Phytochemical Characterization of Chamomile (<i>Matricaria recutita</i> L.) Roots and Evaluation of Their Antioxidant and Antibacterial Potential
<i>Matricaria recutita</i> L., German chamomile, is one of the most widely used medicinal plants, whose efficacy has been proven in numerous studies. However, its roots have attracted only little interest so far, since mainly above-ground plant parts are used for medicinal purposes. To b...
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MDPI AG
2022-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/23/8508 |
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| author | Lilo K. Mailänder Peter Lorenz Hannes Bitterling Florian C. Stintzing Rolf Daniels Dietmar R. Kammerer |
| author_facet | Lilo K. Mailänder Peter Lorenz Hannes Bitterling Florian C. Stintzing Rolf Daniels Dietmar R. Kammerer |
| author_sort | Lilo K. Mailänder |
| collection | DOAJ |
| description | <i>Matricaria recutita</i> L., German chamomile, is one of the most widely used medicinal plants, whose efficacy has been proven in numerous studies. However, its roots have attracted only little interest so far, since mainly above-ground plant parts are used for medicinal purposes. To broaden the knowledge of chamomile roots, a profound phytochemical characterization was performed along with a bioactivity screening of corresponding root extracts. While volatile constituents such as chamomillol and polyynes were detected using GC-MS, HPLC-MS<sup>n</sup> analyses revealed the occurrence of four coumarin glycosides, more than ten phenolic acid esters and five glyceroglycolipids. Furthermore, the antioxidant activity of the extracts was evaluated. Polar extracts revealed IC<sub>50</sub> values ranging from 13 to 57 µg/mL in the DPPH radical scavenging assay, which is in the same range as reported for chamomile flower extracts. In addition, superoxide radical scavenging potential and mild antibacterial effects against <i>S. aureus</i> und <i>B. subtilis</i> were demonstrated. Moreover, to assess interspecies variation in chamomile roots, extracts of <i>M. recutita</i> were compared to those of <i>M. discoidea</i> DC. Interestingly, the latter revealed stronger antioxidant activity. The presented results aim at the valorization of chamomile roots, previously discarded as by-product of chamomile flower production, as a sustainable source of bioactive phytochemicals. |
| first_indexed | 2024-03-09T17:38:56Z |
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| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T17:38:56Z |
| publishDate | 2022-12-01 |
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| record_format | Article |
| series | Molecules |
| spelling | doaj.art-ad0933d228b047899a9512fe4162b8d62023-11-24T11:43:25ZengMDPI AGMolecules1420-30492022-12-012723850810.3390/molecules27238508Phytochemical Characterization of Chamomile (<i>Matricaria recutita</i> L.) Roots and Evaluation of Their Antioxidant and Antibacterial PotentialLilo K. Mailänder0Peter Lorenz1Hannes Bitterling2Florian C. Stintzing3Rolf Daniels4Dietmar R. Kammerer5Department of Analytical Development and Research, Section Phytochemical Research, WALA Heilmittel GmbH, Dorfstraße 1, DE-73087 Bad Boll/Eckwälden, GermanyDepartment of Analytical Development and Research, Section Phytochemical Research, WALA Heilmittel GmbH, Dorfstraße 1, DE-73087 Bad Boll/Eckwälden, GermanyDepartment of Analytical Development and Research, Section Phytochemical Research, WALA Heilmittel GmbH, Dorfstraße 1, DE-73087 Bad Boll/Eckwälden, GermanyDepartment of Analytical Development and Research, Section Phytochemical Research, WALA Heilmittel GmbH, Dorfstraße 1, DE-73087 Bad Boll/Eckwälden, GermanyDepartment of Pharmaceutical Technology, Tübingen University, Auf der Morgenstelle 8, DE-72076 Tübingen, GermanyDepartment of Analytical Development and Research, Section Phytochemical Research, WALA Heilmittel GmbH, Dorfstraße 1, DE-73087 Bad Boll/Eckwälden, Germany<i>Matricaria recutita</i> L., German chamomile, is one of the most widely used medicinal plants, whose efficacy has been proven in numerous studies. However, its roots have attracted only little interest so far, since mainly above-ground plant parts are used for medicinal purposes. To broaden the knowledge of chamomile roots, a profound phytochemical characterization was performed along with a bioactivity screening of corresponding root extracts. While volatile constituents such as chamomillol and polyynes were detected using GC-MS, HPLC-MS<sup>n</sup> analyses revealed the occurrence of four coumarin glycosides, more than ten phenolic acid esters and five glyceroglycolipids. Furthermore, the antioxidant activity of the extracts was evaluated. Polar extracts revealed IC<sub>50</sub> values ranging from 13 to 57 µg/mL in the DPPH radical scavenging assay, which is in the same range as reported for chamomile flower extracts. In addition, superoxide radical scavenging potential and mild antibacterial effects against <i>S. aureus</i> und <i>B. subtilis</i> were demonstrated. Moreover, to assess interspecies variation in chamomile roots, extracts of <i>M. recutita</i> were compared to those of <i>M. discoidea</i> DC. Interestingly, the latter revealed stronger antioxidant activity. The presented results aim at the valorization of chamomile roots, previously discarded as by-product of chamomile flower production, as a sustainable source of bioactive phytochemicals.https://www.mdpi.com/1420-3049/27/23/8508<i>Matricaria chamomilla</i> L.<i>Matricaria discoidea</i> DC.phytoextractHPLC-MSGC-MSbioactive constituents |
| spellingShingle | Lilo K. Mailänder Peter Lorenz Hannes Bitterling Florian C. Stintzing Rolf Daniels Dietmar R. Kammerer Phytochemical Characterization of Chamomile (<i>Matricaria recutita</i> L.) Roots and Evaluation of Their Antioxidant and Antibacterial Potential Molecules <i>Matricaria chamomilla</i> L. <i>Matricaria discoidea</i> DC. phytoextract HPLC-MS GC-MS bioactive constituents |
| title | Phytochemical Characterization of Chamomile (<i>Matricaria recutita</i> L.) Roots and Evaluation of Their Antioxidant and Antibacterial Potential |
| title_full | Phytochemical Characterization of Chamomile (<i>Matricaria recutita</i> L.) Roots and Evaluation of Their Antioxidant and Antibacterial Potential |
| title_fullStr | Phytochemical Characterization of Chamomile (<i>Matricaria recutita</i> L.) Roots and Evaluation of Their Antioxidant and Antibacterial Potential |
| title_full_unstemmed | Phytochemical Characterization of Chamomile (<i>Matricaria recutita</i> L.) Roots and Evaluation of Their Antioxidant and Antibacterial Potential |
| title_short | Phytochemical Characterization of Chamomile (<i>Matricaria recutita</i> L.) Roots and Evaluation of Their Antioxidant and Antibacterial Potential |
| title_sort | phytochemical characterization of chamomile i matricaria recutita i l roots and evaluation of their antioxidant and antibacterial potential |
| topic | <i>Matricaria chamomilla</i> L. <i>Matricaria discoidea</i> DC. phytoextract HPLC-MS GC-MS bioactive constituents |
| url | https://www.mdpi.com/1420-3049/27/23/8508 |
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