Diagnostic yield of liquid‐based cytology in serial pancreatic juice aspiration cytological examination
Abstract Objectives Serial pancreatic juice aspiration cytological examination (SPACE) via endoscopic retrograde cholangiopancreatography is a useful diagnostic method for early‐stage pancreatic cancer, such as carcinoma in situ that are difficult to diagnose by endoscopic ultrasound‐guided fine nee...
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-04-01
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| Series: | DEN Open |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/deo2.177 |
| _version_ | 1797837256285749248 |
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| author | Koh Kitagawa Akira Mitoro Fumimasa Tomooka Shohei Asada Yukihisa Fujinaga Norihisa Nishimura Kosuke Kaji Hideto Kawaratani Takemi Akahane Takahiro Ozutsumi Miki Kaneko Yuki Fujimoto Yuki Tsuji Masahide Enomoto Soichi Takeda Koji Murata Takahiro Kubo Satoshi Iwai Aritoshi Koizumi Akihiko Shibamoto Junya Suzuki Misako Tanaka Takuya Matsuda Nobuyuki Yorioka Hiroyuki Masuda Masayoshi Takami Hitoshi Yoshiji |
| author_facet | Koh Kitagawa Akira Mitoro Fumimasa Tomooka Shohei Asada Yukihisa Fujinaga Norihisa Nishimura Kosuke Kaji Hideto Kawaratani Takemi Akahane Takahiro Ozutsumi Miki Kaneko Yuki Fujimoto Yuki Tsuji Masahide Enomoto Soichi Takeda Koji Murata Takahiro Kubo Satoshi Iwai Aritoshi Koizumi Akihiko Shibamoto Junya Suzuki Misako Tanaka Takuya Matsuda Nobuyuki Yorioka Hiroyuki Masuda Masayoshi Takami Hitoshi Yoshiji |
| author_sort | Koh Kitagawa |
| collection | DOAJ |
| description | Abstract Objectives Serial pancreatic juice aspiration cytological examination (SPACE) via endoscopic retrograde cholangiopancreatography is a useful diagnostic method for early‐stage pancreatic cancer, such as carcinoma in situ that are difficult to diagnose by endoscopic ultrasound‐guided fine needle aspiration (EUS‐FNA). However, the diagnostic accuracy of SPACE is low, which is attributed to problems regarding specimen treatment. Hence, we evaluated the diagnostic efficacy of liquid‐based cytology (LBC) in pancreatic juice cytology for pancreatic cancer. Methods We retrospectively analyzed 24 patients with suspected pancreatic cancer that was difficult to diagnose by endoscopic ultrasound‐guided fine needle aspiration who underwent SPACE using LBC between April 2017 and April 2021. Results The most common reason for performing SPACE was localized stenosis of the main pancreatic duct without a mass. Eleven patients were diagnosed with malignancy after surgical resection, nine of whom had pancreatic ductal adenocarcinoma. Ten patients were diagnosed as benign after a follow‐up of more than 1 year. The nine cases of malignancy were diagnosed before surgical resection by SPACE using LBC, with a sensitivity of 81.8% and specificity of 100%. The overall diagnostic accuracy was 91.7%. A total of 152 LBC examinations were performed via SPACE, with an adequate sample collection rate of 88.9%. No adverse events, including acute pancreatitis, occurred after endoscopic retrograde cholangiopancreatography. Conclusion SPACE with LBC offers good diagnostic efficacy in patients with pancreatic cancer that is difficult to diagnose by endoscopic ultrasound‐guided fine needle aspiration. |
| first_indexed | 2024-04-09T15:22:52Z |
| format | Article |
| id | doaj.art-ad0962f8fbc64989bf3add951f27d134 |
| institution | Directory Open Access Journal |
| issn | 2692-4609 |
| language | English |
| last_indexed | 2024-04-09T15:22:52Z |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | DEN Open |
| spelling | doaj.art-ad0962f8fbc64989bf3add951f27d1342023-04-29T05:12:58ZengWileyDEN Open2692-46092023-04-0131n/an/a10.1002/deo2.177Diagnostic yield of liquid‐based cytology in serial pancreatic juice aspiration cytological examinationKoh Kitagawa0Akira Mitoro1Fumimasa Tomooka2Shohei Asada3Yukihisa Fujinaga4Norihisa Nishimura5Kosuke Kaji6Hideto Kawaratani7Takemi Akahane8Takahiro Ozutsumi9Miki Kaneko10Yuki Fujimoto11Yuki Tsuji12Masahide Enomoto13Soichi Takeda14Koji Murata15Takahiro Kubo16Satoshi Iwai17Aritoshi Koizumi18Akihiko Shibamoto19Junya Suzuki20Misako Tanaka21Takuya Matsuda22Nobuyuki Yorioka23Hiroyuki Masuda24Masayoshi Takami25Hitoshi Yoshiji26Department of Gastroenterology Nara Medical University Nara JapanDivision of Endoscopy Nara Medical University Nara JapanDepartment of Gastroenterology Nara Medical University Nara JapanDepartment of Gastroenterology Nara Medical University Nara JapanDepartment of Gastroenterology Nara Medical University Nara JapanDepartment of Gastroenterology Nara Medical University Nara JapanDepartment of