Non-Coding RNAs: Strategy for Viruses’ Offensive
The awareness of viruses as a constant threat for human public health is a matter of fact and in this resides the need of understanding the mechanisms they use to trick the host. Viral non-coding RNAs are gaining much value and interest for the potential impact played in host gene regulation, acting...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Non-Coding RNA |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2311-553X/6/3/38 |
| _version_ | 1827706537911517184 |
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| author | Alessia Gallo Matteo Bulati Vitale Miceli Nicola Amodio Pier Giulio Conaldi |
| author_facet | Alessia Gallo Matteo Bulati Vitale Miceli Nicola Amodio Pier Giulio Conaldi |
| author_sort | Alessia Gallo |
| collection | DOAJ |
| description | The awareness of viruses as a constant threat for human public health is a matter of fact and in this resides the need of understanding the mechanisms they use to trick the host. Viral non-coding RNAs are gaining much value and interest for the potential impact played in host gene regulation, acting as fine tuners of host cellular defense mechanisms. The implicit importance of v-ncRNAs resides first in the limited genomes size of viruses carrying only strictly necessary genomic sequences. The other crucial and appealing characteristic of v-ncRNAs is the non-immunogenicity, making them the perfect expedient to be used in the never-ending virus-host war. In this review, we wish to examine how DNA and RNA viruses have evolved a common strategy and which the crucial host pathways are targeted through v-ncRNAs in order to grant and facilitate their life cycle. |
| first_indexed | 2024-03-10T16:25:41Z |
| format | Article |
| id | doaj.art-ad008f70b34244dc8e1f90c0533e1395 |
| institution | Directory Open Access Journal |
| issn | 2311-553X |
| language | English |
| last_indexed | 2024-03-10T16:25:41Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Non-Coding RNA |
| spelling | doaj.art-ad008f70b34244dc8e1f90c0533e13952023-11-20T13:15:15ZengMDPI AGNon-Coding RNA2311-553X2020-09-01633810.3390/ncrna6030038Non-Coding RNAs: Strategy for Viruses’ OffensiveAlessia Gallo0Matteo Bulati1Vitale Miceli2Nicola Amodio3Pier Giulio Conaldi4Department of Research, IRCCS ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione), Via E.Tricomi 5, 90127 Palermo, ItalyDepartment of Research, IRCCS ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione), Via E.Tricomi 5, 90127 Palermo, ItalyDepartment of Research, IRCCS ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione), Via E.Tricomi 5, 90127 Palermo, ItalyDepartment of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, 88100 Catanzaro, ItalyDepartment of Research, IRCCS ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione), Via E.Tricomi 5, 90127 Palermo, ItalyThe awareness of viruses as a constant threat for human public health is a matter of fact and in this resides the need of understanding the mechanisms they use to trick the host. Viral non-coding RNAs are gaining much value and interest for the potential impact played in host gene regulation, acting as fine tuners of host cellular defense mechanisms. The implicit importance of v-ncRNAs resides first in the limited genomes size of viruses carrying only strictly necessary genomic sequences. The other crucial and appealing characteristic of v-ncRNAs is the non-immunogenicity, making them the perfect expedient to be used in the never-ending virus-host war. In this review, we wish to examine how DNA and RNA viruses have evolved a common strategy and which the crucial host pathways are targeted through v-ncRNAs in order to grant and facilitate their life cycle.https://www.mdpi.com/2311-553X/6/3/38immune evasionmiRNA mimicryviral circRNAviral non-coding RNA |
| spellingShingle | Alessia Gallo Matteo Bulati Vitale Miceli Nicola Amodio Pier Giulio Conaldi Non-Coding RNAs: Strategy for Viruses’ Offensive Non-Coding RNA immune evasion miRNA mimicry viral circRNA viral non-coding RNA |
| title | Non-Coding RNAs: Strategy for Viruses’ Offensive |
| title_full | Non-Coding RNAs: Strategy for Viruses’ Offensive |
| title_fullStr | Non-Coding RNAs: Strategy for Viruses’ Offensive |
| title_full_unstemmed | Non-Coding RNAs: Strategy for Viruses’ Offensive |
| title_short | Non-Coding RNAs: Strategy for Viruses’ Offensive |
| title_sort | non coding rnas strategy for viruses offensive |
| topic | immune evasion miRNA mimicry viral circRNA viral non-coding RNA |
| url | https://www.mdpi.com/2311-553X/6/3/38 |
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