine and vaccination time were collected， and serum specimens were sampled. Anti-SARS-CoV-2 receptor binding domain （RBD） antibody was quantitatively examined by enzyma-linked immunosorbent assay （ELISA） and influencing factors were determined.ResultsThe median concentration of anti-SARS-CoV-2 IgG antibody in the residents vaccinated with an inactivated booster vaccine was higher than that in those vaccinated with only two doses of COVID-19 vaccine or single dose （P<0.05）. The median concentration of IgG antibody in males was 9.73 （4.01‒23.70） RU‧mL-1， lower than 17.76 （7.07‒49.23） RU‧mL-1 in females （P<0.05）. The median concentration in the residents vaccinated with BBIBP-CorV （Sinopharm） was 6.53 （0.97‒13.69） RU‧mL-1， which was lower than that in those vaccinated with CoronaVac （Sinovac） that was 17.29 （8.54‒43.73） RU‧mL-1 （P<0.05）. The median concentration in those with BBIBP-CorV was also lower than 12 （5.45‒40.06） RU‧mL-1 in those with heterologous booster vaccine （P<0.05）. The median concentration was 9.73 （3.83‒23.63） RU‧mL-1 in the residents with an interval of more than 6 months from the second dose， which was lower than 14.66 （6.36‒35.98） RU‧mL-1 in those with an interval of 3‒6 months （P<0.05）. Moreover， immune effect was better in females （χ²=16.464， P<0.05）， 18‒45 years （χ²=7.158， P<0.05）， and those vaccinated with CornaVac （χ²=49.637， P<0.05）， while decreased in those with an interval of more than 6 months from the second dose （χ²=8.447， P<0.05）.ConclusionGender， age， and type of vaccine may affect the effect of immunization. The COVID-19 vaccination shows an acceptable immunogenicity in adults； however， it declines in 6 months after vaccination. It warrants strengthening the booster vaccination to maintain the immune response.http://www.sjpm.org.cn/article/doi/10.19428/j.cnki.sjpm.2022.22105covid-19 vaccineanti-sars-cov-2 receptor binding domain igg antibodyimmune effectserological evaluation |
| spellingShingle | MAO Chuanwu CHEN Yingfeng ZHANG Li XIE Yuyang DONG Xiaolian JIANG Lufang JIANG Qingwu Serological evaluation of immune effect of inactivated COVID-19 vaccine in adult population in Deqing County， Huzhou City， Zhejiang Province Shanghai yufang yixue covid-19 vaccine anti-sars-cov-2 receptor binding domain igg antibody immune effect serological evaluation |
| title | Serological evaluation of immune effect of inactivated COVID-19 vaccine in adult population in Deqing County， Huzhou City， Zhejiang Province |
| title_full | Serological evaluation of immune effect of inactivated COVID-19 vaccine in adult population in Deqing County， Huzhou City， Zhejiang Province |
| title_fullStr | Serological evaluation of immune effect of inactivated COVID-19 vaccine in adult population in Deqing County， Huzhou City， Zhejiang Province |
| title_full_unstemmed | Serological evaluation of immune effect of inactivated COVID-19 vaccine in adult population in Deqing County， Huzhou City， Zhejiang Province |
| title_short | Serological evaluation of immune effect of inactivated COVID-19 vaccine in adult population in Deqing County， Huzhou City， Zhejiang Province |
| title_sort | serological evaluation of immune effect of inactivated covid 19 vaccine in adult population in deqing county huzhou city zhejiang province |
| topic | covid-19 vaccine anti-sars-cov-2 receptor binding domain igg antibody immune effect serological evaluation |
| url | http://www.sjpm.org.cn/article/doi/10.19428/j.cnki.sjpm.2022.22105 |
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