POSSIBLE WAYS OF PHARMACOLOGICAL CORRECTION OF ISCHEMIC DAMAGE TO THE LIVER WITH THE AGONIST OF PERIPHERAL IMIDAZOLINE RECEPTORS C7070
Introduction: We glad to introduce several variants of pharmacological correction of ischemic hepatic injury by imidazoline I2 receptor agonistС7070. Materials and methods: The experiment was carried out on 70 rats of both sexes, divided into 7 groups (n = 10): an intact group; Pseudo-operated anim...
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| Format: | Article |
| Language: | English |
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Belgorod National Research University
2017-09-01
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| Series: | Research Results in Pharmacology |
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| Online Access: | https://rrpharmacology.pensoft.net/article/31092/download/pdf/ |
| _version_ | 1797430625437745152 |
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| author | Anton Dovgan Zhanna Urozhevskaya Anatolii Khavanskii |
| author_facet | Anton Dovgan Zhanna Urozhevskaya Anatolii Khavanskii |
| author_sort | Anton Dovgan |
| collection | DOAJ |
| description | Introduction: We glad to introduce several variants of pharmacological correction of ischemic hepatic injury by imidazoline I2 receptor agonistС7070.
Materials and methods: The experiment was carried out on 70 rats of both sexes, divided into 7 groups (n = 10): an intact group; Pseudo-operated animals (autopsy of the abdominal wall without ligation of the liver vessels); Ischemia / reperfusion group without drug correction; Animals undergoing ischemia / liver reperfusion + Metformin (50 mg / kg); Animals undergoing ischemia / liver reperfusion + Moxonidine (1 μg / kg); Animals undergoing ischemia / liver reperfusion + C7070 (1 mg / kg). For the evaluation, the coefficients calculated from the level of hepatic transaminases (ALT, AST), as well as morphometric ratios of the area of necrosis and deep ischemia of the liver, were used for the evaluation according to the histological examination.
Results and discussion: The indicated agonists of peripheral imidazoline I2receptors (C7070) significantly reducesischemically-reperfusion injury of the liver, in comparison with the preparations of moxonidine and metformine. Indirect sign of imidazoline activating mechanism of C7070 is decreasing of the hepatoprotective effect of C7070 by the preliminary administration of imidazoline receptor blocker BU-224. The coefficients for ALT / AST for C7070, moxonidine and metformin were 72.8 / 62.13, respectively; 44.99 / 34.20 and 36.88 / 21.02. The coefficients of the morphological hepatoprotective activity of the preparations were: С7070 – 82.61, moxonidine – 72.33, metformin – 38.96.
Conclusions: The imidazoline receptor agonists significantly and significantly reduce the functional and morphological manifestations of liver ischemia / reperfusion. |
| first_indexed | 2024-03-09T09:31:11Z |
| format | Article |
| id | doaj.art-acff045dc2fc4deabd9a022e3d90ffdd |
| institution | Directory Open Access Journal |
| issn | 2658-381X |
| language | English |
| last_indexed | 2024-03-09T09:31:11Z |
| publishDate | 2017-09-01 |
| publisher | Belgorod National Research University |
| record_format | Article |
| series | Research Results in Pharmacology |
