The Predictive Role of MMP-2, MMP-9, TIMP-1 and TIMP-2 Serum Levels in the Complete Response of the Tumor to Chemotherapy in Breast Cancer Patients
Objective We investigated the serum levels of MMPs and TIMPs in breast cancer (BC) patients to predict the response rate to/after treatment with or without neoadjuvant chemotherapy. BC is the most common cancer in women and MMPs are responsible for the breakdown of ECM proteins during organogenesis...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-07-01
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| Series: | Journal of Investigative Surgery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/08941939.2022.2080308 |
| _version_ | 1827817158447464448 |
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| author | Kayhan Ozdemir Ismail Zengin Gamze Guney Eskiler Havva Belma Kocer Asuman Deveci Ozkan Tayfur Demiray Elif Ozozen Sahin |
| author_facet | Kayhan Ozdemir Ismail Zengin Gamze Guney Eskiler Havva Belma Kocer Asuman Deveci Ozkan Tayfur Demiray Elif Ozozen Sahin |
| author_sort | Kayhan Ozdemir |
| collection | DOAJ |
| description | Objective We investigated the serum levels of MMPs and TIMPs in breast cancer (BC) patients to predict the response rate to/after treatment with or without neoadjuvant chemotherapy. BC is the most common cancer in women and MMPs are responsible for the breakdown of ECM proteins during organogenesis and TIMPs are restricted the ECM destruction by MMPs. However, the predictive role of MMPs and TIMPs in the treatment response of BC patients has not identified. Methods This study consisted of 96 BC patients (34 neoadjuvant treatment and 62 surgically treated) and 35 healthy individuals. ELISA was used to determine the level of MMP-2, MMP-9, TIMP-1, and TIMP-2 from serum samples of BC patients. Results The mean levels of MMP-9 and TIMP-2 were significantly increased in all BC patients at diagnosis and after chemotherapy, but MMP-2 was considerably lower at diagnosis. There was only a significant difference in the TIMP-1 levels after chemotherapy as well as HER2 and ER status in the neoadjuvant and surgically treated group. Additionally, MMP-2 and MMP-9 serum levels negatively correlated with tumor size and metastatic lymph nodes in BC patients after chemotherapy. Conclusions BC patients with high levels of MMP-9 and TIMP-2 can be used to predict the stage of the tumor and CR to chemotherapy and higher TIMP-1 serum level after chemotherapy could be related to better response to chemotherapy. |
| first_indexed | 2024-03-12T00:30:26Z |
| format | Article |
| id | doaj.art-acffd5bd919040e88aab3d11ffad4f7b |
| institution | Directory Open Access Journal |
| issn | 0894-1939 1521-0553 |
| language | English |
| last_indexed | 2024-03-12T00:30:26Z |
| publishDate | 2022-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Investigative Surgery |
| spelling | doaj.art-acffd5bd919040e88aab3d11ffad4f7b2023-09-15T10:21:30ZengTaylor & Francis GroupJournal of Investigative Surgery0894-19391521-05532022-07-013571544155010.1080/08941939.2022.20803082080308The Predictive Role of MMP-2, MMP-9, TIMP-1 and TIMP-2 Serum Levels in the Complete Response of the Tumor to Chemotherapy in Breast Cancer PatientsKayhan Ozdemir0Ismail Zengin1Gamze Guney Eskiler2Havva Belma Kocer3Asuman Deveci Ozkan4Tayfur Demiray5Elif Ozozen Sahin6Department of General Surgery, Sakarya University Research and Educational HospitalDepartment of General Surgery, Sakarya University Research and Educational HospitalDepartment of Medical Biology, Faculty of Medicine, Sakarya UniversityDepartment of General Surgery, Faculty of Medicine, Sakarya UniversityDepartment of Medical Biology, Faculty of Medicine, Sakarya UniversityDepartment of Microbiology and Immunology, Research and Educational Hospital, Sakarya UniversityDepartment of Microbiology and Immunology, Research and Educational Hospital, Sakarya UniversityObjective We investigated the serum levels of MMPs and TIMPs in breast cancer (BC) patients to predict the response rate to/after treatment with or without neoadjuvant chemotherapy. BC is the most common cancer in women and MMPs are responsible for the breakdown of ECM proteins during organogenesis and TIMPs are restricted the ECM destruction by MMPs. However, the predictive role of MMPs and TIMPs in the treatment response of BC patients has not identified. Methods This study consisted of 96 BC patients (34 neoadjuvant treatment and 62 surgically treated) and 35 healthy individuals. ELISA was used to determine the level of MMP-2, MMP-9, TIMP-1, and TIMP-2 from serum samples of BC patients. Results The mean levels of MMP-9 and TIMP-2 were significantly increased in all BC patients at diagnosis and after chemotherapy, but MMP-2 was considerably lower at diagnosis. There was only a significant difference in the TIMP-1 levels after chemotherapy as well as HER2 and ER status in the neoadjuvant and surgically treated group. Additionally, MMP-2 and MMP-9 serum levels negatively correlated with tumor size and metastatic lymph nodes in BC patients after chemotherapy. Conclusions BC patients with high levels of MMP-9 and TIMP-2 can be used to predict the stage of the tumor and CR to chemotherapy and higher TIMP-1 serum level after chemotherapy could be related to better response to chemotherapy.http://dx.doi.org/10.1080/08941939.2022.2080308breast cancercomplete responsemmpstimps |
| spellingShingle | Kayhan Ozdemir Ismail Zengin Gamze Guney Eskiler Havva Belma Kocer Asuman Deveci Ozkan Tayfur Demiray Elif Ozozen Sahin The Predictive Role of MMP-2, MMP-9, TIMP-1 and TIMP-2 Serum Levels in the Complete Response of the Tumor to Chemotherapy in Breast Cancer Patients Journal of Investigative Surgery breast cancer complete response mmps timps |
| title | The Predictive Role of MMP-2, MMP-9, TIMP-1 and TIMP-2 Serum Levels in the Complete Response of the Tumor to Chemotherapy in Breast Cancer Patients |
| title_full | The Predictive Role of MMP-2, MMP-9, TIMP-1 and TIMP-2 Serum Levels in the Complete Response of the Tumor to Chemotherapy in Breast Cancer Patients |
| title_fullStr | The Predictive Role of MMP-2, MMP-9, TIMP-1 and TIMP-2 Serum Levels in the Complete Response of the Tumor to Chemotherapy in Breast Cancer Patients |
| title_full_unstemmed | The Predictive Role of MMP-2, MMP-9, TIMP-1 and TIMP-2 Serum Levels in the Complete Response of the Tumor to Chemotherapy in Breast Cancer Patients |
| title_short | The Predictive Role of MMP-2, MMP-9, TIMP-1 and TIMP-2 Serum Levels in the Complete Response of the Tumor to Chemotherapy in Breast Cancer Patients |
| title_sort | predictive role of mmp 2 mmp 9 timp 1 and timp 2 serum levels in the complete response of the tumor to chemotherapy in breast cancer patients |
| topic | breast cancer complete response mmps timps |
| url | http://dx.doi.org/10.1080/08941939.2022.2080308 |
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