Inhibition of NKCC1 Ameliorates Anxiety and Autistic Behaviors Induced by Maternal Immune Activation in Mice

Inhibition of NKCC1 Ameliorates Anxiety and Autistic Behaviors Induced by Maternal Immune Activation in Mice

Autism spectrum disorder (ASD) is thought to result from susceptibility genotypes and environmental risk factors. The offspring of women who experience pregnancy infection have an increased risk for autism. Maternal immune activation (MIA) in pregnant animals produces offspring with autistic behavio...

Full description

Bibliographic Details
Main Authors:	Hai-Long Zhang, Shufen Hu, Shu-Ting Qu, Meng-Dan Lv, Jun-Jun Wang, Xin-Ting Liu, Jia-He Yao, Yi-Yan Ding, Guang-Yin Xu
Format:	Article
Language:	English
Published:	MDPI AG 2024-02-01
Series:	Current Issues in Molecular Biology
Subjects:	autism social behavior maternal immune activation poly(I:C) NKCC1
Online Access:	https://www.mdpi.com/1467-3045/46/3/121

Similar Items

Upregulation of Spinal ASIC1 and NKCC1 Expression Contributes to Chronic Visceral Pain in Rats
by: Yong-Chang Li, et al.
Published: (2021-01-01)

Role of NKCC1 and KCC2 in Epilepsy: From Expression to Function
by: Ru Liu, et al.
Published: (2020-01-01)

Poly(I:C)-induced maternal immune activation causes elevated self-grooming in male rat offspring: Involvement of abnormal postpartum static nursing in dam
by: Xing-Yu Lan, et al.
Published: (2023-03-01)

NKCC1 Regulates Migration Ability of Glioblastoma Cells by Modulation of Actin Dynamics and Interacting with Cofilin
by: Paula Schiapparelli, et al.
Published: (2017-07-01)

Differential Effects of STCH and Stress-Inducible Hsp70 on the Stability and Maturation of NKCC2
by: Dalal Bakhos-Douaihy, et al.
Published: (2021-02-01)

NFAT5 and HIF-1α Coordinate to Regulate NKCC1 Expression in Hippocampal Neurons After Hypoxia-Ischemia
by: Xing-Liang Yang, et al.
Published: (2019-12-01)

Vitexin reduces epilepsy after hypoxic ischemia in the neonatal brain via inhibition of NKCC1
by: Wen-di Luo, et al.
Published: (2018-06-01)

Interleukin 15 modulates the effects of poly I:C maternal immune activation on offspring behaviour
by: Faraj L. Haddad, et al.
Published: (2022-08-01)

Decreased Immunoreactivities of the Chloride Transporters, KCC2 and NKCC1, in the Lateral Superior Olive Neurons of Kanamycin-treated Rats
by: Myung-Whan Suh, et al.
Published: (2012-09-01)

The role of KCC2 and NKCC1 in spinal cord injury: From physiology to pathology
by: Zuliyaer Talifu, et al.
Published: (2022-12-01)

Beta-Amyloid (Aβ<sub>1-42</sub>) Increases the Expression of NKCC1 in the Mouse Hippocampus
by: Patricia Lam, et al.
Published: (2022-04-01)

Seizures regulate the cation-Cl− cotransporter NKCC1 in a hamster model of epilepsy: implications for GABA neurotransmission
by: Juan-Manuel Bonet-Fernández, et al.
Published: (2023-06-01)

Cation-Chloride Cotransporters KCC2 and NKCC1 as Therapeutic Targets in Neurological and Neuropsychiatric Disorders
by: Patricia Lam, et al.
Published: (2023-01-01)

NKCC1-deficiency results in abnormal proliferation of neural progenitor cells of the lateral ganglionic eminence
by: Ana Cathia Magalhães, et al.
Published: (2016-08-01)

CSF Secretion Is Not Altered by NKCC1 Nor TRPV4 Antagonism in Healthy Rats
by: Steven W. Bothwell, et al.
Published: (2021-08-01)

Age-appropriate potassium clearance from perinatal cerebrospinal fluid depends on choroid plexus NKCC1
by: Ryann M. Fame, et al.
Published: (2023-06-01)

NKCC1, an Elusive Molecular Target in Brain Development: Making Sense of the Existing Data
by: Mari A. Virtanen, et al.
Published: (2020-12-01)

NKCC1 Deficiency in Forming Hippocampal Circuits Triggers Neurodevelopmental Disorder: Role of BDNF-TrkB Signalling
by: Jacek Szymanski, et al.
Published: (2022-04-01)

