Quantifiable features of a tidal breathing phenotype in dogs with severe bronchomalacia diagnosed by bronchoscopy
AbstractDynamic lower airway obstruction is the primary component of canine bronchomalacia, but the ventilatory function remains underinvestigated. This prospective study analyzed tidal breathing characteristics in 28 dogs, comprising 14 with severe bronchomalacia diagnosed by bronchoscopy versus 14...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Veterinary Quarterly |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/01652176.2023.2252518 |
| _version_ | 1797391741006905344 |
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| author | Chung-Hui Lin Lynelle R. Johnson Wei-Tao Chang Pei-Ying Lo Hui-Wen Chen Huey-Dong Wu |
| author_facet | Chung-Hui Lin Lynelle R. Johnson Wei-Tao Chang Pei-Ying Lo Hui-Wen Chen Huey-Dong Wu |
| author_sort | Chung-Hui Lin |
| collection | DOAJ |
| description | AbstractDynamic lower airway obstruction is the primary component of canine bronchomalacia, but the ventilatory function remains underinvestigated. This prospective study analyzed tidal breathing characteristics in 28 dogs, comprising 14 with severe bronchomalacia diagnosed by bronchoscopy versus 14 without respiratory disease. Spirometry was conducted in all dogs. Bronchoscopy with bronchoalveolar lavage or brush under anesthesia was performed in 14 dogs with cough and expiratory effort. Severe bronchomalacia was defined by the severity of collapse and total number of bronchi affected. Ventilatory characteristics were compared between groups. Results revealed that dogs with severe bronchomalacia had lower minute volume (218 vs 338 mL/kg, p = .039) and greater expiratory-to-inspiratory time ratio (1.55 vs 1.35, p = .01) compared to control dogs. The tidal breathing pattern of dogs with bronchomalacia was different from that of normal dogs, and the pattern differed from the concave or flat expiratory curves typical of lower airway obstruction. Compared to control dogs, dogs with severe bronchomalacia had a significantly prolonged low-flow expiratory phase (p < .001) on the flow-time plot and a more exponential shape of the expiratory curve (p < .001) on the volume-time plot. Flow-time index ExpLF/Te (>0.14) and volume-time index Vt-AUCexp (≤31%) had a high ROC-AUC (1.00, 95% confidence interval 0.88 to 1.00) in predicting severe bronchomalacia. In conclusion, the tidal breathing pattern identified here indicates abnormal and complicated ventilatory mechanics in dogs with severe bronchomalacia. The role of this pulmonary functional phenotype should be investigated for disease progression and therapeutic monitoring in canine bronchomalacia. |
| first_indexed | 2024-03-08T23:37:04Z |
| format | Article |
| id | doaj.art-ad08856a59224fcbb150d8ec66aafb8a |
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| issn | 0165-2176 1875-5941 |
| language | English |
| last_indexed | 2024-03-08T23:37:04Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Veterinary Quarterly |
| spelling | doaj.art-ad08856a59224fcbb150d8ec66aafb8a2023-12-14T06:25:09ZengTaylor & Francis GroupVeterinary Quarterly0165-21761875-59412023-12-0143111010.1080/01652176.2023.2252518Quantifiable features of a tidal breathing phenotype in dogs with severe bronchomalacia diagnosed by bronchoscopyChung-Hui Lin0Lynelle R. Johnson1Wei-Tao Chang2Pei-Ying Lo3Hui-Wen Chen4Huey-Dong Wu5National Taiwan University Veterinary Hospital, National Taiwan University, Taipei, TaiwanDepartment of Medicine and Epidemiology, The University of California School of Veterinary Medicine, Davis, CA, USANational Taiwan University Veterinary Hospital, National Taiwan University, Taipei, TaiwanTACS-Alliance Research Center, Taipei, TaiwanDepartment of Veterinary Medicine, National Taiwan University, Taipei, TaiwanSection of Respiratory Therapy, Department of Integrated Diagnostics and Therapeutics, National Taiwan University Hospital, National Taiwan University, Taipei, TaiwanAbstractDynamic lower airway obstruction is the primary component of canine bronchomalacia, but the ventilatory function remains underinvestigated. This prospective study analyzed tidal breathing characteristics in 28 dogs, comprising 14 with severe bronchomalacia diagnosed by bronchoscopy versus 14 without respiratory disease. Spirometry was conducted in all dogs. Bronchoscopy with bronchoalveolar lavage or brush under anesthesia was performed in 14 dogs with cough and expiratory effort. Severe bronchomalacia was defined by the severity of collapse and total number of bronchi affected. Ventilatory characteristics were compared between groups. Results revealed that dogs with severe bronchomalacia had lower minute volume (218 vs 338 mL/kg, p = .039) and greater expiratory-to-inspiratory time ratio (1.55 vs 1.35, p = .01) compared to control dogs. The tidal breathing pattern of dogs with bronchomalacia was different from that of normal dogs, and the pattern differed from the concave or flat expiratory curves typical of lower airway obstruction. Compared to control dogs, dogs with severe bronchomalacia had a significantly prolonged low-flow expiratory phase (p < .001) on the flow-time plot and a more exponential shape of the expiratory curve (p < .001) on the volume-time plot. Flow-time index ExpLF/Te (>0.14) and volume-time index Vt-AUCexp (≤31%) had a high ROC-AUC (1.00, 95% confidence interval 0.88 to 1.00) in predicting severe bronchomalacia. In conclusion, the tidal breathing pattern identified here indicates abnormal and complicated ventilatory mechanics in dogs with severe bronchomalacia. The role of this pulmonary functional phenotype should be investigated for disease progression and therapeutic monitoring in canine bronchomalacia.https://www.tandfonline.com/doi/10.1080/01652176.2023.2252518Bronchomalaciabronchoscopydogsfunctional phenotypelower airway obstructionpulmonary function test |
| spellingShingle | Chung-Hui Lin Lynelle R. Johnson Wei-Tao Chang Pei-Ying Lo Hui-Wen Chen Huey-Dong Wu Quantifiable features of a tidal breathing phenotype in dogs with severe bronchomalacia diagnosed by bronchoscopy Veterinary Quarterly Bronchomalacia bronchoscopy dogs functional phenotype lower airway obstruction pulmonary function test |
| title | Quantifiable features of a tidal breathing phenotype in dogs with severe bronchomalacia diagnosed by bronchoscopy |
| title_full | Quantifiable features of a tidal breathing phenotype in dogs with severe bronchomalacia diagnosed by bronchoscopy |
| title_fullStr | Quantifiable features of a tidal breathing phenotype in dogs with severe bronchomalacia diagnosed by bronchoscopy |
| title_full_unstemmed | Quantifiable features of a tidal breathing phenotype in dogs with severe bronchomalacia diagnosed by bronchoscopy |
| title_short | Quantifiable features of a tidal breathing phenotype in dogs with severe bronchomalacia diagnosed by bronchoscopy |
| title_sort | quantifiable features of a tidal breathing phenotype in dogs with severe bronchomalacia diagnosed by bronchoscopy |
| topic | Bronchomalacia bronchoscopy dogs functional phenotype lower airway obstruction pulmonary function test |
| url | https://www.tandfonline.com/doi/10.1080/01652176.2023.2252518 |
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