Gastroenterology Nara Medical University Nara JapanDepartment of Gastroenterology Nara Medical University Nara JapanDepartment of Gastroenterology Nara Medical University Nara JapanDepartment of Gastroenterology Nara Medical University Nara JapanDepartment of Gastroenterology Nara Medical University Nara JapanDepartment of Gastroenterology Nara Medical University Nara JapanDepartment of Gastroenterology Nara Medical University Nara JapanDepartment of Gastroenterology Nara Medical University Nara JapanDepartment of Gastroenterology Nara Medical University Nara JapanDepartment of Gastroenterology Nara Medical University Nara JapanDepartment of Gastroenterology Nara Medical University Nara JapanDepartment of Gastroenterology Nara Medical University Nara JapanDepartment of Gastroenterology Nara Medical University Nara JapanDepartment of Gastroenterology Nara Medical University Nara JapanDepartment of Gastroenterology Nara Medical University Nara JapanDepartment of Gastroenterology Nara Medical University Nara JapanDepartment of Gastroenterology Nara Medical University Nara JapanDepartment of Gastroenterology Nara Medical University Nara JapanDepartment of Gastroenterology Nara Medical University Nara JapanDepartment of Gastroenterology Nara Medical University Nara JapanDepartment of Gastroenterology Nara Medical University Nara JapanAbstract Objectives Serial pancreatic juice aspiration cytological examination (SPACE) via endoscopic retrograde cholangiopancreatography is a useful diagnostic method for early‐stage pancreatic cancer, such as carcinoma in situ that are difficult to diagnose by endoscopic ultrasound‐guided fine needle aspiration (EUS‐FNA). However, the diagnostic accuracy of SPACE is low, which is attributed to problems regarding specimen treatment. Hence, we evaluated the diagnostic efficacy of liquid‐based cytology (LBC) in pancreatic juice cytology for pancreatic cancer. Methods We retrospectively analyzed 24 patients with suspected pancreatic cancer that was difficult to diagnose by endoscopic ultrasound‐guided fine needle aspiration who underwent SPACE using LBC between April 2017 and April 2021. Results The most common reason for performing SPACE was localized stenosis of the main pancreatic duct without a mass. Eleven patients were diagnosed with malignancy after surgical resection, nine of whom had pancreatic ductal adenocarcinoma. Ten patients were diagnosed as benign after a follow‐up of more than 1 year. The nine cases of malignancy were diagnosed before surgical resection by SPACE using LBC, with a sensitivity of 81.8% and specificity of 100%. The overall diagnostic accuracy was 91.7%. A total of 152 LBC examinations were performed via SPACE, with an adequate sample collection rate of 88.9%. No adverse events, including acute pancreatitis, occurred after endoscopic retrograde cholangiopancreatography. Conclusion SPACE with LBC offers good diagnostic efficacy in patients with pancreatic cancer that is difficult to diagnose by endoscopic ultrasound‐guided fine needle aspiration.https://doi.org/10.1002/deo2.177ENPDERCPpancreatic cancerpancreatic juice cytologyliquid‐based cytology |
| spellingShingle | Koh Kitagawa Akira Mitoro Fumimasa Tomooka Shohei Asada Yukihisa Fujinaga Norihisa Nishimura Kosuke Kaji Hideto Kawaratani Takemi Akahane Takahiro Ozutsumi Miki Kaneko Yuki Fujimoto Yuki Tsuji Masahide Enomoto Soichi Takeda Koji Murata Takahiro Kubo Satoshi Iwai Aritoshi Koizumi Akihiko Shibamoto Junya Suzuki Misako Tanaka Takuya Matsuda Nobuyuki Yorioka Hiroyuki Masuda Masayoshi Takami Hitoshi Yoshiji Diagnostic yield of liquid‐based cytology in serial pancreatic juice aspiration cytological examination DEN Open ENPD ERCP pancreatic cancer pancreatic juice cytology liquid‐based cytology |
| title | Diagnostic yield of liquid‐based cytology in serial pancreatic juice aspiration cytological examination |
| title_full | Diagnostic yield of liquid‐based cytology in serial pancreatic juice aspiration cytological examination |
| title_fullStr | Diagnostic yield of liquid‐based cytology in serial pancreatic juice aspiration cytological examination |
| title_full_unstemmed | Diagnostic yield of liquid‐based cytology in serial pancreatic juice aspiration cytological examination |
| title_short | Diagnostic yield of liquid‐based cytology in serial pancreatic juice aspiration cytological examination |
| title_sort | diagnostic yield of liquid based cytology in serial pancreatic juice aspiration cytological examination |
| topic | ENPD ERCP pancreatic cancer pancreatic juice cytology liquid‐based cytology |
| url | https://doi.org/10.1002/deo2.177 |
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