Visceral adipose tissue and osteoarthritis, a two-sample Mendelian randomized study
BackgroundThe relationship between visceral adipose tissue and osteoarthritis is not clear. The purpose of our study was to explore the relationship between visceral adipose tissue and osteoarthritis.MethodsWe used a two-sample Mendelian randomization method to select single-nucleotide polymorphisms...
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1324449/full |
| _version_ | 1797365529440157696 |
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| author | Yinzhen Zhang Yanpeng Wang Ji Xu Zhengyan Wang Wenhai Zhao Changwei Zhao |
| author_facet | Yinzhen Zhang Yanpeng Wang Ji Xu Zhengyan Wang Wenhai Zhao Changwei Zhao |
| author_sort | Yinzhen Zhang |
| collection | DOAJ |
| description | BackgroundThe relationship between visceral adipose tissue and osteoarthritis is not clear. The purpose of our study was to explore the relationship between visceral adipose tissue and osteoarthritis.MethodsWe used a two-sample Mendelian randomization method to select single-nucleotide polymorphisms (SNPs) significantly associated with visceral adipose tissue as instrumental variables to explore the relationship between visceral adipose tissue and all osteoarthritis, hand osteoarthritis, hip osteoarthritis, knee osteoarthritis, and spine osteoarthritis. The reliability of the results was tested using sensitivity analysis.ResultsOur findings indicated that visceral adipose tissue was associated with all osteoarthritis, hip osteoarthritis, knee osteoarthritis, and spine osteoarthritis (all osteoarthritis: OR = 1.399, 95% CI: 1.335–1.467, p = 7.95e-44; hip osteoarthritis: OR = 1.399, 95% CI: 1.284–1.524, p = 1.41e-14; knee osteoarthritis: OR = 1.794, 95% CI: 1.662–1.937, p = 1.33e-50; and spine osteoarthritis: OR = 1.445, 95% CI: 1.314–1.589, p = 2.89e-14). Sensitivity analysis demonstrated the reliability of these results.ConclusionOur study suggests that genetically predicted visceral adipose tissue is associated with osteoarthritis. Reducing the accumulation of visceral adipose tissue could potentially have an impact on the incidence of osteoarthritis. |
| first_indexed | 2024-03-08T16:50:17Z |
| format | Article |
| id | doaj.art-ad03e6a9d8784bf7955f1ae38d3ec31b |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-08T16:50:17Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-ad03e6a9d8784bf7955f1ae38d3ec31b2024-01-05T05:03:55ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2024-01-011010.3389/fmed.2023.13244491324449Visceral adipose tissue and osteoarthritis, a two-sample Mendelian randomized studyYinzhen Zhang0Yanpeng Wang1Ji Xu2Zhengyan Wang3Wenhai Zhao4Changwei Zhao5Department of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, ChinaDepartment of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, ChinaDepartment of Spinal Orthopedics, Weifang Hospital of Traditional Chinese Medicine, Weifang, ChinaDepartment of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, ChinaDepartment of Orthopedics, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, ChinaDepartment of Orthopedics, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, ChinaBackgroundThe relationship between visceral adipose tissue and osteoarthritis is not clear. The purpose of our study was to explore the relationship between visceral adipose tissue and osteoarthritis.MethodsWe used a two-sample Mendelian randomization method to select single-nucleotide polymorphisms (SNPs) significantly associated with visceral adipose tissue as instrumental variables to explore the relationship between visceral adipose tissue and all osteoarthritis, hand osteoarthritis, hip osteoarthritis, knee osteoarthritis, and spine osteoarthritis. The reliability of the results was tested using sensitivity analysis.ResultsOur findings indicated that visceral adipose tissue was associated with all osteoarthritis, hip osteoarthritis, knee osteoarthritis, and spine osteoarthritis (all osteoarthritis: OR = 1.399, 95% CI: 1.335–1.467, p = 7.95e-44; hip osteoarthritis: OR = 1.399, 95% CI: 1.284–1.524, p = 1.41e-14; knee osteoarthritis: OR = 1.794, 95% CI: 1.662–1.937, p = 1.33e-50; and spine osteoarthritis: OR = 1.445, 95% CI: 1.314–1.589, p = 2.89e-14). Sensitivity analysis demonstrated the reliability of these results.ConclusionOur study suggests that genetically predicted visceral adipose tissue is associated with osteoarthritis. Reducing the accumulation of visceral adipose tissue could potentially have an impact on the incidence of osteoarthritis.https://www.frontiersin.org/articles/10.3389/fmed.2023.1324449/fullobesityvisceral adipose tissueosteoarthritisMendelian randomizationtwo-sample MR |
| spellingShingle | Yinzhen Zhang Yanpeng Wang Ji Xu Zhengyan Wang Wenhai Zhao Changwei Zhao Visceral adipose tissue and osteoarthritis, a two-sample Mendelian randomized study Frontiers in Medicine obesity visceral adipose tissue osteoarthritis Mendelian randomization two-sample MR |
| title | Visceral adipose tissue and osteoarthritis, a two-sample Mendelian randomized study |
| title_full | Visceral adipose tissue and osteoarthritis, a two-sample Mendelian randomized study |
| title_fullStr | Visceral adipose tissue and osteoarthritis, a two-sample Mendelian randomized study |
| title_full_unstemmed | Visceral adipose tissue and osteoarthritis, a two-sample Mendelian randomized study |
| title_short | Visceral adipose tissue and osteoarthritis, a two-sample Mendelian randomized study |
| title_sort | visceral adipose tissue and osteoarthritis a two sample mendelian randomized study |
| topic | obesity visceral adipose tissue osteoarthritis Mendelian randomization two-sample MR |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1324449/full |
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