High SNAIL Expression Reflects Of Recurrence After Resection Colorectal Cancer Liver Metastasis
Introduction: Metastasectomy is one of the effective treatment methods for liver metastases developing from primary colorectal cancer (CRC). However, recurrence after metastasectomy is the biggest problem in these cancers. The present study aimed to examine the role of Epithelial-Mesenchymal Transi...
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| Format: | Article |
| Language: | English |
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Sakarya University
2022-12-01
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| Series: | Sakarya Tıp Dergisi |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/tr/download/article-file/2476831 |
| _version_ | 1797350490324860928 |
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| author | Fuat Aksoy Ömer Yerci Nesrin Uğraş Melis Erçelik Çağla Tekin Ahmet Karamustafaoğlu Berrin Tunca Secil Ak Aksoy Ekrem Kaya |
| author_facet | Fuat Aksoy Ömer Yerci Nesrin Uğraş Melis Erçelik Çağla Tekin Ahmet Karamustafaoğlu Berrin Tunca Secil Ak Aksoy Ekrem Kaya |
| author_sort | Fuat Aksoy |
| collection | DOAJ |
| description | Introduction: Metastasectomy is one of the effective treatment methods for liver metastases developing from primary colorectal cancer (CRC). However, recurrence after metastasectomy is the biggest problem in these cancers.
The present study aimed to examine the role of Epithelial-Mesenchymal Transition (EMT) in the development of recurrence after metastasectomy in liver metastases from primary CRCs.
Materials and Methods: In the study, 85 patients were evaluated. RNA was isolated from archive tumors and normal tissues of the patients. Expression profiles of 7 different EMT markers were examined using qRT-PCR.
Results: Metastasis to the liver developed in 24.7% (n=21) of 85 CRC. Recurrence was observed in 42.3% (n=9) of liver metastases after metastasectomy. Statistically significant increases were detected in the expression of EMT markers TWIST and SNAIL in the development of mCC in primary CRC (p |
| first_indexed | 2024-03-08T12:46:38Z |
| format | Article |
| id | doaj.art-ad0984c58ba94a148483337ec2f5b2aa |
| institution | Directory Open Access Journal |
| issn | 2146-409X |
| language | English |
| last_indexed | 2024-03-08T12:46:38Z |
| publishDate | 2022-12-01 |
| publisher | Sakarya University |
| record_format | Article |
| series | Sakarya Tıp Dergisi |
| spelling | doaj.art-ad0984c58ba94a148483337ec2f5b2aa2024-01-21T07:40:05ZengSakarya UniversitySakarya Tıp Dergisi2146-409X2022-12-0112467267910.31832/smj.112843428High SNAIL Expression Reflects Of Recurrence After Resection Colorectal Cancer Liver MetastasisFuat Aksoy0Ömer Yerci1Nesrin Uğraş2Melis Erçelik3Çağla Tekin4Ahmet Karamustafaoğlu5Berrin Tunca6Secil Ak Aksoy7Ekrem Kaya8BURSA ULUDAG UNIVERSITYBURSA ULUDAG UNIVERSITYBURSA ULUDAG UNIVERSITYBURSA ULUDAG UNIVERSITYBURSA ULUDAG UNIVERSITYBURSA ULUDAG UNIVERSITYBURSA ULUDAG UNIVERSITYBURSA ULUDAG UNIVERSITYBURSA ULUDAG UNIVERSITYIntroduction: Metastasectomy is one of the effective treatment methods for liver metastases developing from primary colorectal cancer (CRC). However, recurrence after metastasectomy is the biggest problem in these cancers. The present study aimed to examine the role of Epithelial-Mesenchymal Transition (EMT) in the development of recurrence after metastasectomy in liver metastases from primary CRCs. Materials and Methods: In the study, 85 patients were evaluated. RNA was isolated from archive tumors and normal tissues of the patients. Expression profiles of 7 different EMT markers were examined using qRT-PCR. Results: Metastasis to the liver developed in 24.7% (n=21) of 85 CRC. Recurrence was observed in 42.3% (n=9) of liver metastases after metastasectomy. Statistically significant increases were detected in the expression of EMT markers TWIST and SNAIL in the development of mCC in primary CRC (phttps://dergipark.org.tr/tr/download/article-file/2476831metastazektomimetastatik karaciğer kanserleriepitelyal-mezenkimal tranzisyonmetastasectomymetastatic liver cancersepithelial-mesenchymal transition |
| spellingShingle | Fuat Aksoy Ömer Yerci Nesrin Uğraş Melis Erçelik Çağla Tekin Ahmet Karamustafaoğlu Berrin Tunca Secil Ak Aksoy Ekrem Kaya High SNAIL Expression Reflects Of Recurrence After Resection Colorectal Cancer Liver Metastasis Sakarya Tıp Dergisi metastazektomi metastatik karaciğer kanserleri epitelyal-mezenkimal tranzisyon metastasectomy metastatic liver cancers epithelial-mesenchymal transition |
| title | High SNAIL Expression Reflects Of Recurrence After Resection Colorectal Cancer Liver Metastasis |
| title_full | High SNAIL Expression Reflects Of Recurrence After Resection Colorectal Cancer Liver Metastasis |
| title_fullStr | High SNAIL Expression Reflects Of Recurrence After Resection Colorectal Cancer Liver Metastasis |
| title_full_unstemmed | High SNAIL Expression Reflects Of Recurrence After Resection Colorectal Cancer Liver Metastasis |
| title_short | High SNAIL Expression Reflects Of Recurrence After Resection Colorectal Cancer Liver Metastasis |
| title_sort | high snail expression reflects of recurrence after resection colorectal cancer liver metastasis |
| topic | metastazektomi metastatik karaciğer kanserleri epitelyal-mezenkimal tranzisyon metastasectomy metastatic liver cancers epithelial-mesenchymal transition |
| url | https://dergipark.org.tr/tr/download/article-file/2476831 |
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