HbA1c and Platelet indices correlation in type 2 diabetes patients
Background: Diabetes mellitus is a metabolic disorder represented by persistent hyperglycemia, which significantly elevates the risk of cardiovascular complications. Platelet dysfunction plays a crucial role in the development of these complications. While HbA1c is a widely employed diagnostic marke...
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| Format: | Article |
| Language: | English |
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National Board of Examinations
2023-06-01
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| Series: | National Board of Examinations Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://natboard.edu.in/ejournal/articledtl?x=QitsN0pBT25VRnFFSktXdjVYWkV5UT09 |
| _version_ | 1797364317278961664 |
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| author | S. Viswanadha Reddy Pulkit Jindal Kshitiz Vashista |
| author_facet | S. Viswanadha Reddy Pulkit Jindal Kshitiz Vashista |
| author_sort | S. Viswanadha Reddy |
| collection | DOAJ |
| description | Background: Diabetes mellitus is a metabolic disorder represented by persistent hyperglycemia, which significantly elevates the risk of cardiovascular complications. Platelet dysfunction plays a crucial role in the development of these complications. While HbA1c is a widely employed diagnostic marker for diabetes, its association with platelet indices, reflecting platelet size and activity, in type 2 diabetes patients remains poorly understood. Recent research has increasingly emphasized platelet activation as a key contributing factor to atherothrombotic processes in individuals with diabetes.
Aim: Present study aims to find if there is any correlation between platelet indices and HbA1c. Discussion: Hyperglycemia leads to reactive oxygen species and AGEs formation, resulting in endothelial dysfunction. The combination of increased intracellular calcium, decreased cAMP levels, and oxidative stress contributes to platelet hyperactivity. Endothelial dysfunction exacerbates this hyperactivity and manifests as an increase in platelet size and alterations in platelet indices.
Conclusion: Our research findings indicate that diabetes mellitus exhibits larger and more active platelets, resulting in an elevated thrombogenic potential. It also revealed a direct and positive correlation between platelet indices and HbA1c levels. |
| first_indexed | 2024-03-08T16:33:31Z |
| format | Article |
| id | doaj.art-ad08695046ce4043a732dbba4642db22 |
| institution | Directory Open Access Journal |
| issn | 2583-7524 |
| language | English |
| last_indexed | 2024-03-08T16:33:31Z |
| publishDate | 2023-06-01 |
| publisher | National Board of Examinations |
| record_format | Article |
| series | National Board of Examinations Journal of Medical Sciences |
| spelling | doaj.art-ad08695046ce4043a732dbba4642db222024-01-06T02:20:34ZengNational Board of ExaminationsNational Board of Examinations Journal of Medical Sciences2583-75242023-06-011633934810.61770/NBEJMS.2023.v01.i06.003HbA1c and Platelet indices correlation in type 2 diabetes patientsS. Viswanadha Reddy0Pulkit Jindal1Kshitiz Vashista2Resident, Department of Internal Medicine, Government Multi specialty Hospital, ChandigarhResident, Department of Internal Medicine, Government Multi specialty Hospital, ChandigarhMedical Officer, Department of Internal Medicine, Government Multi specialty Hospital, ChandigarhBackground: Diabetes mellitus is a metabolic disorder represented by persistent hyperglycemia, which significantly elevates the risk of cardiovascular complications. Platelet dysfunction plays a crucial role in the development of these complications. While HbA1c is a widely employed diagnostic marker for diabetes, its association with platelet indices, reflecting platelet size and activity, in type 2 diabetes patients remains poorly understood. Recent research has increasingly emphasized platelet activation as a key contributing factor to atherothrombotic processes in individuals with diabetes. Aim: Present study aims to find if there is any correlation between platelet indices and HbA1c. Discussion: Hyperglycemia leads to reactive oxygen species and AGEs formation, resulting in endothelial dysfunction. The combination of increased intracellular calcium, decreased cAMP levels, and oxidative stress contributes to platelet hyperactivity. Endothelial dysfunction exacerbates this hyperactivity and manifests as an increase in platelet size and alterations in platelet indices. Conclusion: Our research findings indicate that diabetes mellitus exhibits larger and more active platelets, resulting in an elevated thrombogenic potential. It also revealed a direct and positive correlation between platelet indices and HbA1c levels.https://natboard.edu.in/ejournal/articledtl?x=QitsN0pBT25VRnFFSktXdjVYWkV5UT09hba1cmpvpdwp-lcrplatelet indices |
| spellingShingle | S. Viswanadha Reddy Pulkit Jindal Kshitiz Vashista HbA1c and Platelet indices correlation in type 2 diabetes patients National Board of Examinations Journal of Medical Sciences hba1c mpv pdw p-lcr platelet indices |
| title | HbA1c and Platelet indices correlation in type 2 diabetes patients |
| title_full | HbA1c and Platelet indices correlation in type 2 diabetes patients |
| title_fullStr | HbA1c and Platelet indices correlation in type 2 diabetes patients |
| title_full_unstemmed | HbA1c and Platelet indices correlation in type 2 diabetes patients |
| title_short | HbA1c and Platelet indices correlation in type 2 diabetes patients |
| title_sort | hba1c and platelet indices correlation in type 2 diabetes patients |
| topic | hba1c mpv pdw p-lcr platelet indices |
| url | https://natboard.edu.in/ejournal/articledtl?x=QitsN0pBT25VRnFFSktXdjVYWkV5UT09 |
| work_keys_str_mv | AT sviswanadhareddy hba1candplateletindicescorrelationintype2diabetespatients AT pulkitjindal hba1candplateletindicescorrelationintype2diabetespatients AT kshitizvashista hba1candplateletindicescorrelationintype2diabetespatients |