The Use of Prophylaxis Antibiotics to Prevent Acute Pancreatitis Complications: Meta-Analysis of Clinical Trials
Background: Acute pancreatitis (AP) is an inflammation of the pancreas, a serious emergency with no definitive treatment. It may progress to infected necrosis, non-pancreatitis infection, also death that may occur within the first 1 to 2 weeks. The use of prophylactic antibiotics in AP to prevent co...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Interna Publishing
2022-01-01
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| Series: | The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy |
| Subjects: | |
| Online Access: | https://www.ina-jghe.com/index.php/jghe/article/view/813 |
| _version_ | 1797810511837921280 |
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| author | Dwita Nitoya Esterini Kirsten Putriani Hartman Joue Abraham Trixie Yessi Setianegari Kurniyanto Kurniyanto |
| author_facet | Dwita Nitoya Esterini Kirsten Putriani Hartman Joue Abraham Trixie Yessi Setianegari Kurniyanto Kurniyanto |
| author_sort | Dwita Nitoya Esterini |
| collection | DOAJ |
| description | Background: Acute pancreatitis (AP) is an inflammation of the pancreas, a serious emergency with no definitive treatment. It may progress to infected necrosis, non-pancreatitis infection, also death that may occur within the first 1 to 2 weeks. The use of prophylactic antibiotics in AP to prevent complications remains a controversy. The objective of this meta-analysis is to assess the benefit of prophylaxis antibiotics administration to prevent the complication.
Method: Trials were identified by searching the medical database. Literature range is within the year 1975 to 2021. Review Manager 5.4.1 was used to analyse data extraction and risk of bias of included studies were elaborated. Risk ratio (RR) was calculated with 95% confidence interval (CI). P 0.05 was considered significant.
Results: Twenty trials with a total of 1.287 patients of AP were analysed; 646 patients treated with antibiotic prophylaxis and 641 patients treated with placebo. Prophylaxis antibiotics were found to have significant difference between the two groups. The administration of prophylaxis antibiotics lower the risk of non-pancreatic infections (RR = 0.77; 95% CI: 0.62–0.95; p 0.05) and infected pancreatic necrosis (RR = 0.74; 95% CI: 0.58-0.94; p 0.05). Meanwhile, prophylaxis antibiotics were found to be insignificant to lower the risk of mortality (RR = 0.75; 95% CI: 0.54-1.03; p 0.05).
Conclusion: Prophylaxis antibiotics lower the risk of non-pancreatic infections and infected pancreatic necrosis, but did not lower the risk of mortality. |
| first_indexed | 2024-03-13T07:10:01Z |
| format | Article |
| id | doaj.art-ad0201509f464844a7b54802b01b0ac1 |
| institution | Directory Open Access Journal |
| issn | 1411-4801 2302-8181 |
| language | English |
| last_indexed | 2024-03-13T07:10:01Z |
| publishDate | 2022-01-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy |
| spelling | doaj.art-ad0201509f464844a7b54802b01b0ac12023-06-06T04:42:34ZengInterna PublishingThe Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy1411-48012302-81812022-01-0122319620210.24871/2232021196-202758The Use of Prophylaxis Antibiotics to Prevent Acute Pancreatitis Complications: Meta-Analysis of Clinical TrialsDwita Nitoya Esterini0Kirsten Putriani Hartman1Joue Abraham Trixie2Yessi Setianegari3Kurniyanto Kurniyanto4Faculty of Medicine, Christian University of Indonesia, JakartaFaculty of Medicine, Christian University of Indonesia, JakartaFaculty of Medicine, Christian University of Indonesia, JakartaFaculty of Medicine, Christian University of Indonesia, JakartaDepartment of Internal Medicine, Faculty of Medicine, Christian University of Indonesia, JakartaBackground: Acute pancreatitis (AP) is an inflammation of the pancreas, a serious emergency with no definitive treatment. It may progress to infected necrosis, non-pancreatitis infection, also death that may occur within the first 1 to 2 weeks. The use of prophylactic antibiotics in AP to prevent complications remains a controversy. The objective of this meta-analysis is to assess the benefit of prophylaxis antibiotics administration to prevent the complication. Method: Trials were identified by searching the medical database. Literature range is within the year 1975 to 2021. Review Manager 5.4.1 was used to analyse data extraction and risk of bias of included studies were elaborated. Risk ratio (RR) was calculated with 95% confidence interval (CI). P 0.05 was considered significant. Results: Twenty trials with a total of 1.287 patients of AP were analysed; 646 patients treated with antibiotic prophylaxis and 641 patients treated with placebo. Prophylaxis antibiotics were found to have significant difference between the two groups. The administration of prophylaxis antibiotics lower the risk of non-pancreatic infections (RR = 0.77; 95% CI: 0.62–0.95; p 0.05) and infected pancreatic necrosis (RR = 0.74; 95% CI: 0.58-0.94; p 0.05). Meanwhile, prophylaxis antibiotics were found to be insignificant to lower the risk of mortality (RR = 0.75; 95% CI: 0.54-1.03; p 0.05). Conclusion: Prophylaxis antibiotics lower the risk of non-pancreatic infections and infected pancreatic necrosis, but did not lower the risk of mortality.https://www.ina-jghe.com/index.php/jghe/article/view/813acute pancreatitisantibiotic prophylaxisclinical trialmortality |
| spellingShingle | Dwita Nitoya Esterini Kirsten Putriani Hartman Joue Abraham Trixie Yessi Setianegari Kurniyanto Kurniyanto The Use of Prophylaxis Antibiotics to Prevent Acute Pancreatitis Complications: Meta-Analysis of Clinical Trials The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy acute pancreatitis antibiotic prophylaxis clinical trial mortality |
| title | The Use of Prophylaxis Antibiotics to Prevent Acute Pancreatitis Complications: Meta-Analysis of Clinical Trials |
| title_full | The Use of Prophylaxis Antibiotics to Prevent Acute Pancreatitis Complications: Meta-Analysis of Clinical Trials |
| title_fullStr | The Use of Prophylaxis Antibiotics to Prevent Acute Pancreatitis Complications: Meta-Analysis of Clinical Trials |
| title_full_unstemmed | The Use of Prophylaxis Antibiotics to Prevent Acute Pancreatitis Complications: Meta-Analysis of Clinical Trials |
| title_short | The Use of Prophylaxis Antibiotics to Prevent Acute Pancreatitis Complications: Meta-Analysis of Clinical Trials |
| title_sort | use of prophylaxis antibiotics to prevent acute pancreatitis complications meta analysis of clinical trials |
| topic | acute pancreatitis antibiotic prophylaxis clinical trial mortality |
| url | https://www.ina-jghe.com/index.php/jghe/article/view/813 |
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