Articular cartilage corefucosylation regulates tissue resilience in osteoarthritis

Articular cartilage corefucosylation regulates tissue resilience in osteoarthritis

This study aimed to investigate the glycan structural changes that occur before histological degeneration in osteoarthritis (OA) and to determine the mechanism by which these glycan conformational changes affect cartilage degeneration. An OA model was established in rabbits using mannosidase injecti...

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Bibliographic Details
Main Authors: Kentaro Homan, Tomohiro Onodera, Hisatoshi Hanamatsu, Jun-ichi Furukawa, Daisuke Momma, Masatake Matsuoka, Norimasa Iwasaki
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-03-01
Series:eLife
Subjects:
fut8
high-mannose type N-glycan
corefucosylation
articular cartilage
glycome
early osteoarthritis
Online Access:https://elifesciences.org/articles/92275

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