| spelling | doaj.art-acff045dc2fc4deabd9a022e3d90ffdd2023-12-02T03:54:18ZengBelgorod National Research UniversityResearch Results in Pharmacology2658-381X2017-09-01333810.18413/2313-8971-2017-3-3-3-831092POSSIBLE WAYS OF PHARMACOLOGICAL CORRECTION OF ISCHEMIC DAMAGE TO THE LIVER WITH THE AGONIST OF PERIPHERAL IMIDAZOLINE RECEPTORS C7070Anton DovganZhanna UrozhevskayaAnatolii KhavanskiiIntroduction: We glad to introduce several variants of pharmacological correction of ischemic hepatic injury by imidazoline I2 receptor agonistС7070. Materials and methods: The experiment was carried out on 70 rats of both sexes, divided into 7 groups (n = 10): an intact group; Pseudo-operated animals (autopsy of the abdominal wall without ligation of the liver vessels); Ischemia / reperfusion group without drug correction; Animals undergoing ischemia / liver reperfusion + Metformin (50 mg / kg); Animals undergoing ischemia / liver reperfusion + Moxonidine (1 μg / kg); Animals undergoing ischemia / liver reperfusion + C7070 (1 mg / kg). For the evaluation, the coefficients calculated from the level of hepatic transaminases (ALT, AST), as well as morphometric ratios of the area of necrosis and deep ischemia of the liver, were used for the evaluation according to the histological examination. Results and discussion: The indicated agonists of peripheral imidazoline I2receptors (C7070) significantly reducesischemically-reperfusion injury of the liver, in comparison with the preparations of moxonidine and metformine. Indirect sign of imidazoline activating mechanism of C7070 is decreasing of the hepatoprotective effect of C7070 by the preliminary administration of imidazoline receptor blocker BU-224. The coefficients for ALT / AST for C7070, moxonidine and metformin were 72.8 / 62.13, respectively; 44.99 / 34.20 and 36.88 / 21.02. The coefficients of the morphological hepatoprotective activity of the preparations were: С7070 – 82.61, moxonidine – 72.33, metformin – 38.96. Conclusions: The imidazoline receptor agonists significantly and significantly reduce the functional and morphological manifestations of liver ischemia / reperfusion.https://rrpharmacology.pensoft.net/article/31092/download/pdf/Liver ischemialiver reperfusiondiabetes mellit |
| spellingShingle | Anton Dovgan Zhanna Urozhevskaya Anatolii Khavanskii POSSIBLE WAYS OF PHARMACOLOGICAL CORRECTION OF ISCHEMIC DAMAGE TO THE LIVER WITH THE AGONIST OF PERIPHERAL IMIDAZOLINE RECEPTORS C7070 Research Results in Pharmacology Liver ischemia liver reperfusion diabetes mellit |
| title | POSSIBLE WAYS OF PHARMACOLOGICAL CORRECTION OF ISCHEMIC DAMAGE TO THE LIVER WITH THE AGONIST OF PERIPHERAL IMIDAZOLINE RECEPTORS C7070 |
| title_full | POSSIBLE WAYS OF PHARMACOLOGICAL CORRECTION OF ISCHEMIC DAMAGE TO THE LIVER WITH THE AGONIST OF PERIPHERAL IMIDAZOLINE RECEPTORS C7070 |
| title_fullStr | POSSIBLE WAYS OF PHARMACOLOGICAL CORRECTION OF ISCHEMIC DAMAGE TO THE LIVER WITH THE AGONIST OF PERIPHERAL IMIDAZOLINE RECEPTORS C7070 |
| title_full_unstemmed | POSSIBLE WAYS OF PHARMACOLOGICAL CORRECTION OF ISCHEMIC DAMAGE TO THE LIVER WITH THE AGONIST OF PERIPHERAL IMIDAZOLINE RECEPTORS C7070 |
| title_short | POSSIBLE WAYS OF PHARMACOLOGICAL CORRECTION OF ISCHEMIC DAMAGE TO THE LIVER WITH THE AGONIST OF PERIPHERAL IMIDAZOLINE RECEPTORS C7070 |
| title_sort | possible ways of pharmacological correction of ischemic damage to the liver with the agonist of peripheral imidazoline receptors c7070 |
| topic | Liver ischemia liver reperfusion diabetes mellit |
| url | https://rrpharmacology.pensoft.net/article/31092/download/pdf/ |
| work_keys_str_mv | AT antondovgan possiblewaysofpharmacologicalcorrectionofischemicdamagetotheliverwiththeagonistofperipheralimidazolinereceptorsc7070 AT zhannaurozhevskaya possiblewaysofpharmacologicalcorrectionofischemicdamagetotheliverwiththeagonistofperipheralimidazolinereceptorsc7070 AT anatoliikhavanskii possiblewaysofpharmacologicalcorrectionofischemicdamagetotheliverwiththeagonistofperipheralimidazolinereceptorsc7070 |