Persistent hyperparathyroidism secondary to ectopic parathyroid adenoma in lung: Case report
Primary hyperparathyroidism (PHPT) is the most prevalent cause of hypercalcemia, affecting 0.3% of the population. The only curative procedure is parathyroidectomy. Persistent PHPT occurs in 4.7 percent of patients, even in the most skilled hands. Ectopic adenomas are challenging to localize before...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.988035/full |
| _version_ | 1811293594362839040 |
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| author | Majid Valizadeh Amir Ebadinejad Atieh Amouzegar Anahita Zakeri Anahita Zakeri |
| author_facet | Majid Valizadeh Amir Ebadinejad Atieh Amouzegar Anahita Zakeri Anahita Zakeri |
| author_sort | Majid Valizadeh |
| collection | DOAJ |
| description | Primary hyperparathyroidism (PHPT) is the most prevalent cause of hypercalcemia, affecting 0.3% of the population. The only curative procedure is parathyroidectomy. Persistent PHPT occurs in 4.7 percent of patients, even in the most skilled hands. Ectopic adenomas are challenging to localize before and during surgery and frequently result in persistent PHPT. We presented a case with persistent PHPT due to lung parathyroid adenoma that was successfully resected with video-assisted thoracoscopic surgery. A 55-year-old female patient was admitted to our endocrinology clinic with persistent PHPT after four neck explorations over 16 years. The last 99m Tc-MIBI scintigraphy with SPECT showed nothing suggestive of parathyroid adenoma, neither in the neck nor the mediastinum, but a solitary nodule as an incidental finding was reported in the lower lobe of the right lung, which was highly probable for a parathyroid adenoma in a fluorodeoxyglucose PET scan. Pathological examination ruled out parathyromatosis and lung malignancy; despite its location outside the anticipated embryonic pathway, pathology revealed the presence of an ectopic parathyroid adenoma. After the surgery, serum parathyroid hormone and calcium levels decreased, and hypoparathyroidism was corrected with calcium carbonate and calcitriol. |
| first_indexed | 2024-04-13T05:03:45Z |
| format | Article |
| id | doaj.art-ad0457c04830461097f8f073c5a88e14 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-13T05:03:45Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-ad0457c04830461097f8f073c5a88e142022-12-22T03:01:14ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-12-011310.3389/fendo.2022.988035988035Persistent hyperparathyroidism secondary to ectopic parathyroid adenoma in lung: Case reportMajid Valizadeh0Amir Ebadinejad1Atieh Amouzegar2Anahita Zakeri3Anahita Zakeri4Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranObesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranEndocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranObesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Internal Medicine, Emam Khomeini Hospital, Ardabil University of Medical Science, Ardabil, IranPrimary hyperparathyroidism (PHPT) is the most prevalent cause of hypercalcemia, affecting 0.3% of the population. The only curative procedure is parathyroidectomy. Persistent PHPT occurs in 4.7 percent of patients, even in the most skilled hands. Ectopic adenomas are challenging to localize before and during surgery and frequently result in persistent PHPT. We presented a case with persistent PHPT due to lung parathyroid adenoma that was successfully resected with video-assisted thoracoscopic surgery. A 55-year-old female patient was admitted to our endocrinology clinic with persistent PHPT after four neck explorations over 16 years. The last 99m Tc-MIBI scintigraphy with SPECT showed nothing suggestive of parathyroid adenoma, neither in the neck nor the mediastinum, but a solitary nodule as an incidental finding was reported in the lower lobe of the right lung, which was highly probable for a parathyroid adenoma in a fluorodeoxyglucose PET scan. Pathological examination ruled out parathyromatosis and lung malignancy; despite its location outside the anticipated embryonic pathway, pathology revealed the presence of an ectopic parathyroid adenoma. After the surgery, serum parathyroid hormone and calcium levels decreased, and hypoparathyroidism was corrected with calcium carbonate and calcitriol.https://www.frontiersin.org/articles/10.3389/fendo.2022.988035/fullectopic parathyroid adenomahyperparathyroidismvideo-assisted thoracoscopic surgery (VATS)embryologic anomalyMIBI scan |
| spellingShingle | Majid Valizadeh Amir Ebadinejad Atieh Amouzegar Anahita Zakeri Anahita Zakeri Persistent hyperparathyroidism secondary to ectopic parathyroid adenoma in lung: Case report Frontiers in Endocrinology ectopic parathyroid adenoma hyperparathyroidism video-assisted thoracoscopic surgery (VATS) embryologic anomaly MIBI scan |
| title | Persistent hyperparathyroidism secondary to ectopic parathyroid adenoma in lung: Case report |
| title_full | Persistent hyperparathyroidism secondary to ectopic parathyroid adenoma in lung: Case report |
| title_fullStr | Persistent hyperparathyroidism secondary to ectopic parathyroid adenoma in lung: Case report |
| title_full_unstemmed | Persistent hyperparathyroidism secondary to ectopic parathyroid adenoma in lung: Case report |
| title_short | Persistent hyperparathyroidism secondary to ectopic parathyroid adenoma in lung: Case report |
| title_sort | persistent hyperparathyroidism secondary to ectopic parathyroid adenoma in lung case report |
| topic | ectopic parathyroid adenoma hyperparathyroidism video-assisted thoracoscopic surgery (VATS) embryologic anomaly MIBI scan |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.988035/full |
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