Antigenic Properties of N Protein of Hantavirus
Hantavirus causes two important rodent-borne viral zoonoses, hemorrhagic fever with renal syndrome (HFRS) in Eurasia and hantavirus pulmonary syndrome (HPS) in North and South America. Twenty-four species that represent sero- and genotypes have been registered within the genus Hantavirus by the Inte...
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| Format: | Article |
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MDPI AG
2014-08-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/6/8/3097 |
| _version_ | 1828192932806524928 |
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| author | Kumiko Yoshimatsu Jiro Arikawa |
| author_facet | Kumiko Yoshimatsu Jiro Arikawa |
| author_sort | Kumiko Yoshimatsu |
| collection | DOAJ |
| description | Hantavirus causes two important rodent-borne viral zoonoses, hemorrhagic fever with renal syndrome (HFRS) in Eurasia and hantavirus pulmonary syndrome (HPS) in North and South America. Twenty-four species that represent sero- and genotypes have been registered within the genus Hantavirus by the International Committee on Taxonomy of Viruses (ICTV). Among the viral proteins, nucleocapsid (N) protein possesses an immunodominant antigen. The antigenicitiy of N protein is conserved compared with that of envelope glycoproteins. Therefore, N protein has been used for serological diagnoses and seroepidemiological studies. An understanding of the antigenic properties of N protein is important for the interpretation of results from serological tests using N antigen. N protein consists of about 430 amino acids and possesses various epitopes. The N-terminal quarter of N protein bears linear and immunodominant epitopes. However, a serotype-specific and multimerization-dependent antigenic site was found in the C-terminal half of N protein. In this paper, the structure, function, and antigenicity of N protein are reviewed. |
| first_indexed | 2024-04-12T09:00:52Z |
| format | Article |
| id | doaj.art-ad09924cd52248fbb12e0d767bbc7b85 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-04-12T09:00:52Z |
| publishDate | 2014-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-ad09924cd52248fbb12e0d767bbc7b852022-12-22T03:39:14ZengMDPI AGViruses1999-49152014-08-01683097310910.3390/v6083097v6083097Antigenic Properties of N Protein of HantavirusKumiko Yoshimatsu0Jiro Arikawa1Department of Microbiology, Graduate School of Medicine, Hokkaido University, Kita-ku, Kita-15, Nishi-7, Sapporo 060-8638, JapanDepartment of Microbiology, Graduate School of Medicine, Hokkaido University, Kita-ku, Kita-15, Nishi-7, Sapporo 060-8638, JapanHantavirus causes two important rodent-borne viral zoonoses, hemorrhagic fever with renal syndrome (HFRS) in Eurasia and hantavirus pulmonary syndrome (HPS) in North and South America. Twenty-four species that represent sero- and genotypes have been registered within the genus Hantavirus by the International Committee on Taxonomy of Viruses (ICTV). Among the viral proteins, nucleocapsid (N) protein possesses an immunodominant antigen. The antigenicitiy of N protein is conserved compared with that of envelope glycoproteins. Therefore, N protein has been used for serological diagnoses and seroepidemiological studies. An understanding of the antigenic properties of N protein is important for the interpretation of results from serological tests using N antigen. N protein consists of about 430 amino acids and possesses various epitopes. The N-terminal quarter of N protein bears linear and immunodominant epitopes. However, a serotype-specific and multimerization-dependent antigenic site was found in the C-terminal half of N protein. In this paper, the structure, function, and antigenicity of N protein are reviewed.http://www.mdpi.com/1999-4915/6/8/3097nucleocapsidmonoclonal antibodyepitope |
| spellingShingle | Kumiko Yoshimatsu Jiro Arikawa Antigenic Properties of N Protein of Hantavirus Viruses nucleocapsid monoclonal antibody epitope |
| title | Antigenic Properties of N Protein of Hantavirus |
| title_full | Antigenic Properties of N Protein of Hantavirus |
| title_fullStr | Antigenic Properties of N Protein of Hantavirus |
| title_full_unstemmed | Antigenic Properties of N Protein of Hantavirus |
| title_short | Antigenic Properties of N Protein of Hantavirus |
| title_sort | antigenic properties of n protein of hantavirus |
| topic | nucleocapsid monoclonal antibody epitope |
| url | http://www.mdpi.com/1999-4915/6/8/3097 |
| work_keys_str_mv | AT kumikoyoshimatsu antigenicpropertiesofnproteinofhantavirus AT jiroarikawa antigenicpropertiesofnproteinofhantavirus |