Endothelial Dysfunction in Diabetes Mellitus: New Insights
Endothelial dysfunction (ED) is an important marker of future atherosclerosis and cardiovascular disease, especially in people with diabetes. This article summarizes the evidence on endothelial dysfunction in people with diabetes and adds different perspectives that can affect the presence and sever...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/13/10705 |
| _version_ | 1797591574943629312 |
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| author | Michal Dubsky Jiri Veleba Dominika Sojakova Natalia Marhefkova Vladimira Fejfarova Edward B. Jude |
| author_facet | Michal Dubsky Jiri Veleba Dominika Sojakova Natalia Marhefkova Vladimira Fejfarova Edward B. Jude |
| author_sort | Michal Dubsky |
| collection | DOAJ |
| description | Endothelial dysfunction (ED) is an important marker of future atherosclerosis and cardiovascular disease, especially in people with diabetes. This article summarizes the evidence on endothelial dysfunction in people with diabetes and adds different perspectives that can affect the presence and severity of ED and its consequences. We highlight that data on ED in type 1 diabetes are lacking and discuss the relationship between ED and arterial stiffness. Several interesting studies have been published showing that ED modulates microRNA, microvesicles, lipid levels, and the endoplasmatic reticulum. A better understanding of ED could provide important insights into the microvascular complications of diabetes, their treatment, and even their prevention. |
| first_indexed | 2024-03-11T01:40:17Z |
| format | Article |
| id | doaj.art-ad07afe3606c4619b2d326d6537574eb |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T01:40:17Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ad07afe3606c4619b2d326d6537574eb2023-11-18T16:42:16ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-06-0124131070510.3390/ijms241310705Endothelial Dysfunction in Diabetes Mellitus: New InsightsMichal Dubsky0Jiri Veleba1Dominika Sojakova2Natalia Marhefkova3Vladimira Fejfarova4Edward B. Jude5Diabetes Centre, Institute for Clinical and Experimental Medicine, 14021 Prague, Czech RepublicDiabetes Centre, Institute for Clinical and Experimental Medicine, 14021 Prague, Czech RepublicDiabetes Centre, Institute for Clinical and Experimental Medicine, 14021 Prague, Czech RepublicDiabetes Centre, Institute for Clinical and Experimental Medicine, 14021 Prague, Czech RepublicDiabetes Centre, Institute for Clinical and Experimental Medicine, 14021 Prague, Czech RepublicDiabetes Center, Tameside and Glossop Integrated Care NHS Foundation Trust, Ashton-under-Lyne OL6 9RW, UKEndothelial dysfunction (ED) is an important marker of future atherosclerosis and cardiovascular disease, especially in people with diabetes. This article summarizes the evidence on endothelial dysfunction in people with diabetes and adds different perspectives that can affect the presence and severity of ED and its consequences. We highlight that data on ED in type 1 diabetes are lacking and discuss the relationship between ED and arterial stiffness. Several interesting studies have been published showing that ED modulates microRNA, microvesicles, lipid levels, and the endoplasmatic reticulum. A better understanding of ED could provide important insights into the microvascular complications of diabetes, their treatment, and even their prevention.https://www.mdpi.com/1422-0067/24/13/10705endothelial dysfunctiondiabetes mellitusvascular healtharterial stiffness |
| spellingShingle | Michal Dubsky Jiri Veleba Dominika Sojakova Natalia Marhefkova Vladimira Fejfarova Edward B. Jude Endothelial Dysfunction in Diabetes Mellitus: New Insights International Journal of Molecular Sciences endothelial dysfunction diabetes mellitus vascular health arterial stiffness |
| title | Endothelial Dysfunction in Diabetes Mellitus: New Insights |
| title_full | Endothelial Dysfunction in Diabetes Mellitus: New Insights |
| title_fullStr | Endothelial Dysfunction in Diabetes Mellitus: New Insights |
| title_full_unstemmed | Endothelial Dysfunction in Diabetes Mellitus: New Insights |
| title_short | Endothelial Dysfunction in Diabetes Mellitus: New Insights |
| title_sort | endothelial dysfunction in diabetes mellitus new insights |
| topic | endothelial dysfunction diabetes mellitus vascular health arterial stiffness |
| url | https://www.mdpi.com/1422-0067/24/13/10705 |
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