Sixteen New Prenylated Flavonoids from the Fruit of <i>Sinopodophyllum hexandrum</i>
Sixteen new prenylated flavonoids, sinoflavonoids P−Z (<b>1</b>−<b>11</b>) and sinoflavonoids NA−NE (<b>12</b>−<b>16</b>), were isolated from the fruit of <i>Sinopodophyllum hexandrum</i>, along with...
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MDPI AG
2019-09-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/24/17/3196 |
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| author | Yanjun Sun Haojie Chen Junmin Wang Meiling Gao Chen Zhao Ruijie Han Hui Chen Meng Li Guimin Xue Weisheng Feng |
| author_facet | Yanjun Sun Haojie Chen Junmin Wang Meiling Gao Chen Zhao Ruijie Han Hui Chen Meng Li Guimin Xue Weisheng Feng |
| author_sort | Yanjun Sun |
| collection | DOAJ |
| description | Sixteen new prenylated flavonoids, sinoflavonoids P−Z (<b>1</b>−<b>11</b>) and sinoflavonoids NA−NE (<b>12</b>−<b>16</b>), were isolated from the fruit of <i>Sinopodophyllum hexandrum</i>, along with eight known analogues (<b>17</b>−<b>24</b>). Their structures were elucidated on the basis of extensive spectroscopic data (HR-ESI-MS, <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, HSQC, HMBC). The cytotoxic activities of compounds <b>1</b>−<b>18</b>, <b>20</b>, and <b>22</b> were evaluated by MTT assay. Compound <b>6</b> showed the most potent cytotoxicity in MCF-7, and HepG2 cell lines, with IC<sub>50</sub> values of 6.25 and 3.83 μM, respectively. |
| first_indexed | 2024-12-17T03:46:54Z |
| format | Article |
| id | doaj.art-ad09503bf0904b93b3ac0d7b2115128a |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-17T03:46:54Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-ad09503bf0904b93b3ac0d7b2115128a2022-12-21T22:04:52ZengMDPI AGMolecules1420-30492019-09-012417319610.3390/molecules24173196molecules24173196Sixteen New Prenylated Flavonoids from the Fruit of <i>Sinopodophyllum hexandrum</i>Yanjun Sun0Haojie Chen1Junmin Wang2Meiling Gao3Chen Zhao4Ruijie Han5Hui Chen6Meng Li7Guimin Xue8Weisheng Feng9Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine, Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine, Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine, Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine, Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine, Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine, Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine, Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine, Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine, Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine, Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaSixteen new prenylated flavonoids, sinoflavonoids P−Z (<b>1</b>−<b>11</b>) and sinoflavonoids NA−NE (<b>12</b>−<b>16</b>), were isolated from the fruit of <i>Sinopodophyllum hexandrum</i>, along with eight known analogues (<b>17</b>−<b>24</b>). Their structures were elucidated on the basis of extensive spectroscopic data (HR-ESI-MS, <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, HSQC, HMBC). The cytotoxic activities of compounds <b>1</b>−<b>18</b>, <b>20</b>, and <b>22</b> were evaluated by MTT assay. Compound <b>6</b> showed the most potent cytotoxicity in MCF-7, and HepG2 cell lines, with IC<sub>50</sub> values of 6.25 and 3.83 μM, respectively.https://www.mdpi.com/1420-3049/24/17/3196<i>Sinopodophyllum hexandrum</i>prenylated flavonoidcytotoxic activity |
| spellingShingle | Yanjun Sun Haojie Chen Junmin Wang Meiling Gao Chen Zhao Ruijie Han Hui Chen Meng Li Guimin Xue Weisheng Feng Sixteen New Prenylated Flavonoids from the Fruit of <i>Sinopodophyllum hexandrum</i> Molecules <i>Sinopodophyllum hexandrum</i> prenylated flavonoid cytotoxic activity |
| title | Sixteen New Prenylated Flavonoids from the Fruit of <i>Sinopodophyllum hexandrum</i> |
| title_full | Sixteen New Prenylated Flavonoids from the Fruit of <i>Sinopodophyllum hexandrum</i> |
| title_fullStr | Sixteen New Prenylated Flavonoids from the Fruit of <i>Sinopodophyllum hexandrum</i> |
| title_full_unstemmed | Sixteen New Prenylated Flavonoids from the Fruit of <i>Sinopodophyllum hexandrum</i> |
| title_short | Sixteen New Prenylated Flavonoids from the Fruit of <i>Sinopodophyllum hexandrum</i> |
| title_sort | sixteen new prenylated flavonoids from the fruit of i sinopodophyllum hexandrum i |
| topic | <i>Sinopodophyllum hexandrum</i> prenylated flavonoid cytotoxic activity |
| url | https://www.mdpi.com/1420-3049/24/17/3196 |
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