A commentary on Maternal immune activation evoked by polyinosinic:polycytidylic acid does not evoke microglial cell activation in the embryo
by: Hans-Gert eBernstein, et al.
Published: (2016-02-01)

Investigating behavioral phenotypes related to autism spectrum disorder in a gene-environment interaction model of Cntnap2 deficiency and Poly I:C maternal immune activation
by: Faraj L. Haddad, et al.
Published: (2023-03-01)

Ketogenic Diet Provided During Three Months Increases KCC2 Expression but Not NKCC1 in the Rat Dentate Gyrus
by: Leticia Granados-Rojas, et al.
Published: (2020-07-01)

Golgi Alpha1,2-Mannosidase IA Promotes Efficient Endoplasmic Reticulum-Associated Degradation of NKCC2
by: Sylvie Demaretz, et al.
Published: (2021-12-01)

NKCC1 involvement in the epithelial-to-mesenchymal transition is a prognostic biomarker in gliomas
by: Huaiyu Sun, et al.
Published: (2020-03-01)

Age-related changes in neuroinflammation and prepulse inhibition in offspring of rats treated with Poly I:C in early gestation
by: Shuang Ding, et al.
Published: (2019-03-01)

Maternal Immune Activation Affects Hippocampal Excitatory and Inhibitory Synaptic Transmission in Offspring From an Early Developmental Period to Adulthood
by: Keiju Nakagawa, et al.
Published: (2020-08-01)

In silico identification of potential inhibitors with higher potency than bumetanide targeting NKCC1: An important ion co-transporter to treat neurological disorders
by: Arpita Singha Roy, et al.
Published: (2021-01-01)

Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1 cotransporter in the choroid plexus: an evidence of genetic risk for hydrocephalus in an experimental study
by: Hanbing Xu, et al.
Published: (2022-06-01)

Inhibition of the NKCC1/NF-κB Signaling Pathway Decreases Inflammation and Improves Brain Edema and Nerve Cell Apoptosis in an SBI Rat Model
by: Yating Gong, et al.
Published: (2021-03-01)

NLRP3 inflammasome-mediated choroid plexus hypersecretion contributes to hydrocephalus after intraventricular hemorrhage via phosphorylated NKCC1 channels
by: Zhaoqi Zhang, et al.
Published: (2022-06-01)

Lack of NHE6 and Inhibition of NKCC1 Associated With Increased Permeability in Blood Labyrinth Barrier-Derived Endothelial Cell Layer
by: Marijana Sekulic-Jablanovic, et al.
Published: (2022-04-01)

A comprehensive approach to modeling maternal immune activation in rodents
by: Morgan C. Bucknor, et al.
Published: (2022-12-01)

Pretreatment with AQP4 and NKCC1 Inhibitors Concurrently Attenuated Spinal Cord Edema and Tissue Damage after Spinal Cord Injury in Rats
by: Xiaodong Yan, et al.
Published: (2018-01-01)

Maternal restraint stress delays maturation of cation-chloride cotransporters and GABAA receptor subunits in the hippocampus of rat pups at puberty
by: Bovorn Veerawatananan, et al.
Published: (2016-06-01)

β3 Adrenergic Receptor Agonist Mirabegron Increases AQP2 and NKCC2 Urinary Excretion in OAB Patients: A Pleiotropic Effect of Interest for Patients with X-Linked Nephrogenic Diabetes Insipidus
by: Serena Milano, et al.
Published: (2023-01-01)

Biochemistry and Immune Biomarkers Indicate Interacting Effects of Pre- and Postnatal Stressors in Pigs across Sexes
by: Haley E. Rymut, et al.
Published: (2021-04-01)

Differential Expression of Endogenous Retroviruses and Inflammatory Mediators in Female and Male Offspring in a Mouse Model of Maternal Immune Activation
by: Chiara Cipriani, et al.
Published: (2022-11-01)

Long-Lasting Impact of Maternal Immune Activation and Interaction With a Second Immune Challenge on Pig Behavior
by: Haley E. Rymut, et al.
Published: (2020-11-01)

The Poly I:C maternal immune stimulation model shows unique patterns of brain metabolism, morphometry, and plasticity in female rats
by: Marta Casquero-Veiga, et al.
Published: (2023-01-01)

Paliperidone Reversion of Maternal Immune Activation-Induced Changes on Brain Serotonin and Kynurenine Pathways
by: Karina S. MacDowell, et al.
Published: (2021-05-01)

Kidney Injury Causes Accumulation of Renal Sodium That Modulates Renal Lymphatic Dynamics
by: Jing Liu, et al.
Published: (2022-01-01)