An Overview of Diagnostic and Management Strategies for Talaromycosis, an Underrated Disease
Underrated and neglected, talaromycosis is a life-threatening fungal disease endemic to the tropical and subtropical regions of Asia. In China, it has been reported that talaromycosis mortality doubles from 24 to 50% when the diagnosis is delayed, and reaches 100% when the diagnosis is missed. Thus,...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Journal of Fungi |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2309-608X/9/6/647 |
| _version_ | 1797594016022265856 |
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| author | Silvere D. Zaongo Fazhen Zhang Yaokai Chen |
| author_facet | Silvere D. Zaongo Fazhen Zhang Yaokai Chen |
| author_sort | Silvere D. Zaongo |
| collection | DOAJ |
| description | Underrated and neglected, talaromycosis is a life-threatening fungal disease endemic to the tropical and subtropical regions of Asia. In China, it has been reported that talaromycosis mortality doubles from 24 to 50% when the diagnosis is delayed, and reaches 100% when the diagnosis is missed. Thus, the accurate diagnosis of talaromycosis is of utmost importance. Herein, in the first part of this article, we provide an extensive review of the diagnostic tools used thus far by physicians in the management of cases of talaromycosis. The challenges encountered and the perspectives which may aid in the discovery of more accurate and reliable diagnostic approaches are also discussed. In the second part of this review, we discuss the drugs used to prevent and treat <i>T. marneffei</i> infection. Alternative therapeutic options and potential drug resistance reported in the contemporary literature are also discussed. We aim to guide researchers towards the discovery of novel approaches to prevent, diagnose, and treat talaromycosis, and therefore improve the prognosis for those afflicted by this important disease. |
| first_indexed | 2024-03-11T02:16:38Z |
| format | Article |
| id | doaj.art-ad02deeebeba4fe0967afcff44801aed |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-11T02:16:38Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-ad02deeebeba4fe0967afcff44801aed2023-11-18T11:08:53ZengMDPI AGJournal of Fungi2309-608X2023-06-019664710.3390/jof9060647An Overview of Diagnostic and Management Strategies for Talaromycosis, an Underrated DiseaseSilvere D. Zaongo0Fazhen Zhang1Yaokai Chen2Department of Infectious Diseases, Chongqing Public Health Medical Center, Chongqing 400036, ChinaFifth Unit for Tuberculosis, Chongqing Public Health Medical Center, Chongqing 400036, ChinaDepartment of Infectious Diseases, Chongqing Public Health Medical Center, Chongqing 400036, ChinaUnderrated and neglected, talaromycosis is a life-threatening fungal disease endemic to the tropical and subtropical regions of Asia. In China, it has been reported that talaromycosis mortality doubles from 24 to 50% when the diagnosis is delayed, and reaches 100% when the diagnosis is missed. Thus, the accurate diagnosis of talaromycosis is of utmost importance. Herein, in the first part of this article, we provide an extensive review of the diagnostic tools used thus far by physicians in the management of cases of talaromycosis. The challenges encountered and the perspectives which may aid in the discovery of more accurate and reliable diagnostic approaches are also discussed. In the second part of this review, we discuss the drugs used to prevent and treat <i>T. marneffei</i> infection. Alternative therapeutic options and potential drug resistance reported in the contemporary literature are also discussed. We aim to guide researchers towards the discovery of novel approaches to prevent, diagnose, and treat talaromycosis, and therefore improve the prognosis for those afflicted by this important disease.https://www.mdpi.com/2309-608X/9/6/647<i>T. marneffei</i>talaromycosisdiagnosistreatmentprognosis |
| spellingShingle | Silvere D. Zaongo Fazhen Zhang Yaokai Chen An Overview of Diagnostic and Management Strategies for Talaromycosis, an Underrated Disease Journal of Fungi <i>T. marneffei</i> talaromycosis diagnosis treatment prognosis |
| title | An Overview of Diagnostic and Management Strategies for Talaromycosis, an Underrated Disease |
| title_full | An Overview of Diagnostic and Management Strategies for Talaromycosis, an Underrated Disease |
| title_fullStr | An Overview of Diagnostic and Management Strategies for Talaromycosis, an Underrated Disease |
| title_full_unstemmed | An Overview of Diagnostic and Management Strategies for Talaromycosis, an Underrated Disease |
| title_short | An Overview of Diagnostic and Management Strategies for Talaromycosis, an Underrated Disease |
| title_sort | overview of diagnostic and management strategies for talaromycosis an underrated disease |
| topic | <i>T. marneffei</i> talaromycosis diagnosis treatment prognosis |
| url | https://www.mdpi.com/2309-608X/9/6/647 